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公开(公告)号:US5817796A
公开(公告)日:1998-10-06
申请号:US435628
申请日:1995-05-05
IPC分类号: C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12Q1/68
CPC分类号: C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要: Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译: 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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公开(公告)号:US5646042A
公开(公告)日:1997-07-08
申请号:US373124
申请日:1995-01-13
IPC分类号: C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12N5/22 , C12N5/16 , C12N9/22 , C12Q1/68
CPC分类号: C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要: Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译: 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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公开(公告)号:US06194150B1
公开(公告)日:2001-02-27
申请号:US09038073
申请日:1998-03-11
申请人: Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
发明人: Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
IPC分类号: C07H2104
CPC分类号: C07H19/16 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12N9/6491 , C12N15/113 , C12N15/1138 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/3521
摘要: Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1, B7-2, B7-3 and/or CD40.
摘要翻译: 阻断编码B7-1,B7-2,B7-3和/或CD40的mRNA的合成和/或表达的核酸分子。
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公开(公告)号:US5877021A
公开(公告)日:1999-03-02
申请号:US585684
申请日:1996-01-12
申请人: Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
发明人: Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
IPC分类号: C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N9/64 , C12N15/113 , C12Q1/68 , C12N5/08 , C70H21/02
CPC分类号: C07H19/16 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/113 , C12N15/1138 , C12N9/6491 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/3521
摘要: Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1.
摘要翻译: 阻断编码B7-1的mRNA的合成和/或表达的核酸分子。
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公开(公告)号:US6103890A
公开(公告)日:2000-08-15
申请号:US998099
申请日:1997-12-24
CPC分类号: C12N15/1135 , C12N15/113 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要: Enzymatic nucleic acid molecules which cleave c-fos RNA.
摘要翻译: 酶切核酸分子切割c-fos RNA。
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公开(公告)号:US20050176018A1
公开(公告)日:2005-08-11
申请号:US10715285
申请日:2003-11-17
申请人: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
发明人: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC分类号: C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P5/30 , A61P35/00 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68
CPC分类号: C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要: This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要翻译: 本发明涉及具有特异性结构的新型化学修饰的核酸分子,其表现出对核酸酶的增加的抗性并增加与靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法,以及包含所述分子的组合物和细胞。
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7.Nucleic acid molecules with novel chemical compositions capable of modulating gene expression 有权
标题翻译: 具有能够调节基因表达的新化学成分的核酸分子公开(公告)号:US06673611B2
公开(公告)日:2004-01-06
申请号:US09866316
申请日:2001-05-25
申请人: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
发明人: James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC分类号: C12Q168
CPC分类号: C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要: This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要翻译: 本发明涉及具有特异性结构的新化学修饰的核酸分子,其表现出对核酸酶的增加的抗性和增加的对靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法,以及包含所述分子的组合物和细胞。
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公开(公告)号:US08716320B2
公开(公告)日:2014-05-06
申请号:US11880501
申请日:2007-07-23
申请人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun
发明人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun
IPC分类号: A61K31/426 , A61K31/427 , A61K31/17 , C07D277/38 , C07D277/48 , C07C275/04 , C07C275/26
CPC分类号: A61K31/426 , A61K31/17 , A61K31/427 , C07C275/04 , C07C275/26 , C07D277/38 , C07D277/48
摘要: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
摘要翻译: 本发明提供具有有用的抗菌活性的新型杂环脲化合物,包含一种或多种这些化合物的药物组合物,其制备方法及其使用方法。
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公开(公告)号:US20080207703A1
公开(公告)日:2008-08-28
申请号:US11880501
申请日:2007-07-23
申请人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun
发明人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun
IPC分类号: A61K31/433 , A61K31/426 , C07D285/08
CPC分类号: A61K31/426 , A61K31/17 , A61K31/427 , C07C275/04 , C07C275/26 , C07D277/38 , C07D277/48
摘要: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
摘要翻译: 本发明提供具有有用抗菌活性的新型杂环脲化合物,包含这些化合物中的一种或多种的药物组合物,其制备方法及其使用方法。
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10.
公开(公告)号:US08293919B2
公开(公告)日:2012-10-23
申请号:US12669597
申请日:2008-07-23
申请人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
发明人: Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
IPC分类号: C07D285/08 , C07D277/44 , C07D417/12 , A61K31/4406 , A61K31/4965 , A61K31/427 , A61K31/433 , A61K31/425
CPC分类号: C07D277/48 , C07D285/08 , C07D417/12
摘要: The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
摘要翻译: 本发明提供具有有用抗菌活性的新型砜和亚砜取代的杂环脲化合物。 提供这些化合物作为药物组合物和生产方法的用途。
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