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    Oligonucleotides for modulating the effects of cytomegalovirus infections
    1.
    发明授权
    Oligonucleotides for modulating the effects of cytomegalovirus infections 失效
    调节巨细胞病毒感染影响的寡核苷酸

    公开(公告)号：US5442049A

    公开(公告)日：1995-08-15

    申请号：US9263

    申请日：1993-01-25

    申请人： Kevin Anderson ,  Kenneth Draper ,  Brenda Baker

    发明人： Kevin Anderson ,  Kenneth Draper ,  Brenda Baker

    IPC分类号： A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  A61K48/00

    CPC分类号： A61K31/711 ,  C12N15/1133 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322

    摘要： Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides such as ISIS 2922 are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed.

    摘要翻译： 公开了用于调节巨细胞病毒（CMV）感染的作用的组合物和方法，包括使CMV mRNA与可以与CMV RNA的至少一部分结合的寡核苷酸接触。 根据优选的实施方案，设计诸如ISIS 2922的寡核苷酸与编码IE1，IE2或DNA聚合酶蛋白的部分CMV mRNA结合。 根据优选实施方案，公开了治疗人巨细胞病毒的方法。