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    Genes encoding proteins with pesticidal activity
    8.
    发明申请
    Genes encoding proteins with pesticidal activity 有权
    编码具有杀虫活性的蛋白质的基因

    公开(公告)号：US20050261188A1

    公开(公告)日：2005-11-24

    申请号：US11108389

    申请日：2005-04-18

    申请人： Andre Abad ,  Ronald Flannagan ,  Rafael Herrmann ,  Theodore Kahn ,  Albert Lu ,  Billy McCutchen ,  James Presnail ,  James Wong ,  Cao-Guo Yu

    发明人： Andre Abad ,  Ronald Flannagan ,  Rafael Herrmann ,  Theodore Kahn ,  Albert Lu ,  Billy McCutchen ,  James Presnail ,  James Wong ,  Cao-Guo Yu

    IPC分类号： C07K14/325 ,  C12N15/32 ,  C12N15/82 ,  G06F19/00 ,  A01N63/00

    CPC分类号： C07K14/325 ,  C12N15/8286 ,  Y02A40/162

    摘要： The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding δ-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.

    摘要翻译： 本发明提供从编码具有杀虫活性的昆虫害虫的δ-内毒素的苏云金芽孢杆菌菌株获得的核酸及其变体和片段。 本发明进一步提供已被修饰以编码杀虫多肽的诱变核酸，例如具有改善的杀虫活性和/或改变的有害生物特异性的内毒素。 本发明的具体实施方案提供编码可能被优化的杀虫蛋白质的分离的核酸，以及包含本发明的核酸的农药组合物，表达盒和转化的微生物和植物。 这些组合物可用于防治害虫，特别是植物害虫的方法。

    Plant activation of insect toxin
    9.
    发明申请
    Plant activation of insect toxin 有权
    植物激活昆虫毒素

    公开(公告)号：US20050166284A1

    公开(公告)日：2005-07-28

    申请号：US11021115

    申请日：2004-12-22

    申请人： Andre Abad ,  Ronald Flannagan ,  Rafael Herrmann ,  Albert Lu ,  Billy McCutchen ,  James Presnail ,  Janet Rice ,  James Wong ,  Cao-Guo Yu

    发明人： Andre Abad ,  Ronald Flannagan ,  Rafael Herrmann ,  Albert Lu ,  Billy McCutchen ,  James Presnail ,  Janet Rice ,  James Wong ,  Cao-Guo Yu

    IPC分类号： A01H1/00 ,  A01H5/00 ,  C07K14/325 ,  C12N9/64 ,  C12N15/82

    CPC分类号： C12N15/8286 ,  C12N9/641 ,  Y02A40/162

    摘要： Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.

    摘要翻译： 提供了保护植物免受害虫害虫的组合物和方法。 特别地，提供了编码昆虫原毒素的核酸序列，其被修饰为包含对植物蛋白酶或昆虫肠道蛋白酶敏感的至少一个蛋白水解活化位点。 通过蛋白酶在蛋白水解活化位点切割修饰的原毒素会产生活性昆虫毒素。 提供了使用修饰的昆虫原毒素核酸序列及其编码的多肽保护植物免受害虫的方法。 本发明的具体实施方案还提供了改良的昆虫原毒素组合物和制剂，表达盒，以及转化的植物，植物细胞和种子。

    Antifungal polypeptides
    10.
    发明申请
    Antifungal polypeptides 有权
    抗真菌多肽

    公开(公告)号：US20060031962A1

    公开(公告)日：2006-02-09

    申请号：US11174413

    申请日：2005-07-01

    申请人： Daniel Altier ,  Glen Dahlbacka ,  I.A. Ellanskaya ,  Rafael Herrmann ,  Jennie Hunter-Cevera ,  Billy McCutchen ,  James Presnail ,  Janet Rice ,  Eric Schepers ,  Carl Simmons ,  Tamas Torok ,  Nasser Yalpani

    发明人： Daniel Altier ,  Glen Dahlbacka ,  I.A. Ellanskaya ,  Rafael Herrmann ,  Jennie Hunter-Cevera ,  Billy McCutchen ,  James Presnail ,  Janet Rice ,  Eric Schepers ,  Carl Simmons ,  Tamas Torok ,  Nasser Yalpani

    IPC分类号： A61K38/17 ,  A01H1/00 ,  C07H21/04 ,  C12N5/04 ,  C07K14/415 ,  C12N15/82

    CPC分类号： C07K14/37 ,  A01N63/02 ,  A01N63/04 ,  A61K38/00 ,  C07K14/385 ,  C12N15/8282

    摘要： Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

    摘要翻译： 提供了用于保护植物免受病原体，特别是真菌病原体的组合物和方法。 组合物包括从微生物发酵液中分离的抗病原体多肽的新型氨基酸序列及其变体和片段。 还提供了包含编码本发明的抗病原多肽的核苷酸序列的核酸分子。 还提供使用本文公开的核苷酸序列在植物中诱导病原体抗性的方法。 该方法包括向植物中引入包含可操作地连接到编码本发明的抗病原体多肽的核苷酸序列的启动子的表达盒。 还提供包含抗病原体多肽或包含本发明的核酸与载体组合的转化微生物的组合物，以及使用这些组合物保护植物免受病原体的方法。 还公开了包含编码本发明的抗病原体多肽的核苷酸序列或其变体或片段的转化植物，植物细胞，种子和微生物。