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公开(公告)号：US11291670B2
公开(公告)日：2022-04-05
申请号：US12915709
申请日：2010-10-29
IPC分类号： A61K31/55 , A61K31/42 , A61K31/37 , A61K31/4365 , A61K45/06 , A61K31/155 , A61K31/195 , A61K31/64
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.
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公开(公告)号：US09820978B2
公开(公告)日：2017-11-21
申请号：US14002429
申请日：2012-03-01
IPC分类号： A61K31/197 , A61K31/185 , A61K31/64 , A61K31/138 , A61K31/137 , A61K31/42 , A61P9/10 , A61K31/44 , A61K31/195 , A61K31/445 , A61K45/06 , A61K31/145 , A61K31/164 , A61K31/428
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia.
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公开(公告)号：US20120108528A1
公开(公告)日：2012-05-03
申请号：US13260773
申请日：2010-03-29
申请人： Daniel Cohen , Serguei Nabirochkin , Ilya Chumakov
发明人： Daniel Cohen , Serguei Nabirochkin , Ilya Chumakov
IPC分类号： A61K31/7028 , A61K31/4709 , A61P37/00 , A61P25/00 , A61P29/00 , A61K31/4365 , A61K31/4465
CPC分类号： A61K31/137 , A61K31/4365 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel compositions which can be used for the treatment of neuroinflammation, in particular in subjects having a neurodegenerative, autoimmune, infectious, toxic or traumatic disorder. More particularly, the invention relates to combined therapies for treating neuroinflammation. The invention also discloses new methods for treating neuroinflammation pathological conditions in a subject.
摘要翻译： 本发明涉及可用于治疗神经炎症的新型组合物，特别涉及具有神经退行性，自身免疫性，感染性，毒性或创伤性疾病的受试者。 更具体地，本发明涉及用于治疗神经炎症的组合疗法。 本发明还公开了治疗受试者神经炎症病理状况的新方法。
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4.发明申请COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS 有权吡喹酮和甲巯咪唑联合治疗嗜酸性粒细胞病和相关疾病公开(公告)号：US20120040940A1
公开(公告)日：2012-02-16
申请号：US12999125
申请日：2009-06-17
IPC分类号： A61K31/56 , A61K31/4164 , A61P25/00 , A61K31/4178
CPC分类号： A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/485 , A61K31/575 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth病和相关周围神经病的组合物和方法。 更具体地，本发明涉及通过同时影响受试者中毒蕈碱受体信号传导和甲状腺激素途径来治疗所述疾病的组合疗法。
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公开(公告)号：US09493834B2
公开(公告)日：2016-11-15
申请号：US13387174
申请日：2010-07-29
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2800/2821 , G01N2800/60
摘要： The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatments, including validation of biomarkers for clinical trials.
摘要翻译： 本发明涉及用于诊断阿尔茨海默病（AD）的新型生物标志物的发展，验证和应用以及相关疾病，包括MCI的早期诊断和AD的早期前驱症，疾病亚型的鉴定，对疾病管理的反应的预测 程序，药物及其组合，并监测这些治疗的反应，包括验证临床试验的生物标志物。
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公开(公告)号：US08992891B2
公开(公告)日：2015-03-31
申请号：US12744962
申请日：2008-11-28
IPC分类号： A61K31/197 , A61K31/4164 , A61K39/395 , A61K31/485 , A61K9/127 , A61K9/00 , A61K9/08 , A61K9/48 , A61K31/7004
CPC分类号： A61K31/485 , A61K9/0095 , A61K9/08 , A61K9/4866 , A61K31/047 , A61K31/197 , A61K31/7004
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth疾病和相关疾病的组合物和方法。 更具体地，本发明涉及通过影响受试者中的PMP22表达来治疗所述疾病的组合疗法。
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7.发明授权Combination of pilocarpin and methimazol for treating Charcot-Marietooth disease and related disorders 有权组合毛果芸香碱和甲巯咪唑治疗Charcot-Marietooth疾病及相关疾病公开(公告)号：US08716269B2
公开(公告)日：2014-05-06
申请号：US12999125
申请日：2009-06-17
IPC分类号： A61K31/56 , A61K31/4164 , A61P25/00 , A61K31/4178
CPC分类号： A61K31/047 , A61K31/192 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/485 , A61K31/575 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth病和相关周围神经病的组合物和方法。 更具体地，本发明涉及通过同时影响受试者中毒蕈碱受体信号传导和甲状腺激素途径来治疗所述疾病的组合疗法。
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公开(公告)号：US20120088744A1
公开(公告)日：2012-04-12
申请号：US13375288
申请日：2010-05-28
申请人： Daniel Cohen , Serguei Nabirochkin , Ilya Chumakov
发明人： Daniel Cohen , Serguei Nabirochkin , Ilya Chumakov
IPC分类号： A61K31/567 , A61K31/439 , A61K31/436 , A61K31/4164 , A61P25/00 , A61P21/00 , A61K31/4178 , A61K31/192 , B82Y5/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K31/047 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/4164 , A61K31/4178 , A61K31/436 , A61K31/439 , A61K31/555 , A61K31/567 , A61K31/575 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.
摘要翻译： 本发明涉及治疗Charcot-Marie-Tooth疾病和相关疾病的组合物和方法。
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公开(公告)号：US20140080873A1
公开(公告)日：2014-03-20
申请号：US14002429
申请日：2012-03-01
IPC分类号： A61K31/197 , A61K31/137 , A61K31/145 , A61K31/42 , A61K31/164 , A61K31/44 , A61K31/138
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia.
摘要翻译： 本发明涉及用于保护神经细胞免受缺血或缺氧事件的新组合物和方法。 更准确地说，本发明提供了有效保护神经细胞免受缺血或缺氧的新的组合疗法。
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10.发明授权Therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response 有权通过调节细胞应激反应治疗阿尔茨海默病和相关疾病的治疗方法公开(公告)号：US08552041B2
公开(公告)日：2013-10-08
申请号：US12915689
申请日：2010-10-29
IPC分类号： A61K31/137 , A61K31/42 , A61P25/28
CPC分类号： A61K45/06 , A61K31/137 , A61K31/155 , A61K31/167 , A61K31/185 , A61K31/343 , A61K31/423 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease.
摘要翻译： 本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。 更具体地，本发明涉及调节细胞应激反应以治疗所述疾病的组合疗法。
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