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公开(公告)号：US10357130B2
公开(公告)日：2019-07-23
申请号：US15442751
申请日：2017-02-27
摘要： The problem of evenly cooking a food item so that all sides cook and brown evenly is solved by the use of a roasting platform that raises above rendered substances that can cause a steam and wetness to the surface of a food item. The roasting platform can be foldable or compressed, so that it takes up minimal storage space and can be deployed for use. Drain holes allow rendered substances to be more quickly separated from the surface of a food item. The same drain holes can be used as visual indicators when deploying the roasting platform to show when he folds of a roasting platform are sufficiently separated for maximum usable area and support for a weight placed thereon.
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公开(公告)号：US20180242782A1
公开(公告)日：2018-08-30
申请号：US15442751
申请日：2017-02-27
CPC分类号： A47J37/049 , A47J36/02 , A47J37/067 , A47J37/0694
摘要： The problem of evenly cooking a food item so that all sides cook and brown evenly is solved by the use of a roasting platform that raises above rendered substances that can cause a steam and wetness to the surface of a food item. The roasting platform can be foldable or compressed, so that it takes up minimal storage space and can be deployed for use. Drain holes allow rendered substances to be more quickly separated from the surface of a food item. The same drain holes can be used as visual indicators when deploying the roasting platform to show when he folds of a roasting platform are sufficiently separated for maximum usable area and support for a weight placed thereon.
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公开(公告)号：US20180230178A1
公开(公告)日：2018-08-16
申请号：US15752144
申请日：2016-08-11
申请人： Michael D. ALTMAN , Brian ANDRESEN , Wonsuk CHANG , Matthew Lloyd CHILDERS , Jared N. CUMMING , Andrew Marc HAIDLE , Timothy J. HENDERSON , James P. JEWELL , Min LU , Alan B. NORTHRUP , Ryan D. OTTE , Tony SIU , Benjamin Wesley TROTTER , Quang T TRUONG , Merck Sharp & Dohme Corp.
发明人： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong
摘要： A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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公开(公告)号：US09073929B2
公开(公告)日：2015-07-07
申请号：US14112945
申请日：2012-04-20
申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/41 , A61K45/06
CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合成酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。
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公开(公告)号：US20140045819A1
公开(公告)日：2014-02-13
申请号：US14112945
申请日：2012-04-20
申请人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
发明人： Scott B. Hoyt , Whitney Lane Petrilli , Clare London , Yusheng Xiong , Jerry Andrew Taylor , Amjad Ali , Michael Man-Chu Lo , Timothy J. Henderson , Qingzhong Hu , Rolf Hartmann , Lina Yin , Ralf Heim , Emmanuel Bey , Rohit Saxena , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/41 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合成酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。
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公开(公告)号：US20160214997A1
公开(公告)日：2016-07-28
申请号：US14914843
申请日：2014-08-25
申请人： Amjad ALI , Gioconda V. GALLO , Timothy J. HENDERSON , Rongze KUANG , Yeon-Hee LIM , Michael Man-Chu LO , Edward METZGER , Manuel de Lera RUIZ , Andrew STAMFORD , Paul TEMPEST , Brent WHITEHEAD , Heping WU , MERCK SHARP & DOHME CORP.
发明人： Ali Amjad , Gioconda V. Gallo , Timothy J. Henderson , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Edward Metzger , Manuel de Lera Ruiz , Andrew Stamford , Paul Tempest , Brent Whitehead , Heping Wu
IPC分类号： C07D519/00 , C07D491/147
CPC分类号： C07D519/00 , C07D491/147
摘要： The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
摘要翻译： 本发明涉及作为A2A受体拮抗剂的2,2-二氟二氧代己基化合物。 本发明还涉及本文所述的2,2-二氟二氧代环戊基化合物在涉及A2A受体的神经障碍和疾病的潜在治疗或预防中的用途。 本发明还涉及包含这些化合物的药物组合物以及这些药物组合物用于预防或治疗其中涉及A2A受体的疾病的用途。
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公开(公告)号：US11046714B2
公开(公告)日：2021-06-29
申请号：US14914843
申请日：2014-08-25
申请人： Merck Sharp & Dohme Corp. , Ali Amjad , Gioconda V. Gallo , Timothy J. Henderson , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Edward Metzger , Manuel de Lera Ruiz , Andrew Stamford , Paul Tempest , Brent Whitehead , Heping Wu
发明人： Ali Amjad , Gioconda V. Gallo , Timothy J. Henderson , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Edward Metzger , Manuel de Lera Ruiz , Andrew Stamford , Paul Tempest , Brent Whitehead , Heping Wu
IPC分类号： C07D519/00 , C07D491/147
摘要： The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
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公开(公告)号：US10738074B2
公开(公告)日：2020-08-11
申请号：US15752144
申请日：2016-08-11
申请人： Merck Sharp & Dohme Corp. , Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong
发明人： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong
IPC分类号： A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , A61K39/39 , C07H19/20 , C07H19/23 , C07H21/00 , A61P35/00 , A61K31/7064 , A61K31/7084 , A61K31/708 , A61K31/706 , A61K31/7076
摘要： A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
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公开(公告)号：US20120232039A1
公开(公告)日：2012-09-13
申请号：US13412032
申请日：2012-03-05
申请人： Amjad ALI , Michael Man-Chu Lo , Brent Whitehead , Shrenik K. Shah , Lin Yan , Timothy J. Henderson , Zack Zhiqiang Guo
发明人： Amjad ALI , Michael Man-Chu Lo , Brent Whitehead , Shrenik K. Shah , Lin Yan , Timothy J. Henderson , Zack Zhiqiang Guo
IPC分类号： A61K31/655 , A61P9/12 , C07C245/24
CPC分类号： C07D211/46 , C07D207/12 , C07D207/273 , C07D207/48 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12
摘要： A compound having the structure useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译： 具有用于治疗高血压，肺动脉高压（PAH），充血性心力衰竭，由过度保水引起的病症，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病的结构的化合物。
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公开(公告)号：US20240079150A1
公开(公告)日：2024-03-07
申请号：US18388155
申请日：2023-11-08
摘要： The invention includes remote-participation of a medical device manufacturing company representative in a medical procedure, whereby the device representative uses a variety of components including a surgical grid with multiple indicators for medical objects to track and monitor devices in an operating room in “real-time,” while checking on device status and advising a surgeon through Wearable Video Technology rather than being physically present in the operating room.
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