专利检索 ap:("Merck Sharp & Dohme Corp." OR "Michael D. Altman" OR "Brian Andresen" OR "Wonsuk Chang" OR "Matthew Lloyd Childers" OR "Jared N. Cumming" OR "Andrew Marc Haidle" OR "Timothy J. Henderson" OR "James P. Jewell" OR "Min Lu" OR "Alan B. Northrup" OR "Ryan D. Otte" OR "Tony Siu" OR "Benjamin Wesley Trotter" OR "Quang T. Truong") AND inv:"Ryan D. Otte" 第 1 页

1.

发明申请
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS 审中-公开

公开(公告)号：US20180230178A1

公开(公告)日：2018-08-16

申请号：US15752144

申请日：2016-08-11

申请人： Michael D. ALTMAN , Brian ANDRESEN , Wonsuk CHANG , Matthew Lloyd CHILDERS , Jared N. CUMMING , Andrew Marc HAIDLE , Timothy J. HENDERSON , James P. JEWELL , Min LU , Alan B. NORTHRUP , Ryan D. OTTE , Tony SIU , Benjamin Wesley TROTTER , Quang T TRUONG , Merck Sharp & Dohme Corp.

发明人： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong

IPC分类号： C07H21/04 , C07H21/02 , C07H19/23 , C07H19/20 , A61P35/00

摘要： A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

2.

发明授权
Cyclic di-nucleotide compounds as STING agonists 有权

公开(公告)号：US10738074B2

公开(公告)日：2020-08-11

申请号：US15752144

申请日：2016-08-11

申请人： Merck Sharp & Dohme Corp. , Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong

发明人： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong

IPC分类号： A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , A61K39/39 , C07H19/20 , C07H19/23 , C07H21/00 , A61P35/00 , A61K31/7064 , A61K31/7084 , A61K31/708 , A61K31/706 , A61K31/7076

摘要： A class of polycyclic compounds of general formula (II), of general formula (II′), or of general formula (II″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

3.

发明申请
AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS 有权

公开(公告)号：US20210009608A1

公开(公告)日：2021-01-14

申请号：US17040192

申请日：2019-03-28

申请人： Michael D. ALTMAN , Brandon D. CASH , Jared N. CUMMING , Duane E. DEMONG , Andrew M. HAIDLE , James P. JEWELL , Matthew A. LARSEN , Min LU , Ryan D. OTTE , Brandon M. TAOKA , Benjamin Wesley TROTTER , Quang T, TRUONG , Merck Sharp & Dohme Corp.

发明人： Michael D. Altman , Brandon D. Cash , Jared N. Cumming , Duane E. DeMong , Andrew M. Haidle , James P. Jewell , Matthew A. Larsen , Min Lu , Ryan D. Otte , Brandon M. Taoka , Benjamin Wesley Trotter , Quang T. Truong

IPC分类号： C07D513/04 , C07D495/04 , A61P37/04

摘要： Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R5, R6, R8, R9, A, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

4.

发明授权
Aza-benzothiophene compounds as STING agonists 有权

公开(公告)号：US11702430B2

公开(公告)日：2023-07-18

申请号：US17040192

申请日：2019-03-28

申请人： Merck Sharp & Dohme LLC , Michael D. Altman , Brandon D. Cash , Jared N. Cumming , Duane E. DeMong , Andrew M. Haidle , James P. Jewell , Matthew A. Larsen , Min Lu , Ryan D. Otte , Brandon M. Taoka , Benjamin Wesley Trotter , Quang T. Truong

发明人： Michael D. Altman , Brandon D. Cash , Jared N. Cumming , Duane E. DeMong , Andrew M. Haidle , James P. Jewell , Matthew A. Larsen , Min Lu , Ryan D. Otte , Brandon M. Taoka , Benjamin Wesley Trotter , Quang T. Truong

IPC分类号： C07D513/04 , C07D495/04 , C07D277/64 , A61P37/04 , A61P35/00

CPC分类号： C07D513/04 , A61P37/04 , C07D495/04

摘要： Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R5, R6, R8, R9, A, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

5.

发明申请
PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS 审中-公开
标题翻译： PRODRUG BIPYRIDYLAMINOPYRIDINES作为SYK抑制剂

公开(公告)号：US20150299125A1

公开(公告)日：2015-10-22

申请号：US14440517

申请日：2013-11-04

申请人： Andrew M. HAIDLE , Brandon CASH , James P. JEWELL , Kerrie SPENCER , Michael D. ALTMAN , Ryan D. OTTE , Alan B. NORTHRUP , MERCK SHARP & DOHME CORP.

发明人： Andrew M. Haidle , Brandon Cash , James P. Jewell , Kerrie Spencer , Michael D. Altman , Ryan D. Otte , Alan B. Northrup

IPC分类号： C07D213/74 , C07D401/14 , C07D405/14

CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D451/10 , C07H13/08

摘要： The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3′-bipyridin-6′-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

摘要翻译： 本发明提供式（I）化合物，其为反式-4 - [（1R） - （6 - {[4-（二氟甲基）吡啶-2-基]氨基} -4-甲基-2,3 “ - 联吡啶-6'-基）-1-羟乙基]环己烷羧酸，Syk的有效抑制剂。该化合物可用于治疗和预防由酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。

6.

发明申请
2-PYRAZINE CARBOXAMIDES AS SPLEEN TYROSINE KINASE INHIBITORS 有权
标题翻译： 2-吡咯烷酮类化合物作为稀释型酪氨酸激酶抑制剂

公开(公告)号：US20170071935A1

公开(公告)日：2017-03-16

申请号：US15125373

申请日：2015-03-09

申请人： Michael D. ALTMAN , Brandon CASH , John Michael ELLIS , Matthew L. MADDESS , Alan B. NORTHRUP , Ryan D. OTTE , Binyuan SUN , Merck Sharp & Dohme Corp.

发明人： Michael D. Altman , Brandon Cash , John Michael Ellis , Matthew L. Maddess , Alan B. Northrup , Ryan D. Otte , Binyuan Sun

IPC分类号： A61K31/497 , C07D405/04 , C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/056 , A61K45/06 , C07D409/14

CPC分类号： A61K31/497 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/056 , A61K2300/00

摘要： The invention provides certain pyrazine-2-carboxamide compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A, B, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

摘要翻译： 本发明提供了一些式（I）的吡嗪-2-甲酰胺化合物或其药学上可接受的盐，其中A，B和X如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。