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61 条记录 (耗时 0.039 秒)

    Diuretics
    3.
    发明授权
    Diuretics 有权
    利尿剂

    公开(公告)号：US08377911B2

    公开(公告)日：2013-02-19

    申请号：US13500509

    申请日：2010-09-20

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Lin Yan

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Lin Yan

    IPC分类号： A61K31/655 ,  C07D471/06

    CPC分类号： C07D491/04

    摘要： A compound having the structure formula (I) or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

    摘要翻译： 具有结构式（I）的化合物或其药学上可接受的盐，以及使用该化合物治疗高血压的方法。

    PROTEIN EXTRACTION METHODS
    5.
    发明申请
    PROTEIN EXTRACTION METHODS 有权
    蛋白提取方法

    公开(公告)号：US20120053328A1

    公开(公告)日：2012-03-01

    申请号：US13223737

    申请日：2011-09-01

    申请人： Lin Yan ,  Quanzhi Li

    发明人： Lin Yan ,  Quanzhi Li

    IPC分类号： C07K1/34 ,  C07K1/36 ,  C07K1/14

    CPC分类号： C07K1/34

    摘要： The present invention relates to methods for isolating polypepitdes from cells. The methods may be used to isolate denatured polypeptides or native polypeptides. In one embodiment the methods may be used to isolated polypeptide from cytosolic and nuclear compartments of eukaryotic cells. In one embodiment the methods may be used to isolate polypeptides from bacterial cells.

    摘要翻译： 本发明涉及从细胞中分离多肽的方法。 该方法可用于分离变性多肽或天然多肽。 在一个实施方案中，该方法可用于来自真核细胞的胞质和核隔室的分离的多肽。 在一个实施方案中，所述方法可用于从细菌细胞中分离多肽。

    Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
    6.
    发明授权
    Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators 失效
    取代的吡喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂

    公开(公告)号：US07999107B2

    公开(公告)日：2011-08-16

    申请号：US12009114

    申请日：2008-01-16

    申请人： John S. Debenham ,  Jeffrey J. Hale ,  Pei Huo ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh ,  Lin Yan

    发明人： John S. Debenham ,  Jeffrey J. Hale ,  Pei Huo ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh ,  Lin Yan

    IPC分类号： C07D491/052 ,  A61K31/436

    CPC分类号： C07D491/052 ,  C07D491/16 ,  C07D495/16

    摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.

    摘要翻译： 结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。 本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物 脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，亨廷顿病运动障碍和精神分裂症。 这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

    Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
    7.
    发明申请
    Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators 失效
    取代的吡喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂

    公开(公告)号：US20080207666A1

    公开(公告)日：2008-08-28

    申请号：US12009114

    申请日：2008-01-16

    申请人： John S. Debenham ,  Jeffrey J. Hale ,  Pei Huo ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh ,  Lin Yan

    发明人： John S. Debenham ,  Jeffrey J. Hale ,  Pei Huo ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh ,  Lin Yan

    IPC分类号： A61K31/527 ,  C07D471/10 ,  A61K31/4433 ,  C07D471/04 ,  A61P25/28

    CPC分类号： C07D491/052 ,  C07D491/16 ,  C07D495/16

    摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.

    摘要翻译： 结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。 本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物 脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，亨廷顿病运动障碍和精神分裂症。 这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

    Surfaces that resist the adsorption of biological species
    9.
    发明授权
    Surfaces that resist the adsorption of biological species 有权
    抵抗生物物种吸附的表面

    公开(公告)号：US07276286B2

    公开(公告)日：2007-10-02

    申请号：US09907551

    申请日：2001-07-17

    申请人： Robert G. Chapman ,  Emanuele Ostuni ,  Michael N. Liang ,  Lin Yan ,  George M. Whitesides

    发明人： Robert G. Chapman ,  Emanuele Ostuni ,  Michael N. Liang ,  Lin Yan ,  George M. Whitesides

    IPC分类号： B32B9/04 ,  B32B15/04 ,  B32B15/08 ,  B32B27/34

    CPC分类号： B82Y30/00 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  B82Y5/00 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/268 ,  Y10T428/269 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31725 ,  Y10T428/31855

    摘要： The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

    摘要翻译： 本发明提供了对蛋白质，细胞和细菌的吸附抗性的制品。 制品可以具有键合在其上的化学链，其中化学链可以包含不含氢键供体的末端基团或者氢键供体被充分掩埋，使得包含化学链的制品的暴露表面不含 氢键供体。 化学链或多个化学链可以包括单层，例如可以是均相（一种类型的SAM）或混合的，即或更多不同类型的SAM的自组装单层（SAM）。 提供了化学链的其他更具体的实例。 多个化学链可以包括诸如多胺的聚合物。 在许多方面，多个化学链足够地没有交联或分支。 本发明还提供能够特异性结合所需生物分子同时防止生物分子的非特异性结合的制品。