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公开(公告)号：US07763743B2
公开(公告)日：2010-07-27
申请号：US11592448
申请日：2006-11-03
IPC分类号： C07D317/00
摘要： This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
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公开(公告)号：US07994346B2
公开(公告)日：2011-08-09
申请号：US11592448
申请日：2006-11-03
IPC分类号： C07D317/00
CPC分类号： C07D317/72 , A61K31/202 , A61K31/216 , C07C59/68 , C07C59/70 , C07C69/708 , C07C69/736 , C07C209/68 , C07C217/46 , C07C229/12 , C07C235/06 , C07C323/52 , C07D317/22
摘要： This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
摘要翻译： 本发明涉及可用作合成下式（I）和（II）的脂氧素A4类似物的中间体的化合物：其中R1，R2，R3，R4和R5如本文所述。 这些类似物可用于治疗人类的炎性和自身免疫性疾病。 这些类似物也可用于治疗人类的肺或呼吸道炎症。
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公开(公告)号：US20070105949A1
公开(公告)日：2007-05-10
申请号：US11592448
申请日：2006-11-03
IPC分类号： A61K31/335 , C07D317/02
CPC分类号： C07D317/72 , A61K31/202 , A61K31/216 , C07C59/68 , C07C59/70 , C07C69/708 , C07C69/736 , C07C209/68 , C07C217/46 , C07C229/12 , C07C235/06 , C07C323/52 , C07D317/22
摘要： This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
摘要翻译： 本发明涉及可用作合成下式（I）和（II）的脂氧素A 4 H 4类似物的中间体的化合物：其中R 1，R 2， > 2，R 3，R 4和R 5在本文中描述。 这些类似物可用于治疗人类的炎性和自身免疫性疾病。 这些类似物也可用于治疗人类的肺或呼吸道炎症。
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公开(公告)号：US07737145B2
公开(公告)日：2010-06-15
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A01N43/60 , A61K31/495 , C07D241/36 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D513/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US20070155727A1
公开(公告)日：2007-07-05
申请号：US11644822
申请日：2006-12-22
申请人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
发明人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
IPC分类号： A61K31/551 , A61K31/407 , C07D487/02 , C07D243/08
CPC分类号： C07D207/04 , C07C237/04 , C07C237/06 , C07C237/30 , C07C255/58 , C07C275/40 , C07C275/42 , C07C275/62 , C07C311/05 , C07C311/08 , C07C311/09 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07D211/06 , C07D243/08 , C07D295/04 , C07D295/16 , C07D487/02 , C07D487/08
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4a，R 4， R 4b，R 4c，R 5a，R 5b，R 5c，R 5，R 5， R 6b，R 6b，R 6，R 7，R 8，R 8，R 8， 本文描述了本发明的其它药学上可接受的盐，溶剂合物，多晶型物，铵离子，N-氧化物或前体药物; 其是白三烯A 4水解酶抑制剂，因此其可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和使用和制备本发明化合物的方法。
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公开(公告)号：US08569303B2
公开(公告)日：2013-10-29
申请号：US12771659
申请日：2010-04-30
申请人： Damian O Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian O Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/495 , C07D241/36
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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7.发明授权5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection 失效5-氰基 - 前列环素衍生物作为治疗流感病毒感染的药剂公开(公告)号：US07776896B2
公开(公告)日：2010-08-17
申请号：US12079602
申请日：2008-03-27
申请人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Radüchel
发明人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Radüchel
IPC分类号： A61K31/41
CPC分类号： C07D307/937 , C07D405/06
摘要： This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中A，B，D，E，m和R 1 -R 5如本文所述，作为单一立体异构体或作为立体异构体或其药学上可接受的盐，包合物或前药的混合物 其可用于治疗与甲型流感病毒相关的呼吸道疾病，例如H5N1及其突变。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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8.发明申请Novel 5-cyano-prostacyclin derivatives as agents for the treatment of autoimmune diseases 审中-公开新型5-氰基 - 前列环素衍生物作为治疗自身免疫性疾病的药物公开(公告)号：US20080242713A1
公开(公告)日：2008-10-02
申请号：US12079598
申请日：2008-03-27
申请人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
发明人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
IPC分类号： A61K31/41 , A61K31/343 , C07D307/77 , A61P37/00 , C07D405/02
CPC分类号： C07D307/937 , C07D405/06
摘要： This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating autoimmune diseases. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中A，B，D，E，m和R 1 -R 5如本文所述，作为单 立体异构体或其立体异构体或其药学上可接受的盐，包合物或前药的混合物，其可用于治疗自身免疫性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US20070155726A1
公开(公告)日：2007-07-05
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
IPC分类号： A61K31/551 , A61K31/495 , A61K31/46 , A61K31/445 , A61K31/407
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4，R R 5，R 5b，R 5c，R 6a，R 6b，R 6b，R 6b，R 6b，R 6b， 本文描述了作为单一立体异构体或作为其中R 1，R 2，R 8和R 9的混合物 立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药; 其是白三烯A 4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US07928255B2
公开(公告)日：2011-04-19
申请号：US11585501
申请日：2006-10-23
IPC分类号： C07C57/00
CPC分类号： C07D317/72 , A61K31/202 , A61K31/216 , C07C59/68 , C07C59/70 , C07C69/708 , C07C69/736 , C07C209/68 , C07C217/46 , C07C229/12 , C07C235/06 , C07C323/52 , C07D317/22
摘要： This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
摘要翻译： 本发明涉及下述式（I）和（II）的脂氧素A4类似物：其中R1，R2，R3，R4和R5如本文所述。 这些类似物可用于治疗人类的炎性和自身免疫性疾病。 这些类似物也可用于治疗人类的肺或呼吸道炎症。
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