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公开(公告)号：US20080176833A1
公开(公告)日：2008-07-24
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： A61K31/55 , C07D213/02 , A61K31/4427 , C07D455/02 , A61K31/4375 , C07D295/00 , A61K31/5377 , A61P35/00 , C07D239/24 , A61K31/506 , C07D221/00 , A61K31/496 , C07D223/02
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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公开(公告)号：US6140351A
公开(公告)日：2000-10-31
申请号：US187459
申请日：1998-11-05
申请人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
发明人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
IPC分类号： C07D333/38 , C07D333/70 , C07D401/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34 , A61K31/44 , C07D409/00 , C07D411/00
CPC分类号： C07D401/04 , C07D333/38 , C07D333/70 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34
摘要： This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.
摘要翻译： 本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。 这些化合物被公开用作抗凝剂。
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公开(公告)号：US08198456B2
公开(公告)日：2012-06-12
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译： 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。
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4.发明申请Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents 审中-公开四氢萘衍生物，其制备方法及其作为抗炎剂的用途公开(公告)号：US20070129359A1
公开(公告)日：2007-06-07
申请号：US11414556
申请日：2006-05-01
申请人： Christoph Huwe , Werner Skuballa , Duy Nguyen , Heike Schaecke , Wheeseong Lee
发明人： Christoph Huwe , Werner Skuballa , Duy Nguyen , Heike Schaecke , Wheeseong Lee
IPC分类号： A61K31/538 , A61K31/498 , A61K31/4745 , A61K31/4704 , A61K31/404 , A61K31/4035
CPC分类号： C07C233/74 , C07C217/74 , C07C275/28 , C07C311/20 , C07C2602/10
摘要： The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (I) processes for their preparation and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式（I）的多取代四氢萘衍生物，其制备方法及其作为抗炎剂的用途。
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5.发明申请Novel 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection 失效新型5-氰基 - 前列环素衍生物作为治疗流感病毒感染的药剂公开(公告)号：US20080242714A1
公开(公告)日：2008-10-02
申请号：US12079602
申请日：2008-03-27
申请人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
发明人： William Guilford , Werner Skuballa , Daryl H. Faulds , Monica Kochanny , Wheeseong Lee , Bernd Raduchel
IPC分类号： A61K31/41 , C07D307/77 , A61K31/365 , A61P31/16 , C07D405/02
CPC分类号： C07D307/937 , C07D405/06
摘要： This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中A，B，D，E，m和R 1 -R 5如本文所述，作为单 立体异构体或其立体异构体或其药学上可接受的盐，包合物或前药的混合物，其可用于治疗与甲型流感病毒相关的呼吸系统疾病，例如H5N1及其突变。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US06380221B1
公开(公告)日：2002-04-30
申请号：US09631450
申请日：2000-08-03
申请人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
发明人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
IPC分类号： A61K3144
CPC分类号： C07D401/04 , C07D333/38 , C07D333/70 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34
摘要： This invention is directed to compounds of formula (III): wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These components are disclosed as being useful as anti-coagulants.
摘要翻译： 本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。 这些组分被公开用作抗凝剂。
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公开(公告)号：US07220856B2
公开(公告)日：2007-05-22
申请号：US10607530
申请日：2003-06-26
申请人： Laura Dunning , Stefan Jaroch , Monica J. Kochanny , Wheeseong Lee , Xiongdong Lian , Meina Liang , Shou-Fu Lu , James Onuffer , Gary Phillips , Guo-Ping Wei , Bin Ye
发明人： Laura Dunning , Stefan Jaroch , Monica J. Kochanny , Wheeseong Lee , Xiongdong Lian , Meina Liang , Shou-Fu Lu , James Onuffer , Gary Phillips , Guo-Ping Wei , Bin Ye
IPC分类号： C07D223/00 , C07D453/02
CPC分类号： C07D401/04 , C07D215/46 , C07D215/48 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/12 , C07D487/04 , C07D487/08 , C07D491/04
摘要： The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.
摘要翻译： 本发明涉及式（1a）或（1b）的CCR5受体拮抗剂：其对映异构体，非对映异构体，盐和溶剂化物，其中R 1，R 2，R 2 R 3，R 4，R 5和R 7如本文所定义。 本发明还包括使用这种化合物的CCR5介导的病症的方法。
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公开(公告)号：US20060167044A1
公开(公告)日：2006-07-27
申请号：US11305322
申请日：2005-12-19
申请人： Damian Arnaiz , Yuo-Ling Chou , Monica Kochanny , Wheeseong Lee , Shou-Fu Lu , Anne Mengel , Gary Phillips , Guo Wei , Hongyi Yu
发明人： Damian Arnaiz , Yuo-Ling Chou , Monica Kochanny , Wheeseong Lee , Shou-Fu Lu , Anne Mengel , Gary Phillips , Guo Wei , Hongyi Yu
IPC分类号： A61K31/4709 , A61K31/454 , C07D401/02 , C07D409/02
CPC分类号： C07D211/34 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/70 , C07D401/06 , C07D401/12 , C07D409/06 , C07D409/12 , C07D413/12
摘要： Piperidine derivatives of the following formulae I and II: and their pharmaceutically acceptable salts, which are functional antagonists of the CC chemokine receptor CCR1 and are thus useful as anti-inflammatory agents, a pharmaceutical compositions containing said piperidine derivatives or their pharmaceutically acceptable salts, and methods of their use.
摘要翻译： 下式I和II的哌啶衍生物及其药学上可接受的盐，其是CC趋化因子受体CCR1的功能性拮抗剂，因此可用作抗炎剂，含有所述哌啶衍生物或其药学上可接受的盐的药物组合物，以及 使用方法
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公开(公告)号：US20050101644A1
公开(公告)日：2005-05-12
申请号：US10984430
申请日：2004-11-08
申请人： David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
发明人： David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/135 , A61K31/165 , A61K31/40 , A61K31/435 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/44 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号： C07D207/16 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/14 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/64 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising such compounds, as well as the use of such compounds to treat CCR-5 mediated disorders.
摘要翻译： 本发明涉及通式I的CCR-5受体拮抗剂的化合物：其中R 1，R 2，R 3， R 4，R a，R b，R b，R c，R d， X，m和n如本文所定义。 本发明还包括含有这些化合物的药物组合物，以及这些化合物用于治疗CCR-5介导的病症的用途。
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10.发明申请Indolinone derivatives and their use in treating disease-states such as cancer 失效吲哚酮衍生物及其在治疗疾病状态如癌症中的应用公开(公告)号：US20050090541A1
公开(公告)日：2005-04-28
申请号：US10972023
申请日：2004-10-22
申请人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
发明人： Damian Arnaiz , Judi Bryant , Yuo-Ling Chou , Richard Feldman , Paul Hrvatin , Imadul Islam , Monica Kochanny , Wheeseong Lee , Mark Polokoff , Hongyi Yu , Shendong Yuan
IPC分类号： A61K31/405 , C07D209/34 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D407/14 , C07D409/06 , C07D413/14 , C07D43/02
CPC分类号： C07D209/34 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06
摘要： Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
摘要翻译： 吲哚啉酮衍生物，例如式（I）的化合物：其中A，m，n，R 1，R 2，R 3， 本文所述的本文所述的R 5和R 6 6可用于治疗通过抑制PDK-1活性而减轻疾病的哺乳动物。
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