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公开(公告)号：US20070155727A1
公开(公告)日：2007-07-05
申请号：US11644822
申请日：2006-12-22
申请人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
发明人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
IPC分类号： A61K31/551 , A61K31/407 , C07D487/02 , C07D243/08
CPC分类号： C07D207/04 , C07C237/04 , C07C237/06 , C07C237/30 , C07C255/58 , C07C275/40 , C07C275/42 , C07C275/62 , C07C311/05 , C07C311/08 , C07C311/09 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07D211/06 , C07D243/08 , C07D295/04 , C07D295/16 , C07D487/02 , C07D487/08
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4a，R 4， R 4b，R 4c，R 5a，R 5b，R 5c，R 5，R 5， R 6b，R 6b，R 6，R 7，R 8，R 8，R 8， 本文描述了本发明的其它药学上可接受的盐，溶剂合物，多晶型物，铵离子，N-氧化物或前体药物; 其是白三烯A 4水解酶抑制剂，因此其可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和使用和制备本发明化合物的方法。
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公开(公告)号：US20070155726A1
公开(公告)日：2007-07-05
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
IPC分类号： A61K31/551 , A61K31/495 , A61K31/46 , A61K31/445 , A61K31/407
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4，R R 5，R 5b，R 5c，R 6a，R 6b，R 6b，R 6b，R 6b，R 6b， 本文描述了作为单一立体异构体或作为其中R 1，R 2，R 8和R 9的混合物 立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药; 其是白三烯A 4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US20100210630A1
公开(公告)日：2010-08-19
申请号：US12771659
申请日：2010-04-30
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/551 , C07D487/08 , A61K31/504 , C07D243/08 , C07D263/32 , A61K31/421 , C07D211/58 , A61K31/4468 , C07D207/09 , A61K31/40 , C07D413/00 , A61K31/5377 , A61P29/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US07737145B2
公开(公告)日：2010-06-15
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A01N43/60 , A61K31/495 , C07D241/36 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D513/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US08569303B2
公开(公告)日：2013-10-29
申请号：US12771659
申请日：2010-04-30
申请人： Damian O Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian O Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/495 , C07D241/36
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译： 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US11793455B1
公开(公告)日：2023-10-24
申请号：US16601565
申请日：2019-10-14
申请人： Philippe Richard Kahn , Arthur Kinsolving , Mark Andrew Christensen , Mihai Ionescu , Sean Brooks Harre , David Vogel
发明人： Philippe Richard Kahn , Arthur Kinsolving , Mark Andrew Christensen , Mihai Ionescu , Sean Brooks Harre , David Vogel
CPC分类号： A61B5/4815 , A47C20/04 , A47C20/041 , A61B5/4809 , A61B5/4812 , A61G7/018 , A61B5/0205 , A61G7/05
摘要： A sleep sensor system comprising a sensor to collect movement data from a sleeper on an adjustable bed, a receiver to send movement data from the sensor to a server. The sleep sensor system further comprising the receiver to receive command data from the server, a bed controller to transmit bed movement command data to the adjustable bed, to cause the adjustable bed to alter one or more settings, and an IoT controller to transmit IoT command data to an IoT device to cause the IoT device to take an action.
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公开(公告)号：US10043388B1
公开(公告)日：2018-08-07
申请号：US14281849
申请日：2014-05-19
IPC分类号： G08G1/14
摘要： A method of managing a parking system comprising receiving a request for a parking location from a user of a mobile device, selecting an available spot, and guiding the user to the available spot. The method in on embodiment further comprises marking the parking location. In one embodiment, the user may also be given guidance back to the marked parking location.
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公开(公告)号：US09529437B2
公开(公告)日：2016-12-27
申请号：US12472361
申请日：2009-05-26
CPC分类号： G06F3/017 , H04M1/6058 , H04M2250/12
摘要： A device comprising a motion context logic that receives data from at least one motion sensor is described. The motion context logic determines a user's motion context. Context based action logic manages the device based on the user's motion context.
摘要翻译： 描述了包括从至少一个运动传感器接收数据的运动上下文逻辑的装置。 运动上下文逻辑确定用户的运动上下文。 基于上下文的动作逻辑基于用户的运动环境管理设备。
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公开(公告)号：US20140046223A1
公开(公告)日：2014-02-13
申请号：US14061701
申请日：2013-10-23
CPC分类号： A61B5/1118 , A61B5/0022 , A61B5/1038 , A61B5/1112 , A61B5/1113 , A61B5/1123 , A61B5/4866 , A61B5/6898 , A61B5/7221 , A61B5/7278 , A61B2562/0219 , A61B2562/08 , G01S19/49 , G06F19/00 , G16H40/67 , Y10S482/901
摘要： A mobile device monitors accelerations using one or more inertial sensors. A user activity is identified based on the accelerations. A first estimation is made of a user activity statistic associated with the user activity based on the accelerations. Location information is obtained by one or more location based sensors. A second estimation is made of the user activity statistic based on the location information. The user activity statistic is calculated based on the first estimation and the second estimation.
摘要翻译： 移动设备使用一个或多个惯性传感器来监视加速度。 基于加速度识别用户活动。 基于加速度，首先估计与用户活动相关联的用户活动统计量。 位置信息由一个或多个基于位置的传感器获得。 基于位置信息对用户活动统计量进行第二次估计。 基于第一估计和第二估计计算用户活动统计量。
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公开(公告)号：US07907901B1
公开(公告)日：2011-03-15
申请号：US11855133
申请日：2007-09-13
申请人： Philippe Kahn , Arthur Kinsolving , David Vogel
发明人： Philippe Kahn , Arthur Kinsolving , David Vogel
CPC分类号： H04M1/7253 , H04M1/6066 , H04M2250/12 , H04W4/08 , H04W12/02 , H04W12/04 , H04W24/00 , H04W64/006 , H04W76/10 , H04W84/18
摘要： A method and apparatus to provide easier pairing based on motion data is described. The method of pairing two devices comprises receiving a signal to enter into pairing mode, and detecting a motion indicating a pairing. The method further comprises establishing a secure connection with another device for pairing, the secure connection established based on the motion, and exchanging data for pairing.
摘要翻译： 描述了一种基于运动数据提供更容易配对的方法和装置。 配对两个设备的方法包括接收信号进入配对模式，以及检测指示配对的运动。 该方法还包括与另一个用于配对的设备建立安全连接，基于运动建立的安全连接以及交换数据进行配对。
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