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公开(公告)号:US20110212053A1
公开(公告)日:2011-09-01
申请号:US12737215
申请日:2009-06-19
申请人: Dapeng QIAN , Amy Qi Han , Mark Hamilton , Eric Wang
发明人: Dapeng QIAN , Amy Qi Han , Mark Hamilton , Eric Wang
IPC分类号: A61K38/20 , C07D471/04 , C12N5/09 , C07D498/04 , C07D513/04 , A61K31/437 , A61K31/506 , A61K31/496 , A61K31/501 , A61K31/5377 , A61P35/00 , A61P3/00 , A61P29/00 , A61P37/08 , A61P9/00 , A61P35/02 , A61P19/02 , A61P17/06 , A61P25/00 , A61P11/00 , A61P11/06 , A61P9/10 , A61P9/04 , A61P3/10 , A61P3/04 , A61P37/02 , A61P37/06 , A61P7/00 , A61K38/19 , A61K33/24 , A61K38/50 , A61K38/43 , A61K31/675 , A61K31/573
CPC分类号: C07D471/04 , A61K31/437 , C07D498/04 , C07D513/04
摘要: Provided are compounds according to Formula (I): or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R1, R6, R7, and R8 are as defined, and which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PI3-kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.
摘要翻译: 提供根据式(I)的化合物或其立体异构体,前药,多晶型物或其药学上可接受的盐形式,其中X,Y,R 1,R 6,R 7和R 8如上所定义,哪些化合物是PI3- 激酶和/或其他医学和临床相关的激酶。 还提供了将化合物和组合物用作PI3-激酶和激酶抑制剂的药物组合物和方法。 更具体地,本发明的化合物提供了由PI3-激酶和/或蛋白激酶或其突变体或变体形式的活性调节或与其相关的人类疾病的治疗和治疗。
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公开(公告)号:US20160304555A1
公开(公告)日:2016-10-20
申请号:US14917127
申请日:2012-08-21
申请人: Eric WANG , Hartmuth C. KOLB , Anna Katrin INGS , Changhui LIU , Joseph C. WALSH , Gang CHEN , Anjana SINHA , Dhanalakshmi KASI , Chul YU , Umesh B. GANGADHARMATH , Wei ZHANG , Tieming ZHAO , Vani P. MOCHARLA
发明人: Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
IPC分类号: C07K5/02 , A61K51/04 , A61K51/08 , C07D249/06 , C07D249/04
CPC分类号: C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
摘要: Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
摘要翻译: 公开了靶向化合物和成像剂,前列腺特异性膜抗原(PSMA)。 还公开了合成化合物和成像剂的方法以及PSMA成像方法。 所公开的成像剂适用于PET和SPECT成像。
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公开(公告)号:US08756020B2
公开(公告)日:2014-06-17
申请号:US13274309
申请日:2011-10-15
申请人: Craig Struble , Eric Wang , Andrew Sparks , Arnold Oliphant
发明人: Craig Struble , Eric Wang , Andrew Sparks , Arnold Oliphant
IPC分类号: G01N33/50
CPC分类号: G06F19/18
摘要: The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample.
摘要翻译: 本发明提供了用于确定医疗状况的更准确的风险概率的方法。 使用来自所选生物分子的频率数据和混合样品中至少一种来源的生物分子来源贡献来计算存在或不存在医学状况的风险概率。
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公开(公告)号:US20070257471A1
公开(公告)日:2007-11-08
申请号:US11382172
申请日:2006-05-08
申请人: Pete Myers , Eric Wang
发明人: Pete Myers , Eric Wang
IPC分类号: B62B7/00
摘要: A universal infant carrier transport is disclosed. The infant carrier transport is adapted to hold and safely retain infant carriers of various dimensions and shapes. The carrier, which can be a tri-wheel type baby stroller having a handle for convenient pushing by the parent, includes a horizontal platform extending from the tri-wheeled stroller and adapted to receive and support the bottom of the infant carrier. A rotating roll bar is provided and is positionable so as to rotate over the infant carrier and lock in place. A ratcheting mechanism is provided in the mount between the roll bar and the bottom support so as to be lockably positioned into one of a plurality of different positions depending upon the width and height of the infant carrier. An easy push button release mechanism is provided so as to release the ratchet when it is desired to remove the infant carrier from the transport.
摘要翻译: 公开了一种通用的婴儿背带运输。 婴儿背带运输适用于保持和安全地保留各种尺寸和形状的婴儿背带。 可以是三轮式婴儿车的托架,其具有便于由母体推动的手柄,包括从三轮婴儿车延伸并适于接收和支撑婴儿背带的底部的水平平台。 提供旋转的滚动杆,并且可定位以便在婴儿背带上旋转并锁定到位。 棘轮机构设置在辊杆和底部支撑件之间的安装件中,以便根据婴儿承载架的宽度和高度被可锁定地定位在多个不同位置之一中。 提供容易的按钮释放机构,以便当希望从运输工具移除婴儿托架时释放棘轮。
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公开(公告)号:US07272268B2
公开(公告)日:2007-09-18
申请号:US11282675
申请日:2005-11-21
申请人: Keren O. Perlmutter , Sharon M. Perlmutter , Eric Wang , Paul R. Klamer , Christopher J. Cookson , Massimiliano Gasparri
发明人: Keren O. Perlmutter , Sharon M. Perlmutter , Eric Wang , Paul R. Klamer , Christopher J. Cookson , Massimiliano Gasparri
IPC分类号: G06K9/32
CPC分类号: G06T7/38 , G06K9/32 , G06T3/403 , G06T3/4084 , G06T5/003 , G06T5/10 , G06T5/50 , G06T7/12 , G06T7/13 , G06T2207/10016 , G06T2207/10024 , G06T2207/20064 , G06T2207/20192 , H04N1/58 , H04N5/262 , H04N9/093 , H04N9/11
摘要: Separations or images relating to film or other fields may be registered using a variety of features, such as, for example: (1) correcting one or more film distortions; (2) automatically determining a transformation to reduce a film distortion; (3) applying multiple criteria of merit to a set of features to determine a set of features to use in determining a transformation; (4) determining transformations for areas in an image or a separation in a radial order; (5) comparing areas in images or separations by weighting feature pixels differently than non-feature pixels; (6) determining distortion values for transformations by applying a partial distortion measure and/or using a spiral search configuration; (7) determining transformations by using different sets of features to determine corresponding transformation parameters in an iterative manner; and (8) applying a feathering technique to neighboring areas within an image or separation.
摘要翻译: 可以使用各种特征来记录与胶片或其他领域有关的分离或图像,例如:(1)校正一个或多个胶片失真; (2)自动确定变换以减少胶片失真; (3)将多个品质标准应用于一组特征以确定用于确定变换的一组特征; (4)确定图像中的区域的转换或以径向顺序的分离; (5)通过与非特征像素不同地加权特征像素来比较图像或分离中的区域; (6)通过应用部分失真测量和/或使用螺旋搜索配置来确定变换的失真值; (7)通过使用不同的特征集确定变换,以迭代方式确定相应的变换参数; 和(8)对图像或分离中的相邻区域应用羽化技术。
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公开(公告)号:US20060186858A1
公开(公告)日:2006-08-24
申请号:US11317967
申请日:2005-12-23
申请人: Eric Wang , Ming-Chung Wang
发明人: Eric Wang , Ming-Chung Wang
IPC分类号: H02J7/00
CPC分类号: H02J7/0004
摘要: A charging apparatus includes a device-specific bridging unit and a charging unit. The bridging unit is coupled electrically and removably to a charging port of an electronic device, and is operable so as to provide charging information that is specific to the electronic device. The charging unit is coupled electrically and removably to the bridging unit, and is operable so as to generate a charging signal that is based on the charging information received from the bridging unit and that is to be supplied to the electronic device through the bridging unit.
摘要翻译: 充电装置包括特定于设备的桥接单元和充电单元。 桥接单元电连接并可移除地耦合到电子设备的充电端口,并且可操作以提供特定于电子设备的计费信息。 充电单元电连接并可拆卸地耦合到桥接单元,并且可操作以产生基于从桥接单元接收的计费信息并且将通过桥接单元提供给电子设备的充电信号。
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公开(公告)号:US20060120626A1
公开(公告)日:2006-06-08
申请号:US11341461
申请日:2006-01-30
申请人: Keren Perlmutter , Sharon Perlmutter , Eric Wang , Paul Klamer , Leng Chua
发明人: Keren Perlmutter , Sharon Perlmutter , Eric Wang , Paul Klamer , Leng Chua
IPC分类号: G06K9/32
CPC分类号: H04N1/58 , G06K9/00758 , G06K9/32 , G06T3/00 , G06T3/403 , G06T7/32 , G06T2207/10024 , H04N5/262
摘要: Images may be registered using temporal (time-based) and spatial information. In a film implementation, because film is a sequence of frames, using information from neighboring frames may enable a temporally smoother visual experience. In addition, it may be beneficial to take advantage of the fact that consecutive frames are often shifted similarly during the photographic process. Distortion measures may be used that discount candidate transformations that are considered to be too far from one or more preferred transformations, such as, for example, an optimal transformation from another frame or block or a currently-optimal transformation from the same frame/block. Composite color images may be processed to provide registration of underlying components.
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公开(公告)号:US20060072850A1
公开(公告)日:2006-04-06
申请号:US11282675
申请日:2005-11-21
申请人: Keren Perlmutter , Sharon Perlmutter , Eric Wang , Paul Klamer
发明人: Keren Perlmutter , Sharon Perlmutter , Eric Wang , Paul Klamer
IPC分类号: G06K9/32
CPC分类号: G06T7/38 , G06K9/32 , G06T3/403 , G06T3/4084 , G06T5/003 , G06T5/10 , G06T5/50 , G06T7/12 , G06T7/13 , G06T2207/10016 , G06T2207/10024 , G06T2207/20064 , G06T2207/20192 , H04N1/58 , H04N5/262 , H04N9/093 , H04N9/11
摘要: Separations or images relating to film or other fields may be registered using a variety of features, such as, for example: (1) correcting one or more film distortions; (2) automatically determining a transformation to reduce a film distortion; (3) applying multiple criteria of merit to a set of features to determine a set of features to use in determining a transformation; (4) determining transformations for areas in an image or a separation in a radial order; (5) comparing areas in images or separations by weighting feature pixels differently than non-feature pixels; (6) determining distortion values for transformations by applying a partial distortion measure and/or using a spiral search configuration; (7) determining transformations by using different sets of features to determine corresponding transformation parameters in an iterative manner; and (8) applying a feathering technique to neighboring areas within an image or separation.
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公开(公告)号:US06956976B2
公开(公告)日:2005-10-18
申请号:US10657138
申请日:2003-09-09
CPC分类号: H04N5/262 , G06T3/403 , G06T3/4084 , G06T7/13 , G06T2207/20064 , H04N1/58
摘要: Certain disclosed implementations use digital image processing to reduce the differential resolution among separations or images in film frames, such as, for example, red flare. A location in the red image may be selected using information from another image. The selected location may be modified using information from that other image. The selection may include comparing features of an edge in the first image with features of a corresponding edge in the other image. The modification may include performing wavelet transformations of the two images and copying certain coefficients (or a function of these coefficients) produced by the application of the transformation to the second image to the coefficients produced by the application of the transformation to the first image. The copied coefficients may be correlated with the selected location. Other disclosed techniques vary from the above and may be applied to other fields.
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公开(公告)号:US06923690B1
公开(公告)日:2005-08-02
申请号:US10893406
申请日:2004-07-16
申请人: Eric Wang
发明人: Eric Wang
IPC分类号: H01R13/24
CPC分类号: H01R13/2421 , H01R2201/16
摘要: A spring-loaded electrical contact includes a conductive terminal disposed movably in a receiving space that is confined by a U-shaped base part of a conductive mounting seat. The conductive terminal is operable to move from a released state, where a first end portion of the conductive terminal is spaced apart from an intermediate plate portion of the base part, to a pressed state, where the first end portion of the conductive terminal is proximate to the intermediate plate portion of the base part and where an intermediate stop portion of the conductive terminal is clamped between two clamping pieces formed respectively on two lateral plate portions of the base part. A biasing member is disposed in the receiving space and is mounted between the intermediate stop portion and the intermediate plate portion for biasing the conductive terminal to the released state.
摘要翻译: 弹簧加载的电触头包括可移动地设置在由导电安装座的U形基部限定的容纳空间中的导电端子。 导电端子可操作以从导电端子的第一端部与基部的中间板部分间隔开的释放状态移动到压接状态,其中导电端子的第一端部接近 到基部的中间板部分,并且导电端子的中间停止部分夹在分别形成在基部的两个侧板部分上的两个夹紧片之间。 偏压构件设置在容纳空间中并安装在中间止挡部分和中间板部分之间,用于将导电端子偏压到释放状态。
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