公开(公告)号：US20100331834A1

公开(公告)日：2010-12-30

申请号：US12493302

申请日：2009-06-29

申请人： Darion Peterson ,  Joseph D. Brannan ,  Kenlyn S. Bonn ,  Richard W. Wetz ,  Francesca Rossetto ,  Ian Smith

发明人： Darion Peterson ,  Joseph D. Brannan ,  Kenlyn S. Bonn ,  Richard W. Wetz ,  Francesca Rossetto ,  Ian Smith

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B90/50 ,  A61B2018/1425 ,  A61B2018/1869 ,  A61B2090/508

摘要： An ablation probe fixation apparatus for securing an ablation probe to tissue is disclosed. The ablation probe fixation apparatus includes a base having a top surface and a skin-contacting bottom surface, wherein the base includes an adhesive layer disposed on the skin-contacting bottom surface. The fixation apparatus also includes a fixation member coupled to the top surface of the base. The base and the fixation member include an aperture defined therein for insertion of the ablation probe therethrough.

摘要翻译： 公开了一种用于将消融探针固定到组织的消融探针固定装置。 消融探针固定装置包括具有顶表面和与皮肤接触的底表面的基部，其中基部包括设置在皮肤接触的底表面上的粘合剂层。 固定装置还包括联接到基座的顶表面的固定构件。 基部和固定构件包括限定在其中的孔，用于通过其插入消融探针。

公开(公告)号：US20100234839A1

公开(公告)日：2010-09-16

申请号：US12401268

申请日：2009-03-10

申请人： Ian Smith ,  Joseph D. Brannan

发明人： Ian Smith ,  Joseph D. Brannan

IPC分类号： A61B18/18 ,  H01P11/00

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/1838 ,  A61N5/045 ,  H01Q9/16 ,  Y10T29/49005 ,  Y10T29/49016 ,  Y10T29/49018

摘要： Microwave antenna assemblies incorporating a resilient insulating coupler are described herein. The microwave antenna includes a radiating portion connected by a coaxial feedline to a power generating source, e.g., a generator. Distal and proximal radiating portions of the antenna, which correspond to inner and outer conductors provided by the coaxial feedline, are separated by the resilient insulating coupler. The described coupler includes a proximal threaded portion, and an overmolded insulating portion formed from an elastomeric material. The inner conductor of the coaxial feedline is joined to the threaded portion of the coupler, and is placed under tension to draw together the distal radiating portion, the coupler, and the proximal radiating portion into a single rigid assembly. In use, the resilient coupler provides increased strength and reliability by absorbing mechanical stresses typically encountered during microwave ablation procedures.

摘要翻译： 本文描述了包含弹性绝缘耦合器的微波天线组件。 微波天线包括通过同轴馈线连接到发电源（例如发电机）的辐射部分。 对应于由同轴馈线提供的内导体和外导体的天线的远端和近端辐射部分由弹性绝缘耦合器分开。 所描述的耦合器包括近端螺纹部分和由弹性材料形成的包覆成型的绝缘部分。 同轴馈线的内导体连接到耦合器的螺纹部分，并且被放置在张力下以将远侧辐射部分，耦合器和近侧辐射部分拉到一个刚性组件中。 在使用中，弹性耦合器通过吸收通常在微波消融过程中遇到的机械应力而提供增强的强度和可靠性。

公开(公告)号：US08118808B2

公开(公告)日：2012-02-21

申请号：US12401268

申请日：2009-03-10

申请人： Ian Smith ,  Joseph D. Brannan

发明人： Ian Smith ,  Joseph D. Brannan

IPC分类号： A61B18/04 ,  A61B18/18 ,  A61F2/00

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/1838 ,  A61N5/045 ,  H01Q9/16 ,  Y10T29/49005 ,  Y10T29/49016 ,  Y10T29/49018

摘要： Microwave antenna assemblies incorporating a resilient insulating coupler are described herein. The microwave antenna includes a radiating portion connected by a coaxial feedline to a power generating source, e.g., a generator. Distal and proximal radiating portions of the antenna, which correspond to inner and outer conductors provided by the coaxial feedline, are separated by the resilient insulating coupler. The described coupler includes a proximal threaded portion, and an overmolded insulating portion formed from an elastomeric material. The inner conductor of the coaxial feedline is joined to the threaded portion of the coupler, and is placed under tension to draw together the distal radiating portion, the coupler, and the proximal radiating portion into a single rigid assembly. In use, the resilient coupler provides increased strength and reliability by absorbing mechanical stresses typically encountered during microwave ablation procedures.

摘要翻译： 本文描述了包含弹性绝缘耦合器的微波天线组件。 微波天线包括通过同轴馈线连接到发电源（例如发电机）的辐射部分。 对应于由同轴馈线提供的内导体和外导体的天线的远端和近端辐射部分由弹性绝缘耦合器分开。 所描述的耦合器包括近端螺纹部分和由弹性材料形成的包覆成型的绝缘部分。 同轴馈线的内导体连接到耦合器的螺纹部分，并且被放置在张力下以将远侧辐射部分，耦合器和近侧辐射部分拉到一个刚性组件中。 在使用中，弹性耦合器通过吸收通常在微波消融过程中遇到的机械应力而提供增强的强度和可靠性。

公开(公告)号：US08832927B2

公开(公告)日：2014-09-16

申请号：US13351463

申请日：2012-01-17

申请人： Ian Smith ,  Joseph D. Brannan

发明人： Ian Smith ,  Joseph D. Brannan

IPC分类号： H01P11/00 ,  A61B18/18 ,  H01Q9/16 ,  A61N5/04 ,  A61B18/00

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/1838 ,  A61N5/045 ,  H01Q9/16 ,  Y10T29/49005 ,  Y10T29/49016 ,  Y10T29/49018

摘要： A method of manufacturing a surgical antenna includes bonding a trocar screw and a conductor together and overmolding the trocar screw with a puck material to form a puck assembly. A trocar is coupled to the trocar screw, which forms a distal radiating section, and a proximal antenna member is coupled to the puck assembly, which forms a proximal radiating section.

摘要翻译： 一种外科天线的制造方法包括将套管针螺钉和导体接合在一起，并用套盘材料包覆成型套管针螺钉以形成圆盘组件。 套管针与套管针螺丝连接，套管针螺钉形成远侧辐射部分，近端天线部件联接到形成近端辐射部分的圆盘组件。

公开(公告)号：US20120110834A1

公开(公告)日：2012-05-10

申请号：US13351463

申请日：2012-01-17

申请人： Ian Smith ,  Joseph D. Brannan

发明人： Ian Smith ,  Joseph D. Brannan

IPC分类号： H01P11/00

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/1838 ,  A61N5/045 ,  H01Q9/16 ,  Y10T29/49005 ,  Y10T29/49016 ,  Y10T29/49018

摘要： Microwave antenna assemblies incorporating a resilient insulating coupler are described herein. The microwave antenna includes a radiating portion connected by a coaxial feedline to a power generating source, e.g., a generator. Distal and proximal radiating portions of the antenna, which correspond to inner and outer conductors provided by the coaxial feedline, are separated by the resilient insulating coupler. The described coupler includes a proximal threaded portion, and an overmolded insulating portion formed from an elastomeric material. The inner conductor of the coaxial feedline is joined to the threaded portion of the coupler, and is placed under tension to draw together the distal radiating portion, the coupler, and the proximal radiating portion into a single rigid assembly. In use, the resilient coupler provides increased strength and reliability by absorbing mechanical stresses typically encountered during microwave ablation procedures.

摘要翻译： 本文描述了包含弹性绝缘耦合器的微波天线组件。 微波天线包括通过同轴馈线连接到发电源（例如发电机）的辐射部分。 对应于由同轴馈线提供的内导体和外导体的天线的远端和近端辐射部分由弹性绝缘耦合器分开。 所描述的耦合器包括近端螺纹部分和由弹性材料形成的包覆成型的绝缘部分。 同轴馈线的内导体连接到耦合器的螺纹部分，并且被放置在张力下以将远侧辐射部分，耦合器和近侧辐射部分拉到一个刚性组件中。 在使用中，弹性耦合器通过吸收通常在微波消融过程中遇到的机械应力而提供增强的强度和可靠性。

公开(公告)号：US09561336B2

公开(公告)日：2017-02-07

申请号：US13380083

申请日：2010-06-24

申请人： Ian Smith

发明人： Ian Smith

IPC分类号： A61M15/00

CPC分类号： A61M15/0045 ,  A61M15/0003 ,  A61M15/0031 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0061 ,  A61M2202/064

摘要： Various embodiments relate to a dose unit for a dry powder inhaler including: a dose carrier including a plurality of pockets each adapted to contain a dose of medication powder suitable for inhalation, the pockets being sequentially arranged such that the content of the pockets can be sequentially exposed to a flow of air for successive inhalations and a plurality of medication powder doses arranged in the pockets of the dose carrier. The doses are regularly distributed in the pockets according to a sequence of identical groups, each group including at least one blank pocket and one pocket containing a dose of medication powder. Various embodiments also relate to a pack including one such dose unit and one further dose unit with all pockets containing a medication powder. Various embodiments further relate to a dry powder inhaler including such a pack of dose units.

摘要翻译： 各种实施方案涉及用于干粉吸入器的剂量单位，包括：剂量载体，其包括多个口袋，每个口袋适于容纳适于吸入的一定剂量的药用粉末，所述口袋顺序地布置成使得口袋的内容可以顺序地 暴露于用于连续吸入的空气流和布置在剂量载体的袋中的多个药粉剂量。 剂量根据相同组的顺序规则分布在口袋中，每组包括至少一个空白口袋和一个含有一定剂量的药粉的口袋。 各种实施方案还涉及一种包括一种这样的剂量单位和一个另外的剂量单位，其中所有口袋含有药物粉末。 各种实施方案进一步涉及包含这样一组剂量单位的干粉吸入器。

公开(公告)号：US20100159272A1

公开(公告)日：2010-06-24

申请号：US12653894

申请日：2009-12-17

申请人： Pierre Henri Marois ,  Kevin Michael Gatenby ,  Thomas L. Davisson ,  Andrew D. Howells ,  Ian Smith

发明人： Pierre Henri Marois ,  Kevin Michael Gatenby ,  Thomas L. Davisson ,  Andrew D. Howells ,  Ian Smith

IPC分类号： B32B15/01 ,  B32B1/08 ,  B32B15/20

CPC分类号： C22C21/10 ,  B23K1/0012 ,  B23K35/0238 ,  B23K35/286 ,  B32B15/016 ,  C22C21/00 ,  C22C21/02 ,  C22C21/12 ,  C23F13/08 ,  C23F13/14 ,  C23F2213/32 ,  F28F19/06 ,  F28F21/084 ,  F28F21/089 ,  Y10T428/12736 ,  Y10T428/1275 ,  Y10T428/12764

摘要： The exemplary embodiments relate to a multilayer aluminum alloy sheet material suitable for fabrication into coolant-conveying tubes, headers and the like used for heat exchangers, and to the tubes and headers, etc., fabricated from the sheet. The multi-layer metal sheet has a core layer of aluminum alloy having first and second sides. The first side has an interlayer made of a Zn-containing aluminum alloy positioned between a Zn-containing outer layer and the core layer. The alloy of the outer layer is more electronegative than the alloy of the interlayer. The alloy of the interlayer is preferably more electronegative than the alloy of the core layer. The first side clad in this way is the side intended for exposure to the coolant, and provides good resistance to corrosion and erosion.

摘要翻译： 示例性实施例涉及适于制造用于热交换器的冷却剂输送管，集管等的多层铝合金板材以及由板制成的管和集管等。 多层金属片具有第一和第二侧的铝合金芯层。 第一面具有由位于含Zn外层和芯层之间的含Zn铝合金制成的中间层。 外层的合金比中间层的合金更具电负性。 中间层的合金优选比核心层的合金更具有电负性。 以这种方式包覆的第一面是用于暴露于冷却剂的侧面，并且提供良好的耐腐蚀和侵蚀性。

公开(公告)号：US20080138465A1

公开(公告)日：2008-06-12

申请号：US11923229

申请日：2007-10-24

申请人： Paul D. Soper ,  Vesselin Danailov Miladinov ,  Jose A. Amarista ,  Ian Smith ,  Carole Elleman ,  Mark Taylor ,  Nigel Kenneth Harry Slater ,  Mark Edward Eccleston

发明人： Paul D. Soper ,  Vesselin Danailov Miladinov ,  Jose A. Amarista ,  Ian Smith ,  Carole Elleman ,  Mark Taylor ,  Nigel Kenneth Harry Slater ,  Mark Edward Eccleston

IPC分类号： A23G4/18

CPC分类号： A23G4/08

摘要： The present invention provides gum base compositions and chewing gum compositions having non stick or reduced-stick properties and/or increased degradability. Methods of preparing the gum base and chewing gum compositions, as well as methods of use, are provided.

摘要翻译： 本发明提供了胶基组合物和口香糖组合物，其具有不粘或降粘性质和/或增加的降解性。 提供了制备胶基和口香糖组合物的方法，以及使用方法。

公开(公告)号：US07301634B2

公开(公告)日：2007-11-27

申请号：US10785821

申请日：2004-02-23

申请人： Walter D. Mieher ,  Ady Levy ,  Boris Golovanesky ,  Michael Friedmann ,  Ian Smith ,  Michael E. Adel ,  Christopher F. Bevis ,  John Fielden ,  Noah Bareket ,  Anatoly Fabrikant ,  Mark Ghinovker ,  Piotr Zalicki ,  Dan Wack

发明人： Walter D. Mieher ,  Ady Levy ,  Boris Golovanesky ,  Michael Friedmann ,  Ian Smith ,  Michael E. Adel ,  Christopher F. Bevis ,  John Fielden ,  Noah Bareket ,  Anatoly Fabrikant ,  Mark Ghinovker ,  Piotr Zalicki ,  Dan Wack

IPC分类号： G01B11/00

CPC分类号： G03F9/7088 ,  G01N21/956 ,  G01N2021/213 ,  G03F7/70625 ,  G03F7/70633 ,  G03F7/70683 ,  G03F9/7049 ,  G03F9/7084

摘要： Disclosed is a method of determining an overlay error between two layers of a multiple layer sample. For a plurality of periodic targets that each have a first structure formed from a first layer and a second structure formed from a second layer of the sample, an interferometer is employed to modulate substantially a plurality of wavelengths of a broadband source and then acquiring one or more images of the periodic targets. There are predefined offsets between the first and second structures. An overlay error between the first and second structures is then determined by analyzing the one or more acquired images from the periodic targets using a scatterometry overlay technique based on the predefined offsets.

摘要翻译： 公开了一种确定多层样本的两层之间的覆盖误差的方法。 对于每个具有由第一层形成的第一结构和由样本的第二层形成的第二结构的多个周期性目标，使用干涉仪来调制宽带源的基本上多个波长，然后获取一个或 更多图像的周期性目标。 在第一和第二结构之间有预定义的偏移。 然后通过使用基于预定义的偏移的散射测量覆盖技术来分析来自周期性目标的一个或多个获取的图像来确定第一和第二结构之间的重叠误差。

公开(公告)号：US20070191608A1

公开(公告)日：2007-08-16

申请号：US10561051

申请日：2004-06-18

申请人： Graham Evans ,  Ian Smith ,  Neil Tremayne ,  Leighton Jones ,  Marianne Langston

发明人： Graham Evans ,  Ian Smith ,  Neil Tremayne ,  Leighton Jones ,  Marianne Langston

IPC分类号： C07D471/02 ,  C07D213/63

CPC分类号： C07D495/04 ,  C07D213/85

摘要： This invention provides a class of 3-amino-7H-thieno[2,3-b]pyridin-6-one derivatives, substituted in the 7-position by an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety, and in the 2-position by a specified range of substituent groups; also provided is a process for preparing those compounds, and the use thereof as intermediates in the manufacture of certain p38 MAP kinase inhibitors.

摘要翻译： 本发明提供一类3-位氨基-7H-噻吩并[2,3-b]吡啶-6-酮衍生物，其在7-位被芳基，杂芳基，环烷基或杂环烷基部分取代，并且在2-位上 通过指定范围的取代基; 还提供了制备这些化合物的方法，以及作为制备某些p38MAP激酶抑制剂的中间体的用途。