公开(公告)号：US20060247440A1

公开(公告)日：2006-11-02

申请号：US11205764

申请日：2005-08-17

申请人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Or ,  Zhe Wang

发明人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Or ,  Zhe Wang

IPC分类号： C07D403/04 ,  C07D401/00

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

摘要翻译： 本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

公开(公告)号：US07538225B2

公开(公告)日：2009-05-26

申请号：US11205764

申请日：2005-08-17

申请人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

发明人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

摘要翻译： 本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

公开(公告)号：US20080242865A1

公开(公告)日：2008-10-02

申请号：US12135299

申请日：2008-06-09

申请人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

发明人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

摘要翻译： 本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

公开(公告)号：US07919627B2

公开(公告)日：2011-04-05

申请号：US12135299

申请日：2008-06-09

申请人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

发明人： Datong Tang ,  Yao-Ling Qiu ,  Heejin Kim ,  Yat Sun Or ,  Zhe Wang

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):

摘要翻译： 本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。 特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

公开(公告)号：US20050159370A1

公开(公告)日：2005-07-21

申请号：US11042720

申请日：2005-01-25

申请人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

发明人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

IPC分类号： A61K31/7052 ,  A61K45/06 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US20050037982A1

公开(公告)日：2005-02-17

申请号：US10429485

申请日：2003-05-05

申请人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

发明人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

IPC分类号： C07H17/08 ,  A61K31/7048

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US20050171033A1

公开(公告)日：2005-08-04

申请号：US11031465

申请日：2005-01-07

申请人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Phan ,  Yat Or

发明人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Phan ,  Yat Or

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋物，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20080039406A1

公开(公告)日：2008-02-14

申请号：US11828473

申请日：2007-07-26

申请人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

发明人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

IPC分类号： A61K31/7048 ,  A61P25/00 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20060069048A1

公开(公告)日：2006-03-30

申请号：US11236043

申请日：2005-09-27

申请人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

发明人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

IPC分类号： C07H17/08 ,  A61K31/7052

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：

公开(公告)号：US20050020823A1

公开(公告)日：2005-01-27

申请号：US10840948

申请日：2004-05-07

申请人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

发明人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

IPC分类号： A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08

摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法