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公开(公告)号：US20050065322A1
公开(公告)日：2005-03-24
申请号：US10969164
申请日：2004-10-20
申请人： David Adler , Paul Sheppard
发明人： David Adler , Paul Sheppard
CPC分类号： C07K14/47
摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig63, a novel secreted salivary protein. The polypeptides, and polynucleotides encoding them, may exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The polynucleotides encoding zsig63, are located on chromosome 4, and can be used to identify a region of the genome associated with human disease states. The present invention also includes antibodies to the zsig63 polypeptides.
摘要翻译： 本发明涉及用于zsig63（一种新型分泌的唾液蛋白）的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸可以表现出抗微生物活性，并且可以用于研究或治疗微生物感染。 编码zsig63的多核苷酸位于染色体4上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括针对zsig63多肽的抗体。
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公开(公告)号：US20060223987A1
公开(公告)日：2006-10-05
申请号：US11450178
申请日：2006-06-09
CPC分类号： C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
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公开(公告)号：US20070254340A1
公开(公告)日：2007-11-01
申请号：US11539093
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C12P21/00
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070141056A1
公开(公告)日：2007-06-21
申请号：US11552362
申请日：2006-10-24
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。多肽的多聚体也被公开。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20070117967A1
公开(公告)日：2007-05-24
申请号：US11551129
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号：US20070065404A1
公开(公告)日：2007-03-22
申请号：US11548819
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070055052A1
公开(公告)日：2007-03-08
申请号：US11550877
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号：US20070053875A1
公开(公告)日：2007-03-08
申请号：US11550186
申请日：2006-10-17
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号：US20070049737A1
公开(公告)日：2007-03-01
申请号：US11550892
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号：US20070048841A1
公开(公告)日：2007-03-01
申请号：US11548056
申请日：2006-10-10
申请人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
发明人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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