公开(公告)号：US20150316908A1

公开(公告)日：2015-11-05

申请号：US13884530

申请日：2011-11-14

申请人： Theodore Eller ,  Charles Hart ,  William Pfarr ,  Jimmie H. Spraker

发明人： Theodore Eller ,  Charles Hart ,  William Pfarr ,  Jimmie H. Spraker

IPC分类号： G05B15/02 ,  H04W4/00

CPC分类号： G05B15/02 ,  F04B49/06 ,  H04W4/80

摘要： A sensor system includes a sensor module disposed in a compartment. The sensor module includes first and second sensors, a first processor, and a first transceiver. The second sensor is separated from the first sensor in the compartment. The first processor is configured to monitor the first and second sensors. The first transceiver is configured to transmit sensor data from the first processor to a location remote from said compartment.

摘要翻译： 传感器系统包括设置在隔室中的传感器模块。 传感器模块包括第一和第二传感器，第一处理器和第一收发器。 第二个传感器与隔室中的第一个传感器分离。 第一处理器被配置为监视第一和第二传感器。 第一收发器被配置为将传感器数据从第一处理器发送到远离所述隔间的位置。

公开(公告)号：US20080091236A1

公开(公告)日：2008-04-17

申请号：US11954457

申请日：2007-12-12

申请人： Charles Hart ,  Said Hilal

发明人： Charles Hart ,  Said Hilal

IPC分类号： A61B17/04

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0487 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0488

摘要： A surgical clip having a sliding state and a crimped state is adapted for use in a surgical procedure initially to slide along suture ends to an operative position and ultimately to crimp the suture ends at the operative position. a sub straight, bendable between the sliding state and the crimped state carries at least one coating having either lubricious or traction enhancing properties. A second coating can be added to form a coating laminate with the outer coating having lubricious properties facilitating the sliding state and the inner coating having traction enhancing properties facilitating thee crimped state.

摘要翻译： 具有滑动状态和卷曲状态的手术夹具适于在外科手术过程中用于最初沿着缝合线端部滑动到操作位置，并且最终将缝线端部压缩在操作位置。 在滑动状态和卷曲状态之间可弯曲的副直线运送至少一个具有光滑或牵引增强特性的涂层。 可以添加第二涂层以形成涂层层压体，其中外涂层具有促进滑动状态的润滑性质，并且内涂层具有促进卷曲状态的牵引增强性质。

公开(公告)号：US20070244426A1

公开(公告)日：2007-10-18

申请号：US11279600

申请日：2006-04-13

申请人： Charles Hart ,  John Brustad ,  Jeremy Albrecht

发明人： Charles Hart ,  John Brustad ,  Jeremy Albrecht

IPC分类号： A61M1/00

CPC分类号： A61M39/24 ,  A61B17/3462 ,  A61M2039/242 ,  A61M2039/2426

摘要： A duckbill check valve and septum combination includes a hollow elastomeric body having an open proximal end, a closed distal end and a pair of opposed flat portions that form a distal edge. The distal edge includes a slit having a periphery that is smaller than the periphery of the instrument inserted therethrough. The slit provides a zero seal in the absence of an instrument and an instrument seal in the presence of an instrument. A shield including a tubular member and a plurality of blades protruding distally from the distal end of the tubular member may be placed inside the check valve and operates to center and guide the surgical instrument through the blades before expanding the slit of the check valve. An instrument inserted into the check valve stretches the distal portion of the duckbill valve to form a septum-like seal around the inserted instrument.

摘要翻译： 鸭嘴止回阀和隔膜组合包括中空弹性体，其具有敞开的近端，闭合的远端和形成远端边缘的一对相对的平坦部分。 远侧边缘包括具有小于插入其中的器械的周边的周边的狭缝。 在仪器存在的情况下，狭缝提供零密封。 包括管状构件和从管状构件的远端向远侧突出的多个叶片的护罩可以放置在止回阀的内部，并且在扩大止回阀的狭缝之前操作以使外科器械穿过叶片居中并引导。 插入止回阀中的仪器延伸鸭嘴阀的远端部分，以在插入的仪器周围形成隔垫状的密封。

公开(公告)号：US20070225650A1

公开(公告)日：2007-09-27

申请号：US11277116

申请日：2006-03-21

申请人： Charles Hart ,  Gigi Au ,  Kennii Pravongviengkham ,  Jeremy Albrecht

发明人： Charles Hart ,  Gigi Au ,  Kennii Pravongviengkham ,  Jeremy Albrecht

IPC分类号： A61M29/00 ,  A61M5/32 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61B17/3421 ,  A61B2017/00557 ,  A61B2017/3419 ,  A61B2017/3482 ,  A61B2017/3486 ,  A61B2017/349 ,  A61B2017/3492

摘要： A stabilization seal is used with existing cannulas for forming a gas-tight seal with tissue in a body wall The stabilization seal includes a cylindrical inflatable elongate tube having a graduated wall-thickness that is thicker in a central region and thinner in a distal-end region. The tube includes a sealing cuff, having an inflation port, for sealing around a cannula. Application of inflation pressure greatly expands the distal-end region while the central region expands slightly. Another embodiment of a stabilization seal includes an inflatable thread that is used with a cannula having a helical channel on its outer surface. An inflatable tube is wound into the channel. A distal end of the tube includes a gas-tight seal and a proximal end of the tube includes an inflation port In the uninflated condition the nested tube is flush with the channel. Inflating the tube enlarges the cannula assembly.

摘要翻译： 与现有插管一起使用稳定密封件，用于与体壁中的组织形成气密密封。稳定密封件包括圆柱形可充气细长管，其具有在中心区域较厚并且在远端较薄的梯度壁厚度 地区。 该管包括密封箍，其具有用于围绕套管密封的充气端口。 通气压力的应用大大扩大了远端地区，而中部地区略有扩张。 稳定密封件的另一实施例包括可与其外表面上具有螺旋通道的套管一起使用的可充气螺纹。 充气管缠绕在通道中。 管的远端包括气密密封，并且管的近端包括充气端口在未膨胀状态下，嵌套管与通道齐平。 充气管扩大插管组件。

公开(公告)号：US20070149859A1

公开(公告)日：2007-06-28

申请号：US11548765

申请日：2006-10-12

申请人： Jeremy Albrecht ,  Charles Hart ,  John Brustad ,  Gary Johnson

发明人： Jeremy Albrecht ,  Charles Hart ,  John Brustad ,  Gary Johnson

IPC分类号： A61B1/32

CPC分类号： A61B17/0293 ,  A61B17/02 ,  A61B17/0218 ,  A61B17/3423 ,  A61B17/3431 ,  A61B17/3439 ,  A61B17/3462 ,  A61B17/3496 ,  A61B17/3498 ,  A61B90/40 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0225 ,  A61B2017/0287 ,  A61B2017/3419 ,  A61B2017/347 ,  A61B2050/005 ,  A61B2050/0051

摘要： An incrementally adjustable wound retractor, which provides access to a body cavity, includes an inner ring having a diameter greater than the desired diameter of the wound incision, an outer ring having an annular axis and a diameter greater than the desired diameter of the wound incision, and a flexible sleeve disposed in a generally cylindrical form between the inner and outer rings. The outer ring includes first and second circular tubes spaced apart axially with each including a lumen having a rigid, noncompliant split hoop placed therein. The outer ring may be rolled over itself and around the annular axis to retract the sleeve with sufficient force to stretch the incision to the desired diameter. A gel cap seal may be coupled to the outer ring outside of the biological body to seal the opening produced by the wound retractor between the body cavity and outside the body cavity.

摘要翻译： 提供进入体腔的增量可调的伤口牵开器包括直径大于所述伤口切口所需直径的内环，具有环形轴线的外环和直径大于伤口切口的期望直径的内环 以及在内环和外环之间以大致圆柱形的形式设置的柔性套管。 外环包括轴向间隔开的第一和第二圆形管，每个包括内腔，其具有放置在其中的刚性，不一致的分割箍。 外环可以自身滚动并围绕环形轴线以足够的力使套筒缩回以将切口拉伸到期望的直径。 凝胶帽密封件可以联接到生物体外部的外环，以密封由卷绕牵开器在体腔和体腔外部产生的开口。

公开(公告)号：US20070141056A1

公开(公告)日：2007-06-21

申请号：US11552362

申请日：2006-10-24

申请人： Zeren Gao ,  Charles Hart ,  Christopher Piddington ,  Paul Sheppard ,  Kimberly Shoemaker

发明人： Zeren Gao ,  Charles Hart ,  Christopher Piddington ,  Paul Sheppard ,  Kimberly Shoemaker

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K14/52 ,  A01K2217/05 ,  A61K38/1858 ,  C07K14/475 ,  C12N2799/022

摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。多肽的多聚体也被公开。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

公开(公告)号：US20070048830A1

公开(公告)日：2007-03-01

申请号：US11550246

申请日：2006-10-17

申请人： Teresa Gilbert ,  Charles Hart ,  Paul Sheppard ,  Debra Gilbertson

发明人： Teresa Gilbert ,  Charles Hart ,  Paul Sheppard ,  Debra Gilbertson

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/475

CPC分类号： C04B38/06 ,  A61K38/177 ,  A61K38/18 ,  A61K38/1866 ,  A61K38/22 ,  C04B2111/00224 ,  C04B2111/00612 ,  C07K14/52 ,  C07K2319/00 ,  C12N2799/022 ,  C04B20/008 ,  C04B35/2641 ,  C04B35/50 ,  C04B35/64 ,  C04B38/0054 ,  C04B38/007 ,  C04B41/4578 ,  A61K2300/00

摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

公开(公告)号：US20070048381A1

公开(公告)日：2007-03-01

申请号：US11552848

申请日：2006-10-25

申请人： Charles Hart ,  Debra Gilbertson

发明人： Charles Hart ,  Debra Gilbertson

IPC分类号： A61K38/22 ,  A61K9/14

CPC分类号： C07K14/52 ,  A01K2217/05 ,  A61K9/2027 ,  A61K38/1858 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44 ,  A61L24/108 ,  A61L27/02 ,  A61L27/14 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/02 ,  A61L2430/10 ,  A61L2430/12 ,  C07K14/475 ,  C12N2799/022 ,  G01N2001/2223 ,  A61K2300/00

摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.

摘要翻译： 公开了促进哺乳动物骨，韧带或软骨生长的方法。 所述方法包括向所述哺乳动物施用包含药理学有效量的zvegf3蛋白与药学上可接受的递送载体组合的组合物。 还公开了促进成骨细胞，破骨细胞，软骨细胞或骨髓干细胞的增殖或分化的方法，包括以有效量的zvegf3蛋白培养细胞。

公开(公告)号：US20060144501A1

公开(公告)日：2006-07-06

申请号：US11319870

申请日：2005-12-28

申请人： John Brustad ,  Payam Adlparvar ,  Wassim Aliahmad ,  Canh Tran ,  Nabil Hilal ,  Boun Pravong ,  Raffi Pinedjian ,  Charles Hart

发明人： John Brustad ,  Payam Adlparvar ,  Wassim Aliahmad ,  Canh Tran ,  Nabil Hilal ,  Boun Pravong ,  Raffi Pinedjian ,  Charles Hart

IPC分类号： B65H81/00

CPC分类号： A61M25/0012 ,  A61B17/3415 ,  A61B2017/00526 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0662 ,  B29C47/0023 ,  B29C47/004 ,  B29C47/0064 ,  B29C47/025 ,  B29C47/027 ,  B29C53/60 ,  B29C61/006 ,  B29L2023/00

摘要： A releasable mechanism such as a cap is adapted for use with an access sheath having an elongate tube and a handle structure disposed at a proximal end of the tube. The releasable mechanism is sized and configured to fit the handle structure, which is shaped like the bell of a horn, to further facilitate use with surgical instrumentation. The releasable mechanism may operate as a separate cap that snaps onto the handle structure to provide access pathways to the sheath. The releasable mechanism may also be disposed at a proximal end of a surgical instrument to be introduced into the access sheath such that it may be interlocked with the sheath. In a method of manufacturing a kink-resistant sheath, a wire is initially coated with a plastic material, the coated wire is then wrapped around a mandrel forming a plurality of windings, and the wound coated wire is heated until the plastic material melts and bonds the windings to form a wire-reinforced sheath. The plastic material is preferably polyurethane but may be a thermoplastic, a thermoset or any plastic material having hard and/or soft durometer. The wound coated wire may be heated by capturing the windings within a shrink tube or compressing the windings in a mold and heating the windings until the sheath is formed. In another aspect of the invention, a mandrel is used as part of an extrusion process. In another aspect of the invention, another coating or outside layer could be formed over the spring reinforcement by dipping in a solvent based solution. In yet another embodiment of the invention, a braid such as a polyester braid may be used instead of or in addition to the coil spring to form a kink-resistant sheath.

摘要翻译： 诸如盖的可释放机构适于与具有设置在管的近端处的细长管和手柄结构的进入护套一起使用。 所述可释放机构的尺寸和构造适合于将手柄结构（其形状像喇叭的钟形）配合，以进一步便于手术器械的使用。 可释放机构可以作为单独的盖子操作，该盖子卡扣在手柄结构上以提供到护套的通路。 可释放机构还可以设置在外科器械的近端处以被引入入口护套中，使得其可以与护套互锁。 在制造耐扭结护套的方法中，最初用塑料材料涂覆线，然后将涂覆的线缠绕在形成多个绕组的心轴上，并且加热伤口涂覆的线，直到塑料材料熔化并结合 绕组形成电线增强护套。 塑料材料优选为聚氨酯，但可以是热塑性塑料，热固性材料或具有硬和/或软硬度的任何塑料材料。 可以通过将收缩管内的绕组捕获或压缩模具中的绕组并加热绕组直到形成护套来加热伤口涂覆的线。 在本发明的另一方面，使用心轴作为挤出工艺的一部分。 在本发明的另一方面，可以通过浸渍在基于溶剂的溶液中在弹簧加强件上形成另一涂层或外层。 在本发明的另一个实施例中，可以使用诸如聚酯编织物的编织物代替螺旋弹簧或除了螺旋弹簧以外以形成扭结护套。

公开(公告)号：US20060084842A1

公开(公告)日：2006-04-20

申请号：US11245709

申请日：2005-10-07

申请人： Charles Hart ,  Edward Pingleton

发明人： Charles Hart ,  Edward Pingleton

IPC分类号： A61B1/32

CPC分类号： A61B17/0293 ,  A61B17/3423 ,  A61B17/3498 ,  A61B2017/00265

摘要： The invention is directed to a hand access system that provides hand access to a surgical area while maintaining pneumoperitoneum during laparoscopic surgery. The hand access system comprises a sheath retractor adapted to dilate a wound stretchable to a desired diameter, the sheath retractor includes a first ring being adapted for disposition interiorly of the wound, a second ring being adapted for disposition exteriorly of the wound, and a sheath being disposed in a generally cylindrical form between the first ring and the second ring and operable to exert a radial retraction force on the wound. The hand access system further comprises a detachable hand seal adapted to be removable from the second ring of the sheath retractor. The sheath retractor may be formed of an elastomeric material, and the hand seal may be formed of a gel material and includes a slit providing an instrument seal in the presence of an instrument or hand and a zero seal in the absence of the instrument or hand. In another aspect, there is disclosed a surgical access device adapted for disposition relative to an incision in a patient comprising a valve including a plurality of overlapping sheets defining an access channel, and a ring having an inner diameter for holding the valve by fixing each of the overlapping sheets along a portion of the perimeter, the access channel extends into communication with the incision in the patient. Each of the overlapping sheets includes a portion of the perimeter that is not fixed to the inner diameter of the ring, which provide open edges defining the access channel. The open edges slightly overlap at the center of the ring. The open edges may have different shapes including at least one of a straight edge, concave, convex and a cross-configuration. The hand access device may further comprise a septum seal formed at the proximal and distal ends of the ring.

摘要翻译： 本发明涉及一种手动进入系统，其在腹腔镜手术期间提供手术进入手术区域同时保持气腹。 手动进入系统包括一个适合于将可拉伸到所需直径的伤口扩张的护套牵开器，所述护套牵开器包括适于在伤口内部配置的第一环，适于在伤口外部配置的第二环， 在第一环和第二环之间以大致圆柱形的形式设置并可操作以在伤口上施加径向缩回力。 手动进入系统还包括适于从皮带牵开器的第二环移除的可拆卸手动密封件。 护套牵开器可以由弹性体材料形成，并且手动密封件可以由凝胶材料形成，并且包括在没有仪器或手的情况下在仪器或手的存在下提供仪器密封的狭缝和零密封 。 另一方面，公开了一种外科进入装置，其适于相对于患者的切口进行配置，该装置包括阀，所述阀包括限定出入通道的多个重叠片，以及具有用于通过固定每个 沿着周边的一部分重叠的片材，进入通道延伸成与患者的切口连通。 每个重叠片材包括未固定到环的内径的周边的一部分，其提供限定接入通道的开口边缘。 开口边缘在环的中心稍微重叠。 开口边缘可以具有不同的形状，包括直边，凹形，凸形和交叉构型中的至少一个。 手动进入装置还可以包括形成在环的近端和远端的隔膜密封件。