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1.发明申请DIAGNOSIS OF DISEASES AND CONDITIONS BY ANALYSIS OF HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES USING LIQUID TISSUE PREPARATIONS 有权通过使用液体组织制剂分析病理学进程的生物样品来诊断疾病和病症公开(公告)号：US20090215636A1
公开(公告)日：2009-08-27
申请号：US11915581
申请日：2006-05-25
IPC分类号： C40B30/00 , G01N1/30 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/57434 , G01N33/6803 , Y02A50/57 , Y02A50/58
摘要： The invention provides methods for diagnosing diseases such as cancer and other conditions using biological samples. Liquid Tissue samples prepared from histopathologically prepared tissue obtained from a subject surprisingly can be used to identify and, optionally, to quantify analytes that are diagnostic of the presence of a disease, condition or syndrome in the subject.
摘要翻译： 本发明提供使用生物样品诊断疾病如癌症和其他病症的方法。 液体从组织病理学制备的组织样品制备的组织样品令人惊奇地可以用于鉴定和任选地定量诊断受试者中疾病，病症或综合征的存在的分析物。
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2.发明申请MULTIPLEX LIQUID TISSUE METHOD FOR INCREASED PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES, TISSUES, AND CELLS 有权多组分液体组织方法用于从病理生物学过程生物样品，组织和细胞中增加的保护性覆盖公开(公告)号：US20090136971A1
公开(公告)日：2009-05-28
申请号：US11915582
申请日：2006-05-25
IPC分类号： G01N33/536 , C12P21/06 , G01N33/559 , G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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3.发明授权Liquid tissue preparation from histopathologically processed biological samples, tissues and cells 有权来自组织病理学处理的生物样品，组织和细胞的液体组织制备公开(公告)号：US07473532B2
公开(公告)日：2009-01-06
申请号：US10796288
申请日：2004-03-10
CPC分类号： G01N1/4044 , C12N15/1003 , C12Q1/37 , G01N1/30 , G01N1/44
摘要： The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solublization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
摘要翻译： 本发明提供了一种将组织病理学处理的生物样品，组织和细胞直接转化成多用途生物分子裂解物的方法。 该方法允许同时提取，分离，溶解和储存包含在组织病理学处理的生物样品中的所有生物分子，从而形成所述样品的代表性文库。 这种多用途生物分子裂解物是可稀释的，可溶的，能够分级，并用于任何数量的后续实验。
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4.发明授权Multiplex method for increased proteomic coverage from histopathologically processed biological samples, tissues cells 有权用于增加组织病理学处理的生物样品，组织细胞的蛋白质组覆盖率的多重法公开(公告)号：US07906301B2
公开(公告)日：2011-03-15
申请号：US11915582
申请日：2006-05-25
IPC分类号： G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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5.发明申请Liquid Tissue Preparation From Histopathologically Processed Biological Samples, Tissues and Cells 有权组织病理学处理的生物样品，组织和细胞的液体组织制备公开(公告)号：US20090197776A1
公开(公告)日：2009-08-06
申请号：US12348868
申请日：2009-01-05
CPC分类号： G01N1/4044 , C12N15/1003 , C12Q1/37 , G01N1/30 , G01N1/44
摘要： The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solublization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
摘要翻译： 本发明提供了一种将组织病理学处理的生物样品，组织和细胞直接转化成多用途生物分子裂解物的方法。 该方法允许同时提取，分离，溶解和储存包含在组织病理学处理的生物样品中的所有生物分子，从而形成所述样品的代表性文库。 这种多用途生物分子裂解物是可稀释的，可溶的，能够分级，并用于任何数量的后续实验。
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6.发明授权Multiplex liquid tissue™ method for increased proteomic coverage from histopathologically processed biological samples, tissues and cells 有权用于增加组织病理学处理的生物样品，组织和细胞的蛋白质组覆盖的多重液体组织TM方法公开(公告)号：US08293485B2
公开(公告)日：2012-10-23
申请号：US13048522
申请日：2011-03-15
IPC分类号： G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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7.发明授权Liquid tissue preparation from histopathologically processed biological samples, tissues and cells 有权来自组织病理学处理的生物样品，组织和细胞的液体组织制备公开(公告)号：US08455215B2
公开(公告)日：2013-06-04
申请号：US12348868
申请日：2009-01-05
CPC分类号： G01N1/4044 , C12N15/1003 , C12Q1/37 , G01N1/30 , G01N1/44
摘要： The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solubilization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
摘要翻译： 本发明提供了一种将组织病理学处理的生物样品，组织和细胞直接转化成多用途生物分子裂解物的方法。 该方法允许同时提取，分离，溶解和储存包含在组织病理学处理的生物样品中的所有生物分子，从而形成所述样品的代表性文库。 这种多用途生物分子裂解物是可稀释的，可溶的，能够分级，并用于任何数量的后续实验。
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8.发明授权Biological laser printing for tissue microdissection via indirect photon-biomaterial interactions 有权生物激光打印用于通过间接光子 - 生物材料相互作用进行组织显微切割公开(公告)号：US07381440B2
公开(公告)日：2008-06-03
申请号：US10863833
申请日：2004-06-04
IPC分类号： B05D3/06
CPC分类号： C23C14/048 , A61B18/20 , B01J2219/00527 , B01J2219/00603 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01J2219/00743 , B41M5/38207 , B41M5/385 , B41M5/41 , B41M5/465 , C12N13/00 , C23C14/28 , G01N1/2813 , G01N2001/2886
摘要： A method of laser forward transfer is disclosed. Photo energy is directed through a photon-transparent support and absorbed by an interlayer coated thereon. The energized interlayer causes the transfer of specific regions of a heterogeneous tissue sample coated thereon across a gap and onto a receiving substrate or into a receiving vessel.
摘要翻译： 公开了一种激光正转传输方法。 光能通过光子透明载体引导并被涂覆在其上的层间吸收。 通电中间层使得涂覆在其上的异质组织样品的特定区域跨越间隙转移到接收衬底或接收容器中。
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公开(公告)号：US20110028344A1
公开(公告)日：2011-02-03
申请号：US12937222
申请日：2009-04-13
申请人： David B. Krizman , Thomas G. Guiel
发明人： David B. Krizman , Thomas G. Guiel
CPC分类号： G01N33/57442
摘要： This patent application discloses and describes a list of proteins that are found to be differentially expressed between normal endometrial epithelial cells and early stage cancerous endometrial epithelial cells. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from endometrial cancer patients, or individuals suspected on having endometrial cancer. In addition, these proteins are also differentially expressed between normal endometrial epithelial cells and epithelial cells of other types of endometrial disease, and thus such diseases can be diagnosed using assays based on these proteins. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins. These proteins can also be identified as “companion diagnostic” proteins, wherein they are not only differentially expressed for use as diagnostic and prognostic indicators of endometrial cancer and other endometrial diseases, but the same proteins are also targets for therapeutic intervention of endometrial cancer and other endometrial diseases.
摘要翻译： 该专利申请公开并描述了发现在正常子宫内膜上皮细胞和早期癌性子宫内膜上皮细胞之间差异表达的蛋白质列表。 这些蛋白质可以在来自子宫内膜癌患者或怀疑患有子宫内膜癌的个体的各种生物样品的诊断和预后蛋白测定中单独使用或以特定组合使用。 此外，这些蛋白质也在正常子宫内膜上皮细胞和其他类型的子宫内膜疾病的上皮细胞之间差异表达，因此可以使用基于这些蛋白质的测定来诊断这些疾病。 可以测定全长完整蛋白质，或者可以将这些蛋白质衍生的肽作为这些蛋白质的报告物进行测定。 这些蛋白质也可以被鉴定为“伴侣诊断”蛋白质，其中它们不仅差异表达以用作子宫内膜癌和其他子宫内膜疾病的诊断和预后指标，而且相同的蛋白质也是子宫内膜癌和其他的治疗性干预的靶标 子宫内膜疾病
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10.发明申请Insulin-Like Growth Factor 1 Receptor (IGF1R) Protein SRM/MRM Assay 有权胰岛素样生长因子1受体（IGF1R）蛋白SRM / MRM测定公开(公告)号：US20120302650A1
公开(公告)日：2012-11-29
申请号：US13529875
申请日：2012-06-21
IPC分类号： G01N27/72 , C07K7/06 , G01N33/566 , C07K7/08 , C07K16/28 , A61P35/00 , A61K35/00 , C07K14/71
CPC分类号： G01N33/6851 , G01N33/6848 , G01N33/74 , G01N2333/71
摘要： The current disclosure provides for specific peptides from the Insulin-Like Growth Factor 1 Receptor (IGF-1R) protein and the derived ionization characteristics of those peptides that are advantageous for quantifying the IGF-1R directly in formalin fixed biological samples by the method of Selected Reaction Monitoring (SRM) mass spectrometry. Such fixed biological samples include: formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and formalin fixed and paraffin embedded tissue culture cells. IGF-1R protein is quantitated in biological samples by the method of SRM/MRM mass spectrometry by quantitating one or more of the peptides described herein. The peptides can be quantitated if they reside in a modified or an unmodified form. Examples of potentially modified forms of an IGF-1R peptides include those bearing phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.
摘要翻译： 目前的公开内容提供了来自胰岛素样生长因子1受体（IGF-1R）蛋白的特异性肽以及这些肽的衍生电离特征，其有利于通过选择的方法直接在福尔马林固定生物样品中定量IGF-1R 反应监测（SRM）质谱。 这样的固定生物样品包括：福尔马林固定的组织/细胞，福尔马林固定/石蜡包埋（FFPE）组织/细胞，FFPE组织块和来自那些块的细胞，以及福尔马林固定和石蜡包埋的组织培养细胞。 通过定量一种或多种本文所述的肽，通过SRM / MRM质谱法的方法在生物样品中定量IGF-1R蛋白质。 如果它们以修饰或未修饰的形式存在，则可定量肽。 IGF-1R肽的潜在修饰形式的实例包括在肽序列内具有酪氨酸，苏氨酸，丝氨酸和/或其他氨基酸残基的磷酸化的那些。
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