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1.发明申请MULTIPLEX LIQUID TISSUE™ METHOD FOR INCREASED PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES, TISSUES AND CELLS 有权多组分液体组织方法用于从病理生物学过程的生物样品，组织和细胞中增加的保护性覆盖物公开(公告)号：US20110229917A1
公开(公告)日：2011-09-22
申请号：US13048522
申请日：2011-03-15
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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2.发明授权Liquid tissue preparation from histopathologically processed biological samples, tissues and cells 有权来自组织病理学处理的生物样品，组织和细胞的液体组织制备公开(公告)号：US07473532B2
公开(公告)日：2009-01-06
申请号：US10796288
申请日：2004-03-10
CPC分类号： G01N1/4044 , C12N15/1003 , C12Q1/37 , G01N1/30 , G01N1/44
摘要： The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solublization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
摘要翻译： 本发明提供了一种将组织病理学处理的生物样品，组织和细胞直接转化成多用途生物分子裂解物的方法。 该方法允许同时提取，分离，溶解和储存包含在组织病理学处理的生物样品中的所有生物分子，从而形成所述样品的代表性文库。 这种多用途生物分子裂解物是可稀释的，可溶的，能够分级，并用于任何数量的后续实验。
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公开(公告)号：US20150005182A1
公开(公告)日：2015-01-01
申请号：US13932843
申请日：2013-07-01
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N2800/52 , G01N2800/54 , G01N2800/60
摘要： This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells that did not give rise to recurrent breast cancer disease after initial diagnosis and primary breast cancer cells that did give rise to recurrent breast cancer disease after initial diagnosis. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the likelihood that a breast cancer patient's cancer will recur after initial diagnosis and treatment. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the likelihood of recurrent breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins. These proteins can also be identified as “companion diagnostic” proteins, wherein the differentially expressed proteins that are used as diagnostic and prognostic indicators can also be used as targets for therapeutic intervention of breast cancer. Also disclosed and described herein are isotope labeled versions of peptides from the proteins.
摘要翻译： 该专利申请公开并描述了在初步诊断后不会引起复发性乳腺癌疾病的原发性乳腺癌细胞和初次诊断后引起复发性乳腺癌疾病的原发性乳腺癌细胞之间发现差异表达的蛋白质。 这些蛋白质可以在乳腺癌患者的各种生物样品的诊断和预后蛋白质测定中单独使用或以特定组合使用，以指示乳腺癌患者的癌症在初步诊断和治疗后将复发的可能性。 确定这些蛋白质的差异表达也可用于指示额外的治疗方法来抵抗复发性乳腺癌的可能性。 可以测定全长完整蛋白质，或者可以将这些蛋白质衍生的肽作为这些蛋白质的报告物进行测定。 这些蛋白质也可以被鉴定为“伴侣诊断”蛋白质，其中用作诊断和预后指标的差异表达的蛋白质也可以用作乳腺癌的治疗干预的靶标。 本文还公开和描述的是来自蛋白质的肽的同位素标记形式。
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4.发明授权Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations 有权通过使用液体组织制剂分析组织病理学处理的生物样品来诊断疾病和病症公开(公告)号：US08609345B2
公开(公告)日：2013-12-17
申请号：US11915581
申请日：2006-05-25
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/57434 , G01N33/6803 , Y02A50/57 , Y02A50/58
摘要： The invention provides methods for diagnosing diseases such as cancer and other conditions using biological samples. Liquid Tissue samples prepared from histopathologically prepared tissue obtained from a subject surprisingly can be used to identify and, optionally, to quantify analytes that are diagnostic of the presence of a disease, condition or syndrome in the subject.
摘要翻译： 本发明提供使用生物样品诊断疾病如癌症和其他病症的方法。 液体从组织病理学制备的组织样品制备的组织样品令人惊奇地可以用于鉴定和任选地定量诊断受试者中疾病，病症或综合征的存在的分析物。
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5.发明授权Liquid tissue preparation from histopathologically processed biological samples, tissues and cells 有权来自组织病理学处理的生物样品，组织和细胞的液体组织制备公开(公告)号：US08455215B2
公开(公告)日：2013-06-04
申请号：US12348868
申请日：2009-01-05
CPC分类号： G01N1/4044 , C12N15/1003 , C12Q1/37 , G01N1/30 , G01N1/44
摘要： The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solubilization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
摘要翻译： 本发明提供了一种将组织病理学处理的生物样品，组织和细胞直接转化成多用途生物分子裂解物的方法。 该方法允许同时提取，分离，溶解和储存包含在组织病理学处理的生物样品中的所有生物分子，从而形成所述样品的代表性文库。 这种多用途生物分子裂解物是可稀释的，可溶的，能够分级，并用于任何数量的后续实验。
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6.发明申请MULTIPLEX LIQUID TISSUE METHOD FOR INCREASED PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES, TISSUES, AND CELLS 有权多组分液体组织方法用于从病理生物学过程生物样品，组织和细胞中增加的保护性覆盖公开(公告)号：US20090136971A1
公开(公告)日：2009-05-28
申请号：US11915582
申请日：2006-05-25
IPC分类号： G01N33/536 , C12P21/06 , G01N33/559 , G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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7.发明授权Biological laser printing for tissue microdissection via indirect photon-biomaterial interactions 有权生物激光打印用于通过间接光子 - 生物材料相互作用进行组织显微切割公开(公告)号：US07381440B2
公开(公告)日：2008-06-03
申请号：US10863833
申请日：2004-06-04
IPC分类号： B05D3/06
CPC分类号： C23C14/048 , A61B18/20 , B01J2219/00527 , B01J2219/00603 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01J2219/00743 , B41M5/38207 , B41M5/385 , B41M5/41 , B41M5/465 , C12N13/00 , C23C14/28 , G01N1/2813 , G01N2001/2886
摘要： A method of laser forward transfer is disclosed. Photo energy is directed through a photon-transparent support and absorbed by an interlayer coated thereon. The energized interlayer causes the transfer of specific regions of a heterogeneous tissue sample coated thereon across a gap and onto a receiving substrate or into a receiving vessel.
摘要翻译： 公开了一种激光正转传输方法。 光能通过光子透明载体引导并被涂覆在其上的层间吸收。 通电中间层使得涂覆在其上的异质组织样品的特定区域跨越间隙转移到接收衬底或接收容器中。
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公开(公告)号：US20150005183A1
公开(公告)日：2015-01-01
申请号：US13932990
申请日：2013-07-01
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N2800/52 , G01N2800/54 , G01N2800/60
摘要： This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells histologicaly defined as early stage (stage 0) breast cancer and primary breast cancer cells histologicaly defined as late stage (stage 3) breast cancer. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the that a breast cancer patient's cancer is in an early, non-aggressive stage or in a late, aggressive stage. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the aggressiveness of late stage breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins. These proteins can also be identified as “companion diagnostic” proteins, wherein the differentially expressed proteins that are used as diagnostic and prognostic indicators can also be used as targets for therapeutic intervention of breast cancer. Also disclosed and described herein are isotope labeled versions of peptides from the proteins.
摘要翻译： 该专利申请公开并描述了被定义为早期阶段（阶段0）乳腺癌的原发肿瘤乳腺癌细胞组织学和定义为晚期（阶段3）乳腺癌的原发性乳腺癌细胞组织学之间差异表达的蛋白质。 这些蛋白质可以在乳腺癌患者的各种生物样品的诊断和预后蛋白测定中单独使用或以特定组合使用，以表明乳腺癌患者的癌症处于早期，非侵袭阶段或晚期侵袭阶段 。 确定这些蛋白质的差异表达也可用于指示其他治疗方法以抵抗晚期乳腺癌的侵袭性。 可以测定全长完整蛋白质，或者可以将这些蛋白质衍生的肽作为这些蛋白质的报告物进行测定。 这些蛋白质也可以被鉴定为“伴侣诊断”蛋白质，其中用作诊断和预后指标的差异表达的蛋白质也可以用作乳腺癌的治疗干预的靶标。 本文还公开和描述的是来自蛋白质的肽的同位素标记形式。
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9.发明授权Multiplex liquid tissue™ method for increased proteomic coverage from histopathologically processed biological samples, tissues and cells 有权用于增加组织病理学处理的生物样品，组织和细胞的蛋白质组覆盖的多重液体组织TM方法公开(公告)号：US08293485B2
公开(公告)日：2012-10-23
申请号：US13048522
申请日：2011-03-15
IPC分类号： G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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10.发明授权Multiplex method for increased proteomic coverage from histopathologically processed biological samples, tissues cells 有权用于增加组织病理学处理的生物样品，组织细胞的蛋白质组覆盖率的多重法公开(公告)号：US07906301B2
公开(公告)日：2011-03-15
申请号：US11915582
申请日：2006-05-25
IPC分类号： G01N33/53
CPC分类号： G01N33/6803 , G01N1/30 , G01N33/6848
摘要： The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample.
摘要翻译： 本发明提供了福尔马林固定组织样品的生物样品的多重分析方法。 本发明提供了从单个组织病理学处理的生物样品同时获得多重多级液体组织制剂的方法，其中每种液体组织制剂的方案对从组织病理学处理的生物学样品中获得的生物分子赋予特殊的生物化学效应 样品和当分析每种制剂时可以提供关于相同组织病理学处理的生物样品的添加剂和补充数据。
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