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    VACCINES AND IMMUNOTHERAPEUTICS USING CODON OPTIMIZED IL-15 AND METHODS FOR USING THE SAME
    1.
    发明申请
    VACCINES AND IMMUNOTHERAPEUTICS USING CODON OPTIMIZED IL-15 AND METHODS FOR USING THE SAME 有权
    使用优化的IL-15的疫苗和免疫球蛋白及其使用方法

    公开(公告)号：US20100003277A1

    公开(公告)日：2010-01-07

    申请号：US12160766

    申请日：2007-01-12

    申请人： David B. Weiner ,  Michele Kutzler

    发明人： David B. Weiner ,  Michele Kutzler

    IPC分类号： A61K39/21 ,  C12N15/11 ,  C12N15/00 ,  A61K39/00 ,  A61K39/245 ,  A61K39/29

    CPC分类号： C07K14/5443 ,  A61K2039/55522 ,  Y02A50/394

    摘要： Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.

    摘要翻译： 公开了编码IL-15或其片段的核酸分子，其以比具有IL-15的天然编码序列的核酸分子更高的水平表达蛋白质。 还公开了具有附加修饰的核酸分子，例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。 包括这种核酸分子的载体，包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。 公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。

    Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
    4.
    发明授权
    Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same 有权
    使用密码子优化的IL-15的疫苗和免疫治疗剂及其使用方法

    公开(公告)号：US08178660B2

    公开(公告)日：2012-05-15

    申请号：US12160766

    申请日：2007-01-12

    申请人： David B. Weiner ,  Michele Kutzler

    发明人： David B. Weiner ,  Michele Kutzler

    IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00

    CPC分类号： C07K14/5443 ,  A61K2039/55522 ,  Y02A50/394

    摘要： Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.

    摘要翻译： 公开了编码IL-15或其片段的核酸分子，其以比具有IL-15的天然编码序列的核酸分子更高的水平表达蛋白质。 还公开了具有附加修饰的核酸分子，例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。 包括这种核酸分子的载体，包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。 公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。

    Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
    5.
    发明授权
    Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same 有权
    编码核酸序列和包含IgE信号肽和/或IL-15的组合物及其使用方法

    公开(公告)号：US08173786B2

    公开(公告)日：2012-05-08

    申请号：US10560650

    申请日：2004-06-14

    申请人： David B. Weiner ,  Michele Kutzler ,  Andrew Y. Choo ,  Joo-Sung Yang ,  Jean D. Boyer

    发明人： David B. Weiner ,  Michele Kutzler ,  Andrew Y. Choo ,  Joo-Sung Yang ,  Jean D. Boyer

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C07K14/5443 ,  A61K2039/53 ,  A61K2039/55527 ,  C07K14/70578 ,  C07K2319/02 ,  Y02A50/394

    摘要： Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.

    摘要翻译： 公开了融合蛋白和编码融合蛋白的核酸分子。 公开了包含与IL-15蛋白质序列连接的非IL-15信号肽和包含与非IgE蛋白序列连接的IgE信号肽的融合蛋白的融合蛋白。 包含这种核酸分子的载体; 公开了包含这种载体的宿主细胞以及编码融合蛋白的重组疫苗和活减毒病原体及其使用方法。 公开了递送IL-15和CD40L（含有或不含免疫原）后的免疫调节作用，用于递送此类蛋白质的各种核酸分子及其组合物以及使用该组合物的方法。