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公开(公告)号：US20120316185A1
公开(公告)日：2012-12-13
申请号：US13576040
申请日：2011-01-31
IPC分类号： A61K31/4439 , C07D471/04 , A61K31/437 , A61P5/04 , A61K31/519 , C07D473/00 , A61K31/52 , C07D401/12 , C07D487/04
CPC分类号： C07D213/82 , C07C233/79 , C07C2601/14 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/54 , C07D231/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/04 , C07D473/00 , C07D491/052
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂式（I）的环己基酰胺衍生物。
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公开(公告)号：US08835444B2
公开(公告)日：2014-09-16
申请号：US13576040
申请日：2011-01-31
IPC分类号： C07C233/79 , C07D213/82 , C07D231/12 , C07D231/38 , C07D249/08 , C07D401/12 , C07D231/16 , C07D473/00 , C07D231/54 , C07D231/14 , C07D405/04 , C07D491/052 , C07D231/20 , C07D231/56 , C07D401/04 , C07D471/04 , C07D401/14
CPC分类号： C07D213/82 , C07C233/79 , C07C2601/14 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/54 , C07D231/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/04 , C07D473/00 , C07D491/052
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂式（I）的环己基酰胺衍生物。
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公开(公告)号：US10112926B2
公开(公告)日：2018-10-30
申请号：US15303879
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D401/14 , C07D413/14 , C07D401/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D213/73 , C07D491/107 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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公开(公告)号：US09862711B2
公开(公告)日：2018-01-09
申请号：US15303890
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Ian Bruce , Andrew James Culshaw , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Ian Bruce , Andrew James Culshaw , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D409/04 , C07D405/14 , C07D403/14 , A61K31/5377 , A61K31/497
CPC分类号： C07D417/04 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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公开(公告)号：US20100035874A1
公开(公告)日：2010-02-11
申请号：US12462417
申请日：2009-08-03
申请人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey Mc Kenna , James Neef , Helen Elizabeth Oakman
发明人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey Mc Kenna , James Neef , Helen Elizabeth Oakman
IPC分类号： A61K31/424 , C07D498/04 , C07D413/14 , A61K31/5377 , A61P43/00
CPC分类号： C07D498/04
摘要： There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的吡唑并[5.1-b]恶唑衍生物。
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公开(公告)号：US10004732B2
公开(公告)日：2018-06-26
申请号：US15303868
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/497 , A61K31/5377 , C07D403/04
CPC分类号： A61K31/497 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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公开(公告)号：US07994203B2
公开(公告)日：2011-08-09
申请号：US12462417
申请日：2009-08-03
申请人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey McKenna , James Neef , Helen Elizabeth Oakman
发明人： Ian Bruce , Andrew James Culshaw , Nicholas James Devereux , François Gessier , Jeffrey McKenna , James Neef , Helen Elizabeth Oakman
IPC分类号： A61K31/4162 , C07D489/04
CPC分类号： C07D498/04
摘要： There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
摘要翻译： 描述了可用作促肾上腺皮质激素释放因子（CRF1）受体拮抗剂的吡唑并[5.1-b]恶唑衍生物。
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公开(公告)号：US08796307B2
公开(公告)日：2014-08-05
申请号：US14076478
申请日：2013-11-11
IPC分类号： A61K31/395
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US20140066478A1
公开(公告)日：2014-03-06
申请号：US14076478
申请日：2013-11-11
IPC分类号： C07D215/26
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways disease.
摘要翻译： 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。
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公开(公告)号：US07745462B2
公开(公告)日：2010-06-29
申请号：US10552023
申请日：2004-04-02
申请人： Robin Alec Fairhurst , David Andrew Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil John Press , Roger John Taylor , Katharine Louise Turner , Simon James Watson
发明人： Robin Alec Fairhurst , David Andrew Sandham , David Beattie , Ian Bruce , Bernard Cuenoud , Reamonn Madden , Neil John Press , Roger John Taylor , Katharine Louise Turner , Simon James Watson
IPC分类号： A61K31/02 , C07D215/38
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula I in free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中-C-Y-，R 1和R 2为G具有本说明书中指出的含义，可用于治疗通过活化2-肾上腺素受体而预防或缓解的病症 。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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