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公开(公告)号：US08871737B2
公开(公告)日：2014-10-28
申请号：US13236435
申请日：2011-09-19
IPC分类号： A61K31/70 , C07H19/04 , C07H19/10 , C07H19/20 , C07H19/06 , A61K31/7072 , C07H19/16 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.
摘要翻译： 本文公开了硫代磷酸酯核苷酸类似物，例如硫代磷酰胺酸酯前药和硫代磷酸酯（包括α-硫代磷酸酯，α-硫代二磷酸酯和α-硫代三磷酸酯），合成硫代磷酸酯核苷酸类似物如硫代磷酰胺酸酯前药和硫代磷酸酯的方法和治疗病毒感染的方法， 例如具有硫代磷酸酯核苷酸类似物的HCV，癌症和/或寄生虫病，例如硫代磷酰胺酸酯前药和硫代磷酸酯。
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公开(公告)号：US20120071434A1
公开(公告)日：2012-03-22
申请号：US13236435
申请日：2011-09-19
IPC分类号： A61K31/7072 , C07H19/20 , A61K31/7076 , A61P31/12 , C12N5/071 , A61P31/22 , A61P31/18 , A61P31/16 , A61P31/20 , C07H19/10 , A61P31/14
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.
摘要翻译： 本文公开了硫代磷酸酯核苷酸类似物，合成硫代磷酸酯核苷酸类似物的方法和用硫代磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20120070411A1
公开(公告)日：2012-03-22
申请号：US13236450
申请日：2011-09-19
申请人： Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
发明人： Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
IPC分类号： A61K38/21 , C07H19/10 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61P31/22 , C12N9/99 , C12N5/071 , A61P31/14 , A61P31/12 , A61P31/20 , C07H19/207 , A61K31/7072
CPC分类号： C07H19/067 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/167 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.
摘要翻译： 本文公开了磷酰胺酸核苷酸类似物，合成氨基磷酸酯核苷酸类似物的方法和用氨基磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。
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公开(公告)号：US20060258613A1
公开(公告)日：2006-11-16
申请号：US11492558
申请日：2006-07-24
IPC分类号： A61K31/7076 , C07H19/00
CPC分类号： C07H19/00 , C07H19/167
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
摘要翻译： 公开了用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染的化合物，组合物和方法。
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公开(公告)号：US20060241064A1
公开(公告)日：2006-10-26
申请号：US11411434
申请日：2006-04-25
IPC分类号： A61K31/7076 , C07H19/00
CPC分类号： A61K31/7076 , C07H19/00 , C07H19/14 , A61K2300/00
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
摘要翻译： 公开了用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染的化合物，组合物和方法。
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公开(公告)号：US20050107312A1
公开(公告)日：2005-05-19
申请号：US10970321
申请日：2004-10-20
CPC分类号： C07H19/14
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
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公开(公告)号：US20070167383A1
公开(公告)日：2007-07-19
申请号：US11559475
申请日：2006-11-14
IPC分类号： A61K31/7076 , C07H19/20 , C07H19/22
CPC分类号： C07H19/14 , A61K31/7076
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
摘要翻译： 公开了用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染的化合物，组合物和方法。
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![Methods for preparing 7-(2'-substituted-beta-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives](/abs-image/US/2005/09/29/US20050215510A1/abs.jpg.150x150.jpg)
8.发明申请Methods for preparing 7-(2'-substituted-beta-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives 失效制备7-（2'-取代-β-D-呋喃核糖基）-4-（NR2R3）-5-（取代的乙炔-1-基） - 吡咯并[2,3-d]嘧啶衍生物的方法公开(公告)号：US20050215510A1
公开(公告)日：2005-09-29
申请号：US10970641
申请日：2004-10-20
IPC分类号： C07H19/14 , C07H19/22 , A61K31/7076
CPC分类号： C07H19/14
摘要： Disclosed are methods and intermediates for the preparation of 7-(2′-R1-substituted-β-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
摘要翻译： 公开了制备7-（2'-R 1 - 取代-β-D-呋喃核糖基）-4-氨基-5-（任选取代的乙炔-1-基） - 吡咯并[2,3-d]嘧啶化合物。 这些化合物可用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染。
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公开(公告)号：US20060111311A1
公开(公告)日：2006-05-25
申请号：US11280984
申请日：2005-11-15
IPC分类号： A61K31/7076 , C07H19/22
CPC分类号： A61K31/7076 , A61K38/21 , C07H19/14 , C07H19/22 , A61K2300/00
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
摘要翻译： 公开了用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染的化合物，组合物和方法。
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公开(公告)号：US20050215511A1
公开(公告)日：2005-09-29
申请号：US10971477
申请日：2004-10-21
IPC分类号： C07H19/14 , A61K31/7076 , C07H19/22
CPC分类号： C07H19/14 , A61K31/7076
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
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