公开(公告)号：US5057038A

公开(公告)日：1991-10-15

申请号：US587137

申请日：1990-09-24

Applicant: David C. Bowen ,  Philip J. Dambach ,  Joseph W. Nelligan, Jr. ,  Irvin R. Triner

Inventor： David C. Bowen ,  Philip J. Dambach ,  Joseph W. Nelligan, Jr. ,  Irvin R. Triner

IPC: H01R9/03 ,  H01R13/648 ,  H01R13/658 ,  H01R13/6585

CPC classification number: H01R13/6585

Abstract: A shielded electrical connector is formed by the mating of upper and lower housing covers and is used with twisted pair cables, each of which includes a pair of signal wires and a drain wire enclosed within an outer insulation. Each pair of terminated signal wires is disposed in a contact module which is positioned in one of a plurality of shielded compartments formed between adjacent separating walls extending from the outer housing covers when the covers are mated with each other. Each of the separating walls has a positioning slot into which a positioning rib on the contact modules may be disposed in order to properly position and retain the contact module in one of the shielded compartments. A ferrule assembly is crimped about the end of the insulation of each of the cables and is coupled to the drain wire of the twisted pair cable. A bus bar coupled to ground terminals disposed in contact modules in the connector is positioned within the connector housing so as to be in contact with each of the ferrule assemblies and includes resilient fingers that engage one of the housing covers to thereby couple the drain wires to the ground terminals and the housing covers. A pull tab may be secured to the rear of the connector housing to aid in extracting the connector from an other connector.

公开(公告)号：US4907978A

公开(公告)日：1990-03-13

申请号：US266106

申请日：1988-11-02

Applicant: David C. Bowen

Inventor： David C. Bowen

IPC: H01R12/50 ,  H05K3/30

CPC classification number: H05K3/308 ,  H01R12/716 ,  H05K2201/10189 ,  H05K2201/10484 ,  H05K2201/10878 ,  Y10T29/49139

Abstract: A connector is provided for mounting on a circuit board. The connector includes a body member and rows of first and second electrical contact pins coupled to the body member. The first contact pins are configured to extend downwardly below a bottom wall of the body member so that they align with the bottom wall to define an acute included angle therebetween. The second contact pins are configured to extend downwardly below the bottom wall in splayed relation to the first electrical contact pins and are aligned with the bottom wall to define an obtuse included angle therebetween. The first and second contact pins are made of spring material and cooperate to define a spring clip for yieldably drawing the bottom wall of the body member into seating engagement with the circuit board upon insertion of the first and second electrical contact pins into a pair of pin-receiving apertures formed in the circuit board.

Abstract translation: 提供一个用于安装在电路板上的连接器。 连接器包括本体构件和联接到主体构件的第一和第二电接触销的行。 第一接触销构造成在主体构件的底壁下方向下延伸，使得它们与底壁对准以在其间限定锐角。 第二接触销构造成以与第一电接触销相对的方式向下延伸到底壁下方并且与底壁对准以在其间限定钝角。 第一和第二接触销由弹簧材料制成并且协作以限定弹簧夹，用于在将第一和第二电触针插入一对销时可弹性地拉动主体部件的底壁与电路板就座接合 - 形成在电路板中的接收孔。

公开(公告)号：US06852838B2

公开(公告)日：2005-02-08

申请号：US10016283

申请日：2001-11-30

Applicant: David M. Valenzuela ,  David J. Glass ,  David C. Bowen ,  George D. Yancopoulos

Inventor： David M. Valenzuela ,  David J. Glass ,  David C. Bowen ,  George D. Yancopoulos

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P21/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/78 ,  C07K14/81 ,  C07K16/38 ,  C07K16/40 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  C12R1/19 ,  C12R1/84 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

CPC classification number: C07K16/38 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/70567 ,  C07K14/70571 ,  C07K14/71 ,  C07K14/78 ,  C07K14/811

Abstract: The present invention provides for a gene, designated as musk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.

Abstract translation: 本发明提供了一种称为麝香的基因，其编码在去神经支配的肌肉中以高水平表达的新型酪氨酸激酶受体。 本发明还提供了激活MuSK受体的分离的多肽。 本发明进一步提供功能上等同于MuSK激活多肽的多肽。 本发明还提供可用于检测和/或测量结合麝香基因产物的配体的测定系统。 本发明还提供了基于激活MuSK的分子的诊断和治疗方法。

公开(公告)号：US06284539B1

公开(公告)日：2001-09-04

申请号：US09169309

申请日：1998-10-09

Applicant: David C. Bowen ,  Karl K. Johe

Inventor： David C. Bowen ,  Karl K. Johe

IPC: C12N1563

CPC classification number: C12N5/0619 ,  A61K35/12 ,  C12N2501/01 ,  C12N2501/60 ,  C12N2510/00

Abstract: The present invention describes a novel method to direct a particular set of fate choice decisions by multipotential precursor cells from the central nervous system. Specifically we show that introducing the gene coding for the nuclear receptor, Nurr1, into central nervous system (CNS) stem cells causes cells to adopt a dopaminergic cell fate. One use of this technology would be to prepare in vitro neural populations enriched in dopaminergic cells for transplantation in Parkinson's Disease or other neurological disorders. Furthermore, the finding that Nurr1 expression induces a dopaminergic phenotype suggests that introducing this gene into the brains of patients in which dopaminergic cells are degenerating or have been injured may promote the functional recovery of these neurons and thus the clinical recovery of the patient. Finally, the technology described in this application could be incorporated into a program of drug screening or gene discovery.

Abstract translation: 本发明描述了一种通过来自中枢神经系统的多潜能前体细胞引导特定命运选择决定的新方法。 具体来说，我们表明，将编码核受体Nurr1的基因导入中枢神经系统（CNS）干细胞导致细胞采用多巴胺能细胞命运。 该技术的一个用途将是制备富含多巴胺能细胞的体外神经群体用于帕金森病或其他神经障碍的移植。 此外，Nurr1表达诱导多巴胺能表型的发现表明，将该基因导入多巴胺能细胞退化或受损的患者的脑中可能促进这些神经元的功能恢复，从而促进患者的临床康复。 最后，本申请中描述的技术可以并入药物筛选或基因发现程序中。

公开(公告)号：US5465479A

公开(公告)日：1995-11-14

申请号：US223917

申请日：1994-04-06

Applicant: David C. Bowen ,  Frank A. Harwath ,  Irvin R. Triner

Inventor： David C. Bowen ,  Frank A. Harwath ,  Irvin R. Triner

IPC: H01R43/01

CPC classification number: H01R43/01 ,  Y10T29/53217 ,  Y10T29/53265

Abstract: A locating fixture system is provided for aligning a multi-conductor flat electrical cable with an elongated electrical connector having a plurality of terminals for termination to the conductors of the cable. A fixture base defines a cable platform for supporting the multi-conductor flat electrical cable. A receptacle in the base receives the elongated electrical connector generally transversely of the cable, with the terminals projecting above the cable platform for termination to the conductors of the cable. A locating pin is provided on the base within the receptacle for insertion into a locating hole in the connector intermediate opposite ends of the connector for properly locating the connector transversely of the cable.

Abstract translation: 提供了一种定位夹具系统，用于使多导体扁平电缆与具有用于终止于电缆的导体的多个端子的细长电连接器对准。 夹具基座限定用于支撑多导体扁平电缆的电缆平台。 基座中的一个插座接收大体横向于电缆的细长电连接器，端子突出在电缆平台的上方，用于端接到电缆的导体。 定位销设置在插座内的基座上，用于插入连接器中的连接器中的定位孔中间连接器的相对端，用于将连接器横向放置在电缆上。

公开(公告)号：US5542854A

公开(公告)日：1996-08-06

申请号：US373816

申请日：1995-01-17

Applicant: David C. Bowen

Inventor： David C. Bowen

IPC: H01R13/629 ,  H01R12/70 ,  H01R13/62 ,  H05K20060101 ,  H05K1/11

CPC classification number: H01R12/7005

Abstract: A connector for an edge card includes a card slot having a plurality of contact terminals disposed in a predetermined spacing. The connector also includes two latch/eject members pivotally mounted to the connector at the ends thereof in alignment with the connector card slot. The latch/eject members include an alignment surface positioned opposite the end edges of an edge card during insertion and the alignment surfaces are further positioned on the latch/eject members above an ejection surface such that the contact area between the connector housing terminals and the circuit card lies between the ejection and alignment surfaces. The alignment surface is a surface of potential revolution.

Abstract translation: 用于边缘卡的连接器包括具有以预定间隔布置的多个接触端子的卡槽。 连接器还包括两个闩锁/弹出构件，其枢转地安装在连接器的端部处，与连接器卡槽对齐。 闩锁/弹出构件包括在插入期间与边缘卡片的端部边缘相对定位的对准表面，并且对准表面进一步定位在喷射表面上方的闩锁/弹出构件上，使得连接器壳体端子与电路之间的接触区域 卡位于喷射和对准表面之间。 对准表面是潜在旋转的表面。

公开(公告)号：US5383796A

公开(公告)日：1995-01-24

申请号：US158136

申请日：1993-11-24

Applicant: David C. Bowen ,  Jerry A. Long

Inventor： David C. Bowen ,  Jerry A. Long

IPC: H01R13/595

CPC classification number: H01R13/595

Abstract: An electrical connector includes a shell having a cavity and a cable-receiving opening adapted to receive an electrical cable. The opening defines an axis, and a pair of screw posts are located in the cavity spaced on opposite sides of the axis such that the cable can be positioned therebetween. A cable clamp member includes a center section adapted to embrace one side of the cable, and a pair of wing sections extending from the center section and having screw-receiving holes alignable with the screw posts. The clamp member includes flanges projecting from the wing sections, with the flanges having slots for embracing ribs on the shell to preposition the cable clamp member over the cable with the screw-receiving holes aligned with the screw posts.

Abstract translation: 电连接器包括具有空腔的外壳和适于接收电缆的电缆接收开口。 开口限定轴线，并且一对螺钉柱位于在轴的相对侧上间隔开的空腔中，使得电缆可以位于其间。 电缆夹构件包括适于包围电缆的一侧的中心部分和从中心部分延伸并具有可与螺钉柱对准的螺钉接收孔的一对翼部。 夹紧构件包括从翼部突出的凸缘，凸缘具有用于包围壳体上的肋的槽，用于将电缆夹构件介于电缆上，螺钉容纳孔与螺钉柱对准。

公开(公告)号：US5186643A

公开(公告)日：1993-02-16

申请号：US762698

申请日：1991-09-19

Applicant: Patrick D. Bakke ,  David C. Bowen

Inventor： Patrick D. Bakke ,  David C. Bowen

IPC: H01R12/50 ,  H01R12/72 ,  H01R12/73 ,  H01R12/83

CPC classification number: H01R12/83 ,  H01R12/721 ,  H01R12/737

Abstract: An edge connector is disclosed for a printed circuit board having a mating edge and a plurality of contact pads adjacent the edge. The connector includes an elongated insulating housing having a plurality of contacts mounted on the housing along the length thereof for engaging the printed circuit board contact pads when the printed circuit board is inserted into the housing at a first angular position and subsequently pivoted to a second angular position. The contacts exert an opposing force against the printed circuit board when pivoted to the second angular position. A latching device has a latching section for engaging the printed circuit board. The latching device is rotatably mounted on the housing for rotation from a first position to a second position in response to pivoting the printed circuit board from its first angular position to its second angular position. The latching device is linearly moveable from its second position to a third locking position under the influence of the opposing force of the spring contacts. Complementary interengaging latching surfaces are provided between the latching device and the housing for automatically locking the printed circuit board to the housing when the latching device moves to its third locking position.

Abstract translation: 公开了一种具有配合边缘和邻近边缘的多个接触垫的印刷电路板的边缘连接器。 连接器包括细长绝缘壳体，其具有沿着其长度安装在壳体上的多个触点，用于当印刷电路板在第一角度位置处插入到壳体中并且随后枢转到第二角度时接合印刷电路板接触垫 位置。 当枢转到第二角度位置时，触点对印刷电路板施加相反的力。 闩锁装置具有用于接合印刷电路板的闩锁部分。 响应于将印刷电路板从其第一角位置枢转到其第二角位置，闩锁装置可旋转地安装在壳体上用于从第一位置转动到第二位置。 闩锁装置在弹簧触头的相反力的影响下可从其第二位置线性移动到第三锁定位置。 当锁定装置移动到其第三锁定位置时，在闩锁装置和壳体之间提供互补的相互接合的锁定表面，用于将印刷电路板自动地锁定到壳体。

公开(公告)号：US5814478A

公开(公告)日：1998-09-29

申请号：US644271

申请日：1996-05-10

Applicant: David M. Valenzuela ,  David J. Glass ,  David C. Bowen ,  George D. Yancopoulos

Inventor： David M. Valenzuela ,  David J. Glass ,  David C. Bowen ,  George D. Yancopoulos

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K48/00 ,  A61P21/00 ,  C07K14/705 ,  C07K14/78 ,  C07K14/81 ,  C07K16/38 ,  C07K16/40 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  C12R1/19 ,  C12R1/84 ,  G01N33/53 ,  G01N33/566 ,  C12P21/06

CPC classification number: C07K14/78 ,  C07K14/70567 ,  C07K14/70571 ,  C07K14/811 ,  C07K16/38 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention provides for a gene, designated as musk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated and purified polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.

Abstract translation: 本发明提供了一种称为麝香的基因，其编码在去神经支配的肌肉中以高水平表达的新型酪氨酸激酶受体。 本发明还提供活化MuSK受体的分离和纯化的多肽。 本发明进一步提供功能上等同于MuSK激活多肽的多肽。 本发明还提供可用于检测和/或测量结合麝香基因产物的配体的测定系统。 本发明还提供了基于激活MuSK的分子的诊断和治疗方法。

公开(公告)号：US5409396A

公开(公告)日：1995-04-25

申请号：US201286

申请日：1994-02-22

Applicant: David C. Bowen ,  Jerry A. Long

Inventor： David C. Bowen ,  Jerry A. Long

IPC: H01R12/67 ,  H01R12/70 ,  H01R13/58

CPC classification number: H01R23/661 ,  H01R12/675

Abstract: A cable strain relief system is provided for an electrical connector assembly which terminates a multi-conductor ribbon cable. A pair of interengageable elongated strain relief members clamp the ribbon cable therebetween. A flexible latch arm with a latch hook is provided on at least one of the strain relief members. A latch passage and a latch shoulder is provided on at least the other of the strain relief members for receiving the latch arm and latchingly engaging the latch hook of the one strain relief member. A rigid alignment element is provided on at least one of the strain relief members, and an alignment opening is provided on at least the other of the strain relief members for receiving the rigid alignment element. The latch passage is sized to receive the latch arm and latch hook freely thereinto with the pair of strain relief members offset relative to each other, and with the latch arm in an initial unflexed condition. The rigid alignment element is adapted to be inserted into the alignment opening after the latch arm has been inserted into the latch passage to draw the offset strain relief members laterally into alignment and to guide the members into fully engaged and latched condition with the latch arm flexed and the latch hook engaged with the latch shoulder.

Abstract translation: 为连接多导体带状电缆的电连接器组件提供电缆应变消除系统。 一对相互接合的细长应变消除部件将带状电缆夹在其间。 在至少一个应变消除构件上设置有具有闩锁钩的柔性闩锁臂。 至少另一个应变消除构件上设置有闩锁通道和闩锁肩部，用于接收闩锁臂并闩锁地接合一个应变消除构件的闩锁钩。 在至少一个应变消除构件上设置有刚性对准元件，并且在至少另一个应变消除构件上设置对准开口以接收刚性对准元件。 闩锁通道的尺寸被设计成能够将锁定臂和锁钩自由地接纳在其中，而一对应变消除构件相对于彼此偏移，并且锁定臂处于初始未弯曲状态。 刚性对准元件适于在闩锁臂已经插入闩锁通道中之后插入到对准开口中，以将偏移应变消除元件横向地对准并且在闩锁臂弯曲时将构件引导到完全接合和锁定状态 并且闩锁钩与闩锁肩部接合。