-
公开(公告)号:US5254698A
公开(公告)日:1993-10-19
申请号:US654607
申请日:1991-02-12
申请人: David Coates , Simon Greenfield , Graham Smith , Volker Reiffenrath , Joachim Krause , Herbert Plach
发明人: David Coates , Simon Greenfield , Graham Smith , Volker Reiffenrath , Joachim Krause , Herbert Plach
IPC分类号: G02F1/13 , C07D319/06 , C09K19/34 , C09K19/42 , C07C319/06
CPC分类号: C09K19/3402 , C07D319/06 , C09K2019/3422
摘要: Phenyldioxanes of the formula I ##STR1## wherein R.sup.1 is an alkyl or alkenyl residue each with up to 16 C atoms, wherein one or two non-adjacent CH.sub.2 groups of these residues may be replaced by --CO--O-- or --O--CO--,Q.sup.1 and Q.sup.2 are each independently ##STR2## L.sup.1 and L.sup.2 are each independently F or H, and Y is Cl, F, CN, CF.sub.3, OCF.sub.3 or OCF.sub.2 H,m and n is 0 or 1,are suitable as components of liquid crystal media.
摘要翻译: PCT No.PCT / EP90 / 02132 Sec。 371日期1991年2月12日 102(e)日期1991年2月12日PCT提交1990年12月8日PCT公布。 出版物WO91 / 09026 日期:1991年6月27日。式I的苯基二恶烷其中R 1是具有至多16个C原子的烷基或链烯基,其中这些残基的一个或两个不相邻的CH 2基团可被-CO -O-或-O-CO-,Q1和Q2各自独立地为1,L 1和L 2各自独立地为F或H,Y为Cl,F,CN,CF 3,OCF 3或OCF 2 H, m和n为0或1,适合作为液晶介质的组分。
-
公开(公告)号:US5496499A
公开(公告)日:1996-03-05
申请号:US180413
申请日:1994-01-12
申请人: Eike Poetsch , Volker Meyer , Klaus P. Stahl , Volker Reiffenrath , Ulrich Finkenzeller , Ekkehard Bartmann , Reinhard Hittich , David Coates , Simon Greenfield , Graham Smith , Hans A. Kurmeier , Dieter Dorsch
发明人: Eike Poetsch , Volker Meyer , Klaus P. Stahl , Volker Reiffenrath , Ulrich Finkenzeller , Ekkehard Bartmann , Reinhard Hittich , David Coates , Simon Greenfield , Graham Smith , Hans A. Kurmeier , Dieter Dorsch
IPC分类号: G02F1/13 , C07C22/08 , C07C25/18 , C07C25/24 , C07C43/174 , C07C43/225 , C07C205/12 , C07C255/50 , C07C323/09 , C07C323/18 , C07C323/62 , C07C331/28 , C09K19/14 , C09K19/30 , C09K19/12
CPC分类号: C07C22/08 , C07C25/18 , C07C255/50 , C07C43/225 , C09K19/14 , C09K19/3028 , C07C2101/14
摘要: Biphenylylethanes of the formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 is X and the other radical R.sup.1 or R.sup.2 is R--Y-- whereX is H, halogen, --CF.sub.3, --OCHF.sub.2, --OCF.sub.3, --CN, --NCS or --NO.sub.2,R is alkyl, fluoroalkyl, alkenyl or oxaalkyl andY is O, S, --CO--O--, --O--CO--, --O--CO--O--, a single bond or--in the case where m=1--alternatively trans-1,4-cyclohexylene or ##STR2## m is 1 or 2, Ph is in each case identical or different radicals selected from the group comprising 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene and 3,5-difluoro-1,4-phenylene,L.sup.3 and L.sup.4 are each H, or one of these radicals is alternatively F,L.sup.1, L.sup.2and L.sup.5 are each H or F, with the proviso that in the case where X=CN or R.sup.1 =--NCS, Y is trans-1,4-cyclohexylene or ##STR3## and/or m=2 and/or one of the radicals L.sup.1, L.sup.2 and L.sup.3 is fluorine and/or Ph--CN is 2-fluoro-4-cyanophenyl or 3,5-difluoro-4-cyanophenyl,are suitable as components of liquid-crystalline phases.
摘要翻译: 其中基团R 1和R 2中的一个为X并且另一个基团R 1或R 2为RY-,其中X为H,卤素,-CF 3,-OCHF 2,-OCF 3,-CN, - C 1 -C 6烷基的双苯并噻吩, NCS或-NO 2,R是烷基,氟烷基,烯基或氧杂烷基,Y是O,S,-CO-O-,-O-CO-,-O-CO-O-,单键或 - m = 1-替代反-1,4-亚环己基或m为1或2,Ph各自为相同或不同的基团,选自1,4-亚苯基,2-氟-1,4-亚苯基, 亚苯基,3-氟-1,4-亚苯基和3,5-二氟-1,4-亚苯基,L3和L4各自为H,或者这些基团中的一个为F,L 1,L 2和L 5各自为H或F 条件是在X = CN或R1 = -NCS的情况下,Y为反式-1,4-亚环己基或/或m = 2,和/或基团L1,L2和L3之一为 氟和/或Ph-CN是2-氟-4-氰基苯基或3,5-二氟-4-氰基苯基,适合作为液晶相的组分。
-
公开(公告)号:US5958290A
公开(公告)日:1999-09-28
申请号:US392682
申请日:1995-02-23
申请人: David Coates , Shirley Marden , Graham Smith , Ulrich Finkenzeller , Volker Reiffenrath , Reinhard Hittich , Stefan Wilhelm
发明人: David Coates , Shirley Marden , Graham Smith , Ulrich Finkenzeller , Volker Reiffenrath , Reinhard Hittich , Stefan Wilhelm
IPC分类号: C09K19/12 , C09K19/30 , C09K19/42 , C09K19/44 , C09K19/54 , G02F1/1334 , C09K19/52 , G02F1/133
CPC分类号: G02F1/1334 , C09K19/12 , C09K19/3003 , C09K19/3028 , C09K19/42 , C09K19/44 , C09K19/544
摘要: The invention relates to an electrooptical liquid crystal systemwhich contains a dielectrically positive liquid crystal mixture and a further optically transparent medium between 2 electrodes which are optionally applied to substrate sheets,whose liquid crystal molecules in the switched-off state have an irregular orientation,in which one of the refractive indices of the liquid crystal mixture essentially agrees with the refractive index of the matrix n.sub.M and/or in which the quotient of the mass of the liquid crystal mixture and of the mass of the optically transparent medium is 1.5 or more and,which, independently of the polarization of the incident light, has a reduced transmission in one of the two switch states compared to the other state andwhose liquid crystal mixture contains one or more compounds of the formula I ##STR1## in which Q.sup.1 is ##STR2## are independently of one another trans-1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene and one of A.sup.1 and, if present, A.sup.2, is also pyridine-2,5-diyl, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl or naphthalene-2,6-diyl,Z.sup.1 and Z.sup.2 are independently of one another a single bond, --CH.sub.2 CH.sub.2 --, --COO--, --OCO--, --C.tbd.C--, --CH.sub.2 O-- or any desired combinations of these bridge groups,Y and X are independently of one another H or F, and one of X and Y is also Cl,W is --CN, --Cl, --F, --CF.sub.3, --OCF.sub.3, --OCHF.sub.2, --NCS or R.sup.2R.sup.1 and R.sup.2 independently of one another are alkyl having 1-12 C atoms, in which one or 2 non-adjacent CH.sub.2 groups can also be replaced by --O-- or --HC.dbd.CH--, andm is 0, 1 or 2.
摘要翻译: 本发明涉及一种电光学液晶体系,其包含介于两个电极之间的介电正极液晶混合物和另外的光学透明介质,所述两个电极任选地施加到基板上,所述基板在关闭状态下的液晶分子具有不规则取向, 液晶混合物的折射率之一基本上与基体nM的折射率一致,和/或其中液晶混合物的质量和光学透明介质的质量的商为1.5以上, ,其独立于入射光的偏振,与其他状态相比,在两种开关状态之一中具有降低的透射率,并且其液晶混合物含有一种或多种式I的化合物,其中Q1独立地为一个 另一个反式-1,4-亚环己基,1,4-亚苯基,2-氟-1,4-亚苯基,3-氟-1,4-亚苯基和A1中的一个,如果 t,A2也是吡啶-2,5-二基,嘧啶-2,5-二基,1,3-二恶烷-2,5-二基,四氢吡喃-2,5-二基或萘-2,6-二基, Z 1和Z 2彼此独立地是单键,-CH 2 CH 2 - , - COO - , - OCO-, - C 3BOND C - , - CH 2 O-或这些桥基的任何所需组合,Y和X彼此独立地 H或F,X和Y中的一个也是Cl,W是-CN,-Cl,-F,-CF 3,-OCF 3,-OCHF 2,-NCS或R 2,R 1和R 2彼此独立地是具有1- 12个C原子,其中一个或两个不相邻的CH2基团也可以被-O-或-HC = CH-取代,m是0,1或2。
-
公开(公告)号:US5344587A
公开(公告)日:1994-09-06
申请号:US687852
申请日:1991-06-03
申请人: David Coates , Shirley Marden , Graham Smith , Ulrich Finkenzeller , Volker Reiffenrath , Reinhard Hittich , Stefan Wilhelm
发明人: David Coates , Shirley Marden , Graham Smith , Ulrich Finkenzeller , Volker Reiffenrath , Reinhard Hittich , Stefan Wilhelm
IPC分类号: G02F1/13 , C09K19/00 , C09K19/12 , C09K19/30 , C09K19/42 , C09K19/44 , C09K19/54 , G02F1/133 , C09K19/52
CPC分类号: C09K19/12 , C09K19/3003 , C09K19/3028 , C09K19/42 , C09K19/44 , C09K19/544
摘要: The invention relates to an electrooptical liquid crystal systemwhich contains a dielectrically positive liquid crystal mixture and a further optically transparent medium between 2 electrodes which are optionally applied to substrate sheets,whose liquid crystal molecules in the switched-off state have an irregular orientation,in which one of the refractive indices of the liquid crystal mixture essentially agrees with the refractive index of the matrix n.sub.M and/or in which the quotient of the mass of the liquid crystal mixture and of the mass of the optically transparent medium is 1.5 or more and,which, independently of the polarization of the incident light, has a reduced transmission in one of the two switch states compared to the other state andwhose liquid crystal mixture contains one or more compounds of the formula I ##STR1## in which Q.sup.1 is ##STR2## are independently of one another trans-1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-l,4-phenylene, 3-fluoro-1,4-phenylene and one of A.sup.1 and, if present, A.sup.2, is also pyridine-2,5-diyl, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl or naphthalene-2,6-diyl,Z.sup.1 and Z.sup.2 are independently of one another a single bond, --CH.sub.2 CH.sub.2 --, --COO--, --OCO--, --C--C--, --CH.sub.2 O-- or any desired combinations of these bridge groups,Y and X are independently of one another H or F, and one of X and Y is also Cl,W is --CN, --Cl, --F, --CF.sub.3, --OCF.sub.3, --OCHF.sub.2, --NCS or R.sup.2R.sup.1 and R.sup.2 independently of one another are alkyl having 1-12 C atoms, in which one or 2 non-adjacent CH.sub.2 groups can also be replaced by --O-- or --HC.dbd.CH--, andm is 0, 1 or 2.
摘要翻译: 本发明涉及一种电光学液晶体系,其包含介于两个电极之间的介电正极液晶混合物和另外的光学透明介质,所述两个电极任选地施加到基板上,所述基板在关闭状态下的液晶分子具有不规则取向, 液晶混合物的折射率之一基本上与基体nM的折射率一致,和/或其中液晶混合物的质量和光学透明介质的质量的商为1.5以上, ,其独立于入射光的偏振,与其他状态相比,在两种开关状态之一中具有减小的透射率,并且其液晶混合物含有一种或多种式I的化合物I I,其中Q1是 相对于反式-1,4-亚环己基,1,4-亚苯基,2-氟-1,4-亚苯基,3-氟-1,4-亚苯基, A1中的一个,如果存在,A2也是吡啶-2,5-二基,嘧啶-2,5-二基,1,3-二恶烷-2,5-二基,四氢吡喃-2,5-二基或萘 -2,6-二基,Z1和Z2彼此独立地为单键,-CH2CH2-,-COO-,-OCO-,-CC-,-CH2O-或这些桥基的任何所需组合,Y和X 独立地为H或F,X和Y中的一个也是Cl,W是-CN,-Cl,-F,-CF 3,-OCF 3,-OCHF 2,-NCS或R 2 R 1和R 2彼此独立地 是具有1-12个C原子的烷基,其中一个或两个不相邻的CH 2基团也可被-O-或-HC = CH-取代,m是0,1或2。
-
公开(公告)号:US5637257A
公开(公告)日:1997-06-10
申请号:US461741
申请日:1995-06-05
申请人: David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
发明人: David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
IPC分类号: C07C17/26 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/30 , C07C19/08
CPC分类号: C07C17/263 , C07C17/2632 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C07C2101/14
摘要: Disclosed are compounds of formula I ##STR1## wherein R is C.sub.1-12 -alkyl or halogenoalkyl wherein one or two non-adjacent CH.sub.2 groups are optionally replaced by --O--,A is ##STR2## Q is a bivalent radical of formula (2), and L.sup.0, L.sup.1 and L.sup.2 are each independently H or F, with the proviso that at least one of L.sup.0, L.sup.1 and L.sup.2 present in the molecule denotes F.
摘要翻译: 公开了式I的化合物其中R是C 1-12 - 烷基或卤代烷基,其中一个或两个不相邻的CH 2基团任选被-O-取代,(2)Q是二价基团 式(2)和L0,L1和L2各自独立地为H或F,条件是分子中存在的L 0,L 1和L 2中的至少一个表示F.
-
公开(公告)号:US5482653A
公开(公告)日:1996-01-09
申请号:US902801
申请日:1992-06-24
申请人: David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
发明人: David Coates , Ian C. Sage , Simon Greenfield , Graham Smith , David W. Baxter
IPC分类号: C07C17/26 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/30 , C07C19/08
CPC分类号: C07C17/263 , C07C17/2632 , C07C17/354 , C07C25/18 , C07C69/017 , C07C69/63 , C09K19/12 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C07C2101/14
摘要: The invention relates to fluoro-chloro-benzene derivatives of the formula I ##STR1## wherein R denotes an alkyl or halogenoalkyl residue of up to 12 C atoms wherein one or two non-adjacent CH.sub.2 groups may also be replaced by -0- and/or -HC=CH-,the radical A is a ring of the formula (1) or (2): ##STR2## Q is a bivalent radical of the formula (1) or (2) or a single bond or--if radical A denotes trans-1,4-cyclohexylene--is also a bivalent radical of the formulae (3), (4) or (5): ##STR3## and L.degree., L.sup.1 and L.sup.2 are each independently H or F, with the proviso that at least one of L.degree., L.sup.1 and L.sup.2 present in the molecule denotes F.
摘要翻译: 本发明涉及式I的氟 - 氯 - 苯衍生物,其中R表示高达12个C原子的烷基或卤代烷基残基,其中一个或两个不相邻的CH2基团也可以被-O-取代, /或-HC = CH-,基团A是式(1)或(2)的环:Q是式(1)或(2)的二价基团或单键或-if 基团A表示反式-1,4-亚环己基 - 也是式(3),(4)或(5)的二价基团:(3) L DEG,L1和L2各自独立地为H或F,条件是分子中存在的L DEG,L1和L2中的至少一个表示F.
-
公开(公告)号:US08963602B2
公开(公告)日:2015-02-24
申请号:US11575696
申请日:2005-09-21
申请人: David Robert Bolton , Graham Smith
发明人: David Robert Bolton , Graham Smith
CPC分类号: H03B19/00
摘要: A pulse generator is disclosed. The pulse generator can include an ac source for providing an ac signal. A pulsed switch can be connected to an ac output of the ac source that is adapted or configured to generate a pulsed output from the ac signal and a non-linear frequency multiplier adapted or configured to shorten the pulses of the pulsed output. The pulsed switch can include a mixer.
摘要翻译: 公开了一种脉冲发生器。 脉冲发生器可以包括用于提供交流信号的交流电源。 脉冲开关可以连接到交流电源的交流输出,适配或配置为产生来自交流信号的脉冲输出,以及适用于或配置为缩短脉冲输出脉冲的非线性倍频器。 脉冲开关可以包括混合器。
-
公开(公告)号:US20130129447A1
公开(公告)日:2013-05-23
申请号:US13743545
申请日:2013-01-17
CPC分类号: F16B23/0007 , A61B17/8615 , A61B17/862 , A61B17/888 , A61B17/8891 , B21K1/56 , B25B15/005 , B25B23/101 , F16B23/003 , F16B23/0061 , Y10T29/49826
摘要: According to example configurations, a modified screw head includes one or more slots or grooved channels. A screwdriver device includes a tip that can be inserted into a cavity in the head of the screw to torque the modified screw into an object. The screwdriver device includes a sleeve. The sleeve slides along a shaft of the screwdriver. The sleeve includes inward protruding posts (e.g., pins, fingers, etc.). Sliding of the sleeve over the screw's head requires that inward protruding posts in the sleeve be aligned with the grooves on the sidewall of the screw's head. Subsequent to aligning and sliding the sleeve into the grooved channels of the screw's head, the user twists the sleeve to secure the screw head to the screwdriver's tip. The sleeve can be spring-loaded to pull the head of the screw toward a handle end of the screwdriver after a user releases the sleeve.
摘要翻译: 根据示例性构造,改进的螺钉头包括一个或多个槽或槽形通道。 螺丝刀装置包括能够插入到螺钉的头部中的空腔中的尖端,以将改进的螺钉扭转成物体。 螺丝刀装置包括套筒。 套筒沿螺丝刀的轴滑动。 套筒包括向内突出的柱(例如,针,手指等)。 将套筒滑过螺钉头部需要使套筒内的向内突出的柱与螺钉头部侧壁上的凹槽对准。 在将套筒对准和滑动到螺钉头部的槽形通道中之后,用户扭转套筒以将螺钉头固定到螺丝刀的尖端。 在使用者释放套筒之后,套筒可以被弹簧加载以将螺钉的头部拉向螺丝刀的手柄端。
-
公开(公告)号:US20130116206A1
公开(公告)日:2013-05-09
申请号:US13518000
申请日:2010-12-22
申请人: Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
发明人: Federica Pisaneschi , Alan Spivey , Graham Smith , Eric Aboagye
IPC分类号: C07D215/54 , C07H19/056 , A61K31/706 , A61K31/4706 , A61K31/4709 , C07D401/12 , A61K45/06
CPC分类号: C07D215/54 , A61K31/4706 , A61K31/4709 , A61K31/706 , A61K45/06 , C07D401/12 , C07H19/056
摘要: There is provided compounds of formula (I), wherein R1, R2, X1, X2, and X3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as positron emission tomography (PET) imaging agents, useful in the treatment of diseases in which inhibition of epidermal growth factor receptor tyrosine kinase activity or the inhibition of HER2 activity is desired and/or required, and useful in the treatment of cancer.
摘要翻译: 提供式(I)化合物,其中R1,R2,X1,X2和X3具有说明书中给出的含义及其药学上可接受的盐,该化合物可用作正电子发射断层摄影(PET)成像剂,有用 在治疗其中期望和/或需要抑制表皮生长因子受体酪氨酸激酶活性或抑制HER2活性的疾病,并且可用于治疗癌症。
-
公开(公告)号:US20130066371A1
公开(公告)日:2013-03-14
申请号:US13606886
申请日:2012-09-07
IPC分类号: A61B17/04
CPC分类号: A61B17/8872 , A61B17/0401 , A61B17/0485 , A61B17/0487 , A61B17/1684 , A61B17/1697 , A61B17/1778 , A61B17/82 , A61B17/864 , A61B17/8897 , A61B2017/00407 , A61B2017/0404 , A61B2017/0488 , A61B2017/0496 , A61B2017/06176 , A61F2/4081 , A61F2/4601
摘要: A surgical assembly includes a first guidewire and a second guidewire, in which each of the first guidewire and the second guidewire are configured to be received by a bone block, a first suture loop, a second suture loop, a first locking component, and a second locking component, in which the first locking component is coupled to the first suture loop and the second locking component is coupled to the second suture loop. The locking component has a hole formed therethrough, in which the hole of the locking component is configured to receive the suture, and may be tethered to a suture by knots engaging a counterbore at opposed ends of a bore defined by the hole.
摘要翻译: 外科组件包括第一导丝和第二导丝,其中第一导丝和第二导丝中的每一个被构造成由骨块,第一缝线环,第二缝合线环,第一锁定部件和 第二锁定部件,其中第一锁定部件联接到第一缝合线环,并且第二锁定部件联接到第二缝合线环。 锁定部件具有穿过其中形成的孔,其中锁定部件的孔构造成容纳缝合线,并且可以通过在由孔限定的孔的相对端处与沉孔接合的节点结合到缝合线。
-
-
-
-
-
-
-
-
-