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公开(公告)号：US07591979B2
公开(公告)日：2009-09-22
申请号：US10689316
申请日：2003-10-20
CPC分类号： G01N1/14 , G01N33/1886 , G01N35/1095 , G01N2001/022 , G01N2333/405 , G01N2520/00 , Y10T436/117497
摘要： An automatic, self-contained device for detecting toxic agents in a water supply includes an analyzer for detecting at least one toxic agent in a water sample, introducing means for introducing a water sample into the analyzer and discharging the water sample from the analyzer, holding means for holding a water sample for a pre-selected period of time before the water sample is introduced into the analyzer, and an electronics package that analyzes raw data from the analyzer and emits a signal indicating the presence of at least one toxic agent in the water sample.
摘要翻译： 一种用于检测供水中的有毒物质的自动独立装置，包括用于检测水样中的至少一种毒物的分析装置，用于将水样引入分析器的引入装置， 用于在将水样品引入分析仪之前将预先选定的时间段保持水样的装置，以及分析来自分析器的原始数据并发出指示至少一种有毒剂存在的信号的电子装置 水样。
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公开(公告)号：US07258836B2
公开(公告)日：2007-08-21
申请号：US10689261
申请日：2003-10-20
IPC分类号： G01N21/00
CPC分类号： B63B22/24 , B63B2035/4453
摘要： A freeze resistant buoy system includes a tail-tube buoy having a thermally insulated section disposed predominantly above a waterline, and a thermo-siphon disposed predominantly below the waterline.
摘要翻译： 防冻浮标系统包括具有主要位于水线以上的绝热部分的尾管浮标和主要位于水线下方的热虹吸管。
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公开(公告)号：US09222888B2
公开(公告)日：2015-12-29
申请号：US13438562
申请日：2012-04-03
申请人： Elias Greenbaum , Jie Wu
发明人： Elias Greenbaum , Jie Wu
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N2201/0625
摘要： Chlorophyll fluorometry may be used for detecting toxins in a sample because of changes in micro algae. A portable lab on a chip (“LOAC”) based chlorophyll fluorometer may be used for toxin detection and environmental monitoring. In particular, the system may include a microfluidic pulse amplitude modulated (“PAM”) chlorophyll fluorometer. The LOAC PAM chlorophyll fluorometer may analyze microalgae and cyanobacteria that grow naturally in source drinking water.
摘要翻译： 由于微藻的变化，叶绿素荧光测定法可用于检测样品中的毒素。 基于芯片的便携式实验室（“LOAC”）叶绿素荧光计可用于毒素检测和环境监测。 特别地，该系统可以包括微流体脉冲幅度调制（“PAM”）叶绿素荧光计。 LOAC PAM叶绿素荧光计可以分析在源饮用水中自然生长的微藻和蓝细菌。
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公开(公告)号：US08655452B2
公开(公告)日：2014-02-18
申请号：US13488302
申请日：2012-06-04
申请人： Elias Greenbaum , Mark S. Humayun
发明人： Elias Greenbaum , Mark S. Humayun
IPC分类号： A61N1/36
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译： 本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病性视网膜病变和视网膜和脉络膜组织缺血。 在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。 氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。
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公开(公告)号：US08198075B2
公开(公告)日：2012-06-12
申请号：US11271643
申请日：2005-11-10
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.
摘要翻译： 根据本发明的用于实时检测的水质分析器包括偏置AC电渗透（ACEO）电池，用于接收待分析的流体，其中具有多个光合生物，并将多个光合生物浓缩成至少一个集中区域 。 提供光电检测器用于获得在浓缩区域中的多个光合生物测量的光合活性，其中化学，生物或放射剂降低光合生物的标称光合活性。 电子组件分析测量的光合活性以指示流体中化学，生物或放射性剂的存在。
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公开(公告)号：US08812239B2
公开(公告)日：2014-08-19
申请号：US11302844
申请日：2005-12-14
CPC分类号： G06F19/00 , C12Q1/02 , C12Q1/22 , G01N2333/405
摘要： A method of biosensor-based detection of toxins includes the steps of providing a fluid to be analyzed having a plurality of photosynthetic organisms therein, wherein chemical, biological or radiological agents alter a nominal photosynthetic activity of the photosynthetic organisms. At a first time a measured photosynthetic activity curve is obtained from the photosynthetic organisms. The measured curve is automatically compared to a reference photosynthetic activity curve to determine differences therebetween. The presence of the chemical, biological or radiological agents, or precursors thereof, are then identified if present in the fluid using the differences.
摘要翻译： 一种基于生物传感器的毒素检测方法包括以下步骤：提供待分析的流体，其中具有多个光合生物，其中化学，生物或放射剂改变光合生物的标称光合活性。 第一次从光合生物获得测量的光合活性曲线。 测量曲线自动与参考光合活性曲线进行比较，以确定它们之间的差异。 然后如果使用差异存在于流体中，则鉴定化学，生物或放射性物质或其前体的存在。
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公开(公告)号：US20130023959A1
公开(公告)日：2013-01-24
申请号：US13488302
申请日：2012-06-04
申请人： Elias Greenbaum , Mark S. Humayun
发明人： Elias Greenbaum , Mark S. Humayun
IPC分类号： A61N1/36
摘要： The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.
摘要翻译： 本发明涉及治疗缺血性疾病，更具体地涉及治疗糖尿病视网膜病变和视网膜和脉络膜组织缺血。 在玻璃体切割的眼睛以及非玻璃体切割的眼睛中工作的治疗是基于玻璃体液的选择和分数电解以产生氧气和任选的活性氯，同时控制pH。 氧或活性氯可以抑制或逆转糖尿病性视网膜病变，其他视网膜血管疾病和脉络膜新血管形成。
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公开(公告)号：US20120238009A1
公开(公告)日：2012-09-20
申请号：US13431664
申请日：2012-03-27
IPC分类号： C12M1/34
CPC分类号： C12Q1/025
摘要： A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.
摘要翻译： 用于基于生物传感器的毒素检测系统包括在气体或液体介质中提供由生物传感器产生的至少一个与时间有关的控制信号，并从待监测的气体或液体介质中的生物传感器获得时间依赖的生物传感器信号 或分析一种或多种选自化学，生物或放射剂的毒素的存在。 处理时间依赖的生物传感器信号以使用幅度统计和时间 - 频率分析中的至少一个来获得多个特征向量。 然后，基于对控制信号的参考，从特征向量确定与气体或液体介质的毒性有关的至少一个参数。
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公开(公告)号：US20100267647A1
公开(公告)日：2010-10-21
申请号：US12824843
申请日：2010-06-28
申请人： Elias Greenbaum , Tanya Kuritz , Mark S. Humayun
发明人： Elias Greenbaum , Tanya Kuritz , Mark S. Humayun
CPC分类号： C07K14/705 , A61K38/00 , A61K41/0071
摘要： Photoreactivity in a cell is modulated by incorporating an isolated optical trigger on the surface or in the membrane of the cell. Exposure of a cell bearing incorporated optical triggers causes the generation of a measurable physiological signal.
摘要翻译： 细胞中的光反应性通过在细胞的表面或细胞膜上并入隔离的光触发来调节。 带有结合光学触发器的细胞的暴露导致产生可测量的生理信号。
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10.发明授权Measuring indigenous photosynthetic organisms to detect chemical warefare agents in water 失效测量土着光合生物以检测水中的化学成分物质公开(公告)号：US06964857B2
公开(公告)日：2005-11-15
申请号：US10339197
申请日：2003-01-09
CPC分类号： G01N33/5097 , C12Q1/02 , G01N2021/635 , G01N2520/00
摘要： A method of testing water to detect the presence of a chemical or biological warfare agent is disclosed. The method is carried out by establishing control data by providing control water containing indigenous organisms but substantially free of a chemical and a biological warfare agent. Then measuring photosynthetic activity of the control water with a fluorometer to obtain control data to compare with test data to detect the presence of the chemical or agent. The test data is gathered by providing test water comprising the same indigenous organisms as contained in the control water. Further, the test water is suspected of containing the chemical or agent to be tested for. Photosynthetic activity is also measured by fluorescence induction in the test water using a fluorometer.
摘要翻译： 公开了一种测试水以检测化学或生物战剂的存在的方法。 该方法是通过提供含有土着生物体的对照水，但基本上不含化学和生物战剂来建立控制数据来进行的。 然后用荧光计测量对照水的光合活性，以获得对照数据，与测试数据进行比较，以检测化学物质或药剂的存在。 通过提供包含对照水中所含的相同土着生物体的测试水来收集测试数据。 此外，试验水被怀疑含有待测试的化学品或试剂。 使用荧光计在测试水中通过荧光诱导来测量光合作用。
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