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公开(公告)号：US07150992B1
公开(公告)日：2006-12-19
申请号：US09699923
申请日：2000-10-30
申请人： David H. Lynch , Kenneth A. Brasel , Hilary J. McKenna , Luis G. Borges , Charles R. Maliszewski , Eugene Maraskovsky
发明人： David H. Lynch , Kenneth A. Brasel , Hilary J. McKenna , Luis G. Borges , Charles R. Maliszewski , Eugene Maraskovsky
CPC分类号： C12N5/0639 , A61K39/39541 , A61K2039/5154 , C12N2501/26 , A61K2300/00
摘要： Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic cells ex vivo. Such dendritic cells can then be used to present tumor, viral or other antigens to naive T cells, can be useful as vaccine adjuvants. When flt3-L is used and/or administered in combination with other reactive agents, e.g. CD40 binding proteins and 4-1BBL or antibodies reactive with 4-1BB, the combination further enhances immune responses and the effectiveness of vaccine adjuvants.
摘要翻译： Flt3-配体可用于从造血祖细胞和干细胞产生大量的树突状细胞。 Flt3-配体可用于增加体内的免疫应答，并离体扩展树突状细胞。 然后可以使用这种树突状细胞将肿瘤，病毒或其他抗原呈递给初始T细胞，可用作疫苗佐剂。 当使用flt3-L和/或与其它反应剂组合施用时， CD40结合蛋白和4-1BBL或与4-1BB反应的抗体，该组合进一步增强免疫应答和疫苗佐剂的有效性。
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2.发明授权Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) 失效免疫调节剂家族称为白细胞免疫球蛋白样受体（LIR）公开(公告)号：US06384203B1
公开(公告)日：2002-05-07
申请号：US09310463
申请日：1999-05-12
申请人： Dirk M. Anderson , Luis G. Borges
发明人： Dirk M. Anderson , Luis G. Borges
IPC分类号： C07H2104
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/70503 , C07K2319/00
摘要： A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
摘要翻译： 描述了免疫球蛋白超家族（LIR）多肽的新家族的免疫受体分子。 公开的是编码LIR家族成员及其推导的氨基酸序列的序列，由与定义的核苷酸序列杂交的DNA编码的多肽，用于产生LIR家族多肽的方法和针对LIR多肽的特异性抗体。 LIR家族成员可用于治疗与免疫功能受抑制相关的自身免疫疾病和疾病状态。
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公开(公告)号：US07875703B2
公开(公告)日：2011-01-25
申请号：US11981947
申请日：2007-10-31
申请人： Dirk M. Anderson , Luis G. Borges
发明人： Dirk M. Anderson , Luis G. Borges
IPC分类号： C07K14/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/70503 , C07K2319/00
摘要： A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
摘要翻译： 描述了免疫球蛋白超家族（LIR）多肽的新家族的免疫受体分子。 公开的是编码LIR家族成员及其推导的氨基酸序列的序列，由与定义的核苷酸序列杂交的DNA编码的多肽，用于产生LIR家族多肽的方法和针对LIR多肽的特异性抗体。 LIR家族成员可用于治疗与免疫功能受抑制相关的自身免疫疾病和疾病状态。
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公开(公告)号：US07067475B2
公开(公告)日：2006-06-27
申请号：US10357653
申请日：2003-02-03
IPC分类号： A01N37/18
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or conditions characterized by ocular neovascularization.
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5.发明授权公开(公告)号：US06413932B1
公开(公告)日：2002-07-02
申请号：US09590656
申请日：2000-06-07
IPC分类号： A61K3800
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or conditions characterized by ocular neovascularization.
摘要翻译： 本发明通过施用Tek拮抗剂来提供Tek拮抗剂和抑制哺乳动物血管生成的方法。 该方法特别可用于治疗由血管发生介导的疾病或病症，例如实体瘤和以眼新生血管形成为特征的疾病或病症。
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公开(公告)号：US20100080801A1
公开(公告)日：2010-04-01
申请号：US11981947
申请日：2007-10-31
申请人： Dirk M. Anderson , Luis G. Borges
发明人： Dirk M. Anderson , Luis G. Borges
IPC分类号： A61K39/395 , C07H21/04 , C07K14/435 , C07K16/18 , C12N15/63 , C12P21/06 , A61K38/17 , C12N5/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/70503 , C07K2319/00
摘要： A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
摘要翻译： 描述了免疫球蛋白超家族（LIR）多肽的新家族的免疫受体分子。 公开的是编码LIR家族成员及其推导的氨基酸序列的序列，由与定义的核苷酸序列杂交的DNA编码的多肽，用于产生LIR家族多肽的方法和针对LIR多肽的特异性抗体。 LIR家族成员可用于治疗与免疫功能受抑制相关的自身免疫疾病和疾病状态。
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公开(公告)号：US20080124340A1
公开(公告)日：2008-05-29
申请号：US11786879
申请日：2007-04-13
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/92
摘要： Antibodies that bind erythropoietin receptor are provided. Methods of making and using such antibodies are also provided. Kits containing such antibodies are also provided.
摘要翻译： 提供了结合促红细胞生成素受体的抗体。 还提供了制备和使用这些抗体的方法。 还提供了含有此类抗体的试剂盒。
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