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1.发明授权公开(公告)号：US06413932B1
公开(公告)日：2002-07-02
申请号：US09590656
申请日：2000-06-07
IPC分类号： A61K3800
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or conditions characterized by ocular neovascularization.
摘要翻译： 本发明通过施用Tek拮抗剂来提供Tek拮抗剂和抑制哺乳动物血管生成的方法。 该方法特别可用于治疗由血管发生介导的疾病或病症，例如实体瘤和以眼新生血管形成为特征的疾病或病症。
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公开(公告)号：US07067475B2
公开(公告)日：2006-06-27
申请号：US10357653
申请日：2003-02-03
IPC分类号： A01N37/18
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or conditions characterized by ocular neovascularization.
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公开(公告)号：US06949366B2
公开(公告)日：2005-09-27
申请号：US09904954
申请日：2001-07-12
IPC分类号： C12N15/09 , A61K38/00 , A61K38/19 , A61K39/395 , A61K51/00 , A61P35/00 , A61P35/02 , C07H21/02 , C07H21/04 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/24 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/19 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/52 , C07K2319/00 , C07K2319/30
摘要： Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.
摘要翻译： Hek配体（hek-L）多肽以及可用于提供hek-L多肽的DNA序列，载体和转化的宿主细胞。 hek-L多肽结合于作为受体酪氨酸激酶家族成员的细胞表面受体（hek）。 Hek在包含某些肿瘤细胞系的细胞上表达。 hek-L多肽还结合不同受体酪氨酸激酶已知的麋鹿。
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公开(公告)号：US06555354B2
公开(公告)日：2003-04-29
申请号：US09726968
申请日：2000-11-29
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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公开(公告)号：US06492140B2
公开(公告)日：2002-12-10
申请号：US09754105
申请日：2001-01-03
IPC分类号： C12P2102
CPC分类号： C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/34 , C07K2319/00
摘要： LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
摘要翻译： 公开了LERK-5多肽以及可用于产生LERK-5的DNA序列载体和转化的宿主细胞。 LERK-5多肽与elk和hek结合，它们是受体酪氨酸激酶的eph / elk家族的成员。
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公开(公告)号：US06479459B1
公开(公告)日：2002-11-12
申请号：US08739333
申请日：1996-10-29
IPC分类号： A61K3819
CPC分类号： C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/34 , C07K2319/00
摘要： LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
摘要翻译： 公开了LERK-5多肽以及可用于产生LERK-5的DNA序列载体和转化的宿主细胞。 LERK-5多肽与elk和hek结合，它们是受体酪氨酸激酶的eph / elk家族的成员。
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公开(公告)号：US06472174B1
公开(公告)日：2002-10-29
申请号：US09580236
申请日：2000-05-26
申请人： Douglas P. Cerretti
发明人： Douglas P. Cerretti
IPC分类号： C12N1509
CPC分类号： C07K16/20 , A01K2217/05 , A61F2013/00153 , C07K14/52 , C07K2319/00
摘要： The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.
摘要翻译： 本发明涉及作为纯化和分离的蛋白质的LERK-6，编码LERK-6的DNA，用编码LERK-6的cDNA转染的宿主细胞。
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公开(公告)号：US06406877B2
公开(公告)日：2002-06-18
申请号：US09727169
申请日：2000-11-29
IPC分类号： C12Q137
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US5108911A
公开(公告)日：1992-04-28
申请号：US392332
申请日：1989-08-11
IPC分类号： A61K38/00 , C07K14/545 , C12N15/25
CPC分类号： C07K14/545 , A61K38/00
摘要： A process for preparing bovine interleukin I.beta. (bIL-1.beta.) by culturing a microbial host transformed by a vector containing a DNA sequence encoding bIL-1.beta. under conditions suitable for the expression of bIL-1.beta. and recovering bIL-1.beta..
摘要翻译： 通过培养由含有编码bIL-1β的DNA序列的载体在适于表达bIL-1β并恢复bIL-1β的条件下转化的微生物宿主来制备牛白介素Iβ（bIL-1β）的方法。
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公开(公告)号：US5106733A
公开(公告)日：1992-04-21
申请号：US355870
申请日：1989-05-22
申请人： Paul E. Baker , Douglas P. Cerretti , William R. Clevenger , David J. Cosman , Charles R. Maliszewski
发明人： Paul E. Baker , Douglas P. Cerretti , William R. Clevenger , David J. Cosman , Charles R. Maliszewski
IPC分类号： A61K38/00 , C07K14/535 , C12N15/62
CPC分类号： C12N15/625 , C07K14/535 , C12N15/62 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75
摘要： Cloning and expression of DNA segments encoding bovine GM-CSF, and processes for producing recombinant bovine GM-CSF as a product of recombinant cell culture, are disclosed.
摘要翻译： 公开了编码牛GM-CSF的DNA片段的克隆和表达，以及用于产生作为重组细胞培养物的产物的重组牛GM-CSF的方法。
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