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    Method for protection against tumor metastasis formation
    1.
    发明授权
    Method for protection against tumor metastasis formation 失效
    保护肿瘤转移形成的方法

    公开(公告)号：US06984619B1

    公开(公告)日：2006-01-10

    申请号：US09523886

    申请日：2000-03-13

    申请人： David J. Grdina ,  Luka Milas

    发明人： David J. Grdina ,  Luka Milas

    IPC分类号： A01N61/00 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： A61K31/661 ,  A61K31/66 ,  A61K41/00 ,  A61K2300/00

    摘要： Methods and pharmaceuticals for inhibiting or preventing metastasis formation in animals, including humans, having primary tumors, through the administration of phosphorothioates including their thiol and disulfide metabolites are disclosed. These compounds stimulate angiostatin levels, inhibit matrix metalloproteinases (MMPs), and stimulate manganese superoxidase dismutase (MnSOD). Phosphorothioates, of which amifostine is an example, can be administered as a combination therapy with traditional cancer therapies, including chemotherapy, radiotherapy, surgery, immunotherapy, hormone therapy and gene-therapy. Inhibition or prevention of metastasis by phosphorothioates is independent of tumor type, including adenocarcinomas and sarcomas.

    摘要翻译： 公开了通过施用硫代磷酸酯包括它们的硫醇和二硫化物代谢物来抑制或预防具有原发性肿瘤的动物包括人在内的转移形成的方法和药物。 这些化合物刺激血管内皮抑素水平，抑制基质金属蛋白酶（MMPs），并刺激锰超氧化物歧化酶（MnSOD）。 以氨磷汀为例的硫代磷酸酯可以作为与传统癌症治疗（包括化学疗法，放射治疗，手术，免疫治疗，激素治疗和基因治疗）的联合治疗来施用。 通过硫代磷酸酯抑制或预防转移与肿瘤类型无关，包括腺癌和肉瘤。

    METHODS AND COMPOSITIONS FOR PROTECTION OF CELLS AND TISSUES FROM COMPUTED TOMOGRAPHY RADIATION
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR PROTECTION OF CELLS AND TISSUES FROM COMPUTED TOMOGRAPHY RADIATION 有权
    用于保护计算机图像辐射的细胞和组织的方法和组合物

    公开(公告)号：US20130251634A1

    公开(公告)日：2013-09-26

    申请号：US13822223

    申请日：2011-09-16

    申请人： David J. Grdina

    发明人： David J. Grdina

    IPC分类号： A61K31/661 ,  A61K49/00 ,  A61K45/06 ,  A61B6/03 ,  A61K31/145

    CPC分类号： A61K31/661 ,  A61B6/032 ,  A61B6/508 ,  A61K31/132 ,  A61K31/145 ,  A61K31/355 ,  A61K33/04 ,  A61K45/06 ,  A61K49/0008 ,  A61K2300/00

    摘要： Described are methods for preventing or inhibiting genomic instability and in cells affected by diagnostic radiology procedures employing ionizing radiation. Embodiments include methods of preventing or inhibiting genomic instability and in cells affected by computed tomography (CT) radiation. Subjects receiving ionizing radiation may be those persons suspected of having cancer, or cancer patients having received or currently receiving cancer therapy, and or those patients having received previous ionizing radiation, including those who are approaching or have exceeded the recommended total radiation dose for a person.

    摘要翻译： 描述了用于预防或抑制基因组不稳定性和在使用电离辐射的诊断放射学程序影响的细胞中的方法。 实施方案包括预防或抑制基因组不稳定性和受计算机断层摄影（CT）辐射影响的细胞的方法。 接受电离辐射的受试者可能是那些怀疑患有癌症的人，或已经接受或正在接受癌症治疗的癌症患者，以及接受了以前电离辐射的那些患者，包括接近或已经超过人的推荐总辐射剂量的那些 。