摘要:
A core sample from an oil or gas well can be quickly and easily inserted and removed relative to a reusable sealing sleeve fixed within a test housing wherein the core sample is tested for both longitudinal and lateral strain in response to applied stress. Young's modulus and Poisson's ratio can be determined from the strain and stress information. Pressures and temperature can be set to simulate downhole conditions inside the apparatus.
摘要:
The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
摘要:
A multiple fluid dispensing device is provided which includes a plurality of liquid formulations with at least one formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulations in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulations in separate compartments, and forces the liquid formulations through the tip when compressed. The inner bottle is configured with a volume for preventing the liquid formulations from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.
摘要:
The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
摘要:
The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
摘要:
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions have improved bioavailability, are capable of low dose volume delivery, and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
摘要:
Methods of completing poorly consolidated subterranean formations bounded by one or more consolidated formations to prevent sand production from the poorly consolidated formations are provided. The methods basically comprise the steps of drilling a well bore into the consolidated boundary formation adjacent to the poorly consolidated formation, creating a propped fracture communicating with the well bore in the consolidated boundary formation which extends into the poorly consolidated formation and producing fluids from the poorly consolidated formation into the well bore by way of the propped fracture.
摘要:
The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要:
The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.
摘要:
The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.