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17 条记录 (耗时 0.159 秒)

    Adjustable dose injection pistol
    1.
    发明授权
    Adjustable dose injection pistol 失效
    可调剂量注射手枪

    公开(公告)号：US4564360A

    公开(公告)日：1986-01-14

    申请号：US536744

    申请日：1983-09-28

    申请人： David M. Young ,  Andrew W. Blower

    发明人： David M. Young ,  Andrew W. Blower

    IPC分类号： A61M5/20 ,  A61M5/315 ,  B05C17/005 ,  B05C17/01 ,  G01F11/02 ,  A61D7/00

    CPC分类号： A61M5/3158 ,  A61M5/31553 ,  B05C17/00569 ,  B05C17/01 ,  G01F11/023 ,  A61M5/3156 ,  A61M5/31591

    摘要： There is described an adjustable dose injection pistol comprising a body assembly (1) including an elongate chamber (8), a piston chamber (3) including a piston (13) slideable in the chamber (8) between filled and discharged positions and means for adjusting (16, 26, 19, 20, 22, 23) one of said positions.The means comprise a selectable plurality of channels (20, 22, 23) included in one of the assemblies (1, 3), the channels (20, 22, 23) being spaced about and parallel to the piston-chamber axis, and an arrestor (19) located on the other assembly (1, 3), the arrestor (19) being selectably engageable with an aligned channel (20, 22, 23) upon movement of said piston (13) between said positions.The channels (20, 22, 23) are preferably located in the piston assembly (3) on a sleeve (16) concentrically mounted with the piston (13) and rotable with respect to the chamber (8).The pistol may be used for the injection of liquids into animals.

    摘要翻译： 描述了可调剂量注射手枪，其包括主体组件（1），其包括细长室（8），活塞室（3），其包括可在填充和排出位置之间在室（8）中滑动的活塞（13），以及用于 调整（16,26,19,20,22,23）所述位置之一。 所述装置包括包括在所述组件（1,3）中的一个中的可选择的多个通道（20,22,23），所述通道（20,22,23）在活塞室轴线周围并且平行于所述通道 位于另一组件（1,3）上的避雷器（19），所述止动器（19）在所述活塞（13）在所述位置运动时可选择地与对准的通道（20,22,23）接合。 通道（20,22,23）优选地位于同心地安装有活塞（13）并且可相对于腔室（8）旋转的套筒（16）上的活塞组件（3）中。 手枪可用于将液体注入动物。

    Nerve growth factor
    2.
    发明授权
    Nerve growth factor 失效
    神经生长因子

    公开(公告)号：US4185095A

    公开(公告)日：1980-01-22

    申请号：US854194

    申请日：1977-11-23

    申请人： David M. Young

    发明人： David M. Young

    IPC分类号： A61K35/37 ,  A61K38/00 ,  A61P25/00 ,  C07K14/48 ,  A61K35/12 ,  A61K37/02 ,  C07G7/00

    CPC分类号： C07K14/48 ,  A61K38/00 ,  Y10S530/843 ,  Y10S530/854

    摘要： A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.

    摘要翻译： 从小鼠颌下腺或小鼠唾液中获得分子量为约116,000并且在稀水溶液中稳定的新形式的神经生长因子。 将小鼠颌下腺或小鼠唾液的提取物进行离子交换层析以回收富含神经生长因子的腺体或唾液的成分，并含有不降解神经生长因子的蛋白质物质。 纯神经生长因子通过将富含神经生长因子的组分进行至少一个另外的色谱步骤（通常为2-4）来获得，以回收分子量为约116,000的纯神经生长因子。

    Non-isotopic substrate assay employing bacteriolysis products
    3.
    发明授权
    Non-isotopic substrate assay employing bacteriolysis products 失效
    使用溶菌产物的非同位素底物测定

    公开(公告)号：US4104126A

    公开(公告)日：1978-08-01

    申请号：US743413

    申请日：1976-11-19

    申请人： David M. Young

    发明人： David M. Young

    IPC分类号： C12Q1/34 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/58 ,  G01N31/14

    CPC分类号： G01N33/53 ,  C12Q1/34 ,  C12Q1/70 ,  G01N33/58

    摘要： Substrates such as haptens and antigens, and those for receptor proteins and native circulating binding proteins are assayed by determining bacteriolysis products occasioned by bacteriophage infection of host cells, in a modification of the "chemically modified bacteriophage assay." Thus, a substrate such as an antigen is conjugated with bacteriophage and the conjugate competes with antigen in the specimen under assay for a limited number of binding sites on antibody. Phage conjugate surviving antibody inactivation is quantified by determining intracellular constituents of host bacteria subsequently infected by the bacteriophage remaining viable, which latter can be related to the levels of antigen originally present in the specimen. A preferred embodiment involves colorimetric assay for beta galactosidase freed by phage lysis of E. coli. Generally, the method is of sensitivity comparable to that of radioimmunoassay, but is attended by substantial advantages not common to the latter technique. The method is far less cumbersome than the plaque-containing techniques hitherto employed in bacteriophage assays.

    摘要翻译： 在“化学修饰的噬菌体测定”的修饰中，通过确定由宿主细胞的噬菌体感染引起的细菌溶解产物来测定底物如半抗原和抗原，以及受体蛋白和天然循环结合蛋白的底物。 因此，诸如抗原的底物与噬菌体缀合，并且缀合物与抗体中有限数目的结合位点在测定中与抗体在抗体中竞争。 噬菌体缀合物存活的抗体失活通过确定随后被残留存活的噬菌体感染的宿主细菌的细胞内成分进行定量，后者可与原始存在于样品中的抗原水平相关。 优选的实施方案涉及通过噬菌体裂解大肠杆菌释放的β-半乳糖苷酶的比色测定。 通常，该方法的灵敏度与放射免疫测定相当，但是由于后一种技术不常见的实质性优点而存在。 该方法远远不如迄今在噬菌体测定中使用的含有噬斑的技术麻烦。

    HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing
    5.
    发明授权
    HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing 有权
    HoxD3，HoxA3和HoxB3组合物和改善伤口愈合的方法

    公开(公告)号：US07157439B2

    公开(公告)日：2007-01-02

    申请号：US10746592

    申请日：2003-12-23

    申请人： Nancy Boudreau ,  David M. Young ,  Cornelia Myers

    发明人： Nancy Boudreau ,  David M. Young ,  Cornelia Myers

    IPC分类号： A61K31/70 ,  A61K9/127 ,  A61K39/21 ,  C07H21/04 ,  C07K1/04

    CPC分类号： A61K48/00 ,  A61K38/00 ,  A61K48/005 ,  C07K14/4702

    摘要： The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving and/or controlling wound healing by applying a wound care device comprising HoxD3 and/or HoxA3 and/or HoxB3. In addition, the present invention provides methods and compositions for improved wound healing in subjects having impaired healing capabilities, such as diabetic subjects.

    摘要翻译： 本发明提供了可用于遗传物质或蛋白质的局部转移的方法和组合物。 此外，本发明提供了通过应用包含HoxD3和/或HoxA3和/或HoxB3的伤口护理装置来改善和/或控制伤口愈合的方法和组合物。 此外，本发明提供了用于改善伤口愈合的方法和组合物，所述受试者具有受损的愈合能力，例如糖尿病受试者。

    Mechanical lockout for a pneumatic tool
    6.
    发明授权
    Mechanical lockout for a pneumatic tool 失效
    机械锁定用于气动工具

    公开(公告)号：US5320187A

    公开(公告)日：1994-06-14

    申请号：US993417

    申请日：1992-12-21

    申请人： Jack Pressley ,  John Knott ,  David M. Young ,  Pradip K. Paul ,  Richard Wilusz

    发明人： Jack Pressley ,  John Knott ,  David M. Young ,  Pradip K. Paul ,  Richard Wilusz

    IPC分类号： B25D17/04 ,  B25D17/08 ,  B25D17/10

    CPC分类号： B25D17/04 ,  B25D17/08 ,  B25D2250/265

    摘要： The invention is a safety mechanism for an air-powered tool. The mechanism senses the position of the tool's implement retainer and disables the air flow to the tool's motor if the retainer is not in its locked position. The mechanism employs a pushrod that has one end adapted to contact a rear surface of the retainer when the retainer is in its lock position. The other end of the pushrod is adapted to contact a spring-biased ball-type check valve located within the air inlet to the tool's motor. When the retainer is removed from the tool, the pushrod moves forwardly under the urging of the valve and at the same time allows the valve to move to its closed position to thereby prevent any flow of pressurized air to the motor.

    摘要翻译： 本发明是用于空气动力工具的安全机构。 如果保持器不在其锁定位置，该机构将感测工具的工具保持器的位置，并禁止气体流向工具的电机。 该机构采用推杆，当保持器处于其锁定位置时，该推杆的一端适于接触保持器的后表面。 推杆的另一端适于接触位于工具电机的进气口内的弹簧偏压球形止回阀。 当保持器从工具移除时，推杆在阀的推动下向前移动，并且同时允许阀移动到其关闭位置，从而防止加压空气流到马达。

    Production of 1,4 Butanediol in a Microorganism
    7.
    发明申请
    Production of 1,4 Butanediol in a Microorganism 审中-公开
    在微生物中生产1,4-丁二醇

    公开(公告)号：US20110014669A1

    公开(公告)日：2011-01-20

    申请号：US12692943

    申请日：2010-01-25

    申请人： Kevin T. Madden ,  David M. Young ,  Stanley Bower ,  Chi-Li Liu

    发明人： Kevin T. Madden ,  David M. Young ,  Stanley Bower ,  Chi-Li Liu

    IPC分类号： C12P7/18 ,  C12N1/00 ,  C12N1/21

    CPC分类号： C12P7/18 ,  C12N15/52 ,  C12P7/16 ,  C12P7/24 ,  C12P7/42 ,  C12P13/02 ,  Y02E50/10

    摘要： A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol.

    摘要翻译： 描述了将涉及脱羧步骤并避免生成4-羟基丁酸酯作为中间体的L-谷氨酸转化为1,4-丁二醇的生物学方法。 该方法包括：（a）将L-谷氨酸转化为L-谷氨酸5-磷酸; （b）将L-谷氨酸5-磷酸转化为L-谷氨酸5-半醛; （c）将L-谷氨酸5-半醛转化为5-羟基-L-正缬氨酸; （d）将5-羟基-L-正缬氨酸转化为5-羟基-2-氧代戊酸酯; （e）将5-羟基-2-氧代戊酸转化为4-羟基丁醛; 和（f）将4-羟基丁醛转化为1,4-丁二醇。

    Retainer for a pneumatic tool
    8.
    发明授权
    Retainer for a pneumatic tool 失效
    气动工具固定器

    公开(公告)号：US5522606A

    公开(公告)日：1996-06-04

    申请号：US301656

    申请日：1994-09-07

    申请人： Jack Pressley ,  David M. Young ,  John Knott ,  Thomas Wastowicz

    发明人： Jack Pressley ,  David M. Young ,  John Knott ,  Thomas Wastowicz

    IPC分类号： B25D17/08

    CPC分类号： B25D17/08 ,  Y10T279/17094 ,  Y10T279/17881 ,  Y10T403/7005 ,  Y10T403/7073 ,  Y10T403/7098

    摘要： A retainer for a pneumatic tool and assembly therefor is disclosed. The retainer includes a tool body having an internal surface defining a bore and an external surface having a threaded portion. A retainer cap is used with the tool body and includes an internal surface having a threaded portion adapted to engage the threaded portion of the tool body. An insert having an outer surface is rotatably mounted in the retainer cap. The insert includes an inner surface with a first inner surface portion adapted for conforming with a non-circular lug surface of a tool shank and a second inner surface portion radially offset from the first portion adapted for conforming with the non-circular lug surface.

    摘要翻译： 公开了一种用于气动工具及其组件的保持器。 保持器包括具有限定孔的内表面和具有螺纹部分的外表面的工具主体。 保持盖与工具主体一起使用并且包括具有适于接合工具主体的螺纹部分的螺纹部分的内表面。 具有外表面的插入件可旋转地安装在保持器盖中。 插入件包括具有第一内表面部分的内表面，该第一内表面部分适于与工具柄的非圆形凸耳表面相符合，以及第二内表面部分，该第二内表面部分与第一部分径向偏离，以适应于与非圆形凸耳表面一致。