公开(公告)号：US20050137662A1

公开(公告)日：2005-06-23

申请号：US11034435

申请日：2005-01-11

申请人： David Morris ,  Steven Daniel ,  Daniel Balbierz

发明人： David Morris ,  Steven Daniel ,  Daniel Balbierz

IPC分类号： A61B18/14 ,  A61F2/00

CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

摘要： A tissue surface treatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactinc surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy delivery device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode from the housing interior into the target tissue site and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.

摘要翻译： 组织表面处理设备包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。 触点表面具有多个孔。 包括电极的能量输送装置可定位在壳体内部。 电极包括与孔基本对准的穿透远端的组织。 电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。 进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。 推进装置被配置为将电极从壳体内部推进到目标组织部位并将电极抽出到壳体内部。 电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

公开(公告)号：US20050070896A1

公开(公告)日：2005-03-31

申请号：US10890055

申请日：2004-07-12

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14 ,  A61B19/00

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： A coagulation system is provided for use in biological tissue. The coagulation system includes a handle, a radiofrequency (RF) generator, and an electrode array. The electrode array includes two or more pair of bipolar electrodes slideably coupled in channels of the handle. The bipolar electrodes electrically couple to the RF generator, and the electrode array is configured to deliver a balanced energy density in a target volume of the biological tissue. The balanced energy density delivered by the electrode array results in thermal coagulation necrosis of a rectangular volume of biological tissue.

摘要翻译： 提供用于生物组织的凝血系统。 凝结系统包括手柄，射频（RF）发生器和电极阵列。 电极阵列包括可滑动地联接在手柄的通道中的两对或更多对双极电极。 双极电极电耦合到RF发生器，并且电极阵列被配置为在生物组织的靶体积中传递平衡的能量密度。 由电极阵列传递的平衡能量密度导致生物组织的矩形体积的热凝固坏死。

公开(公告)号：US20060100620A1

公开(公告)日：2006-05-11

申请号：US11256500

申请日：2005-10-20

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B2018/0016 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1475

摘要： Energy delivery systems and methods are provided for use in biological tissue. The energy delivery system includes a handle, a radiofrequency (RF) generator, and an electrode array. The electrode array includes two or more pair of bipolar electrodes slideably coupled in channels of the handle. The bipolar electrodes electrically couple to the RF generator, and the electrode array is configured to deliver a balanced energy density in a target volume of the biological tissue. The balanced energy density delivered by the electrode array results in generation of a hemostatic plane of tissue.

摘要翻译： 提供能量输送系统和方法用于生物组织。 能量输送系统包括手柄，射频（RF）发生器和电极阵列。 电极阵列包括可滑动地联接在手柄的通道中的两对或更多对双极电极。 双极电极电耦合到RF发生器，并且电极阵列被配置为在生物组织的靶体积中传递平衡的能量密度。 由电极阵列传递的平衡能量密度导致组织的止血平面的产生。

公开(公告)号：US20060217707A1

公开(公告)日：2006-09-28

申请号：US11335295

申请日：2006-01-18

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/143

摘要： Energy delivery systems and methods are provided for use in biological tissue. The energy delivery system includes an energy source and an electrode array. The electrode array includes bipolar electrodes positioned so a first spacing between a pair of adjacent electrodes is different relative to a second spacing between at least one other pair of adjacent electrodes. The electrode array and the energy source are coupled and configured to generate uniform energy density in target tissue according to impedance of the target tissue.

公开(公告)号：US20050049586A1

公开(公告)日：2005-03-03

申请号：US10889756

申请日：2004-07-12

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/148 ,  A61B2018/00267

摘要： An ablation device is described comprising an introducer and an electrode array. The electrode array couples to a distal end of the introducer. The electrode array includes a center member having a distal end configured to penetrate tissue and a plurality of electrodes. Proximal and distal ends of each electrode are relatively fixed. The electrodes are dynamically configurable from a retracted state to a deployed state in which the electrodes form a relatively spherical shape in a tissue volume.

摘要翻译： 描述了包括导引器和电极阵列的消融装置。 电极阵列耦合到导引器的远端。 电极阵列包括具有构造成穿透组织的远端和多个电极的中心构件。 每个电极的近端和远端相对固定。 电极可以从缩回状态动态地配置到展开状态，其中电极在组织体积中形成相对球形的形状。

公开(公告)号：US20060142757A1

公开(公告)日：2006-06-29

申请号：US11335092

申请日：2006-01-18

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： A tissue ablation system is described that generates a uniform avascular plane of coagulated tissue to aid in the bloodless or near-bloodless resection of various biological tissues from a variety of organs. The tissue ablation system includes an energy director guide and two or more sets of bipolar energy directors. The energy director guide includes a series of channels that configure the energy directors to provide approximately uniform power distribution or current density through a target tissue volume or plane. The spacing among the channels of the energy director guide varies according to the total number of energy directors received in the energy director guide so that relative spacing among the center-most channels is largest and relative spacing among the end-most channels is smallest. The energy director guide secures a selected position of each of the energy directors in the target tissue volume.

摘要翻译： 描述了组织消融系统，其产生凝固组织的均匀的无血管平面，以帮助来自各种器官的各种生物组织的无血或近无血的切除。 组织消融系统包括能量导向器引导件和两组或多组双极能量引导器。 能量导向器引导件包括一系列通道，其配置能量引导器以通过目标组织体积或平面提供近似均匀的功率分布或电流密度。 能量导向器引导件的通道之间的间隔根据能量导向器引导器中接收到的能量引导器的总数而变化，使得最中心的通道之间的相对间隔最大，并且最终通道之间的相对间隔最小。 能量导向器引导件将每个能量引导器的选定位置固定在目标组织体积中。

公开(公告)号：US20060212032A1

公开(公告)日：2006-09-21

申请号：US11335301

申请日：2006-01-18

申请人： Steven Daniel ,  David Morris ,  Kee Lee

发明人： Steven Daniel ,  David Morris ,  Kee Lee

IPC分类号： A61B18/14

CPC分类号： A61B18/148 ,  A61B18/1477 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

摘要： A tissue ablation device and method for tissue ablation are described. The tissue ablation device comprises an energy source and an introducer coupled to the energy source, the introducer having a body, a proximal end, and a distal end. The introducer carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the body of the introducer when moved from a retracted state to a deployed state. The electrode array is designed to encircle a portion of a target tissue when the electrodes are extended into the deployed state and to form a relatively spherical shaped ablation pattern in a tissue volume surrounding the target tissue when energized by the energy source.

摘要翻译： 描述了用于组织消融的组织消融装置和方法。 组织消融装置包括能量源和耦合到能量源的导引器，导入器具有主体，近端和远端。 引导器携带包括多个电极的电极阵列，多个电极中的每个电极构造成当从缩回状态移动到展开状态时，从引导器的主体延伸。 当电极延伸到展开状态时，电极阵列被设计成环绕目标组织的一部分，并且在被能量源激励时围绕目标组织的组织体积中形成相对球形的消融图案。

公开(公告)号：US20050004567A1

公开(公告)日：2005-01-06

申请号：US10800451

申请日：2004-03-15

申请人： Steven Daniel ,  David Morris

发明人： Steven Daniel ,  David Morris

IPC分类号： A61B18/14 ,  A61B19/00 ,  A61M31/00

CPC分类号： A61B18/1477 ,  A61B90/11 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1475

摘要： Methods for performing coagulation necrosis of biological tissue are provided. The methods include configuring electrode arrays to provide balanced energy density in target tissue volumes using two or more pair of electrodes. The electrode array configuration includes at least one of irregular spacing between one or more pairs of electrodes and one or more electrode diameters. The methods further include deploying each electrode of an array at a selected depth in the target tissue volume in accordance with the configuration. Energy is then delivered to the target tissue volume using power sources coupled to the electrodes. The methods control power delivery in response to at least one of elapsed time of delivery, temperatures of the target tissue volume, and impedance levels in the target tissue volume to provide balanced or uniform energy throughout the target tissue volume. The methods generate planes of coagulated tissue.

摘要翻译： 提供了生物组织凝固坏死的方法。 所述方法包括配置电极阵列以使用两对或更多对电极在目标组织体积中提供平衡的能量密度。 电极阵列配置包括一对或多对电极之间的不规则间隔和一个或多个电极直径中的至少一个。 所述方法还包括根据配置将阵列的每个电极部署在目标组织体积中的选定深度处。 然后使用耦合到电极的电源将能量输送到目标组织体积。 所述方法响应于经过的传递时间，目标组织体积的温度和目标组织体积中的阻抗水平中的至少一个来控​​制功率传递，以在整个目标组织体积中提供平衡或均匀的能量。 该方法产生凝结组织的平面。

公开(公告)号：US06368794B1

公开(公告)日：2002-04-09

申请号：US09232160

申请日：1999-01-15

申请人： Steven Daniel ,  James Gilmore ,  Susan G. Stuart ,  Laura L. Stuve

发明人： Steven Daniel ,  James Gilmore ,  Susan G. Stuart ,  Laura L. Stuve

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N2799/026 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention relates to polynucleotides comprising genes that regulate cell proliferation. The present invention also relates to a method for diagnosing or monitoring the treatment of a disease characterized by the altered expression of genes that regulate cell proliferation in a sample.

摘要翻译： 本发明涉及包含调节细胞增殖的基因的多核苷酸。 本发明还涉及用于诊断或监测治疗疾病的方法，其特征在于调节样品中细胞增殖的基因表达的改变。

公开(公告)号：US08393429B2

公开(公告)日：2013-03-12

申请号：US12938861

申请日：2010-11-03

申请人： Norval Thomson ,  Steven Daniel ,  Daniel Sergison

发明人： Norval Thomson ,  Steven Daniel ,  Daniel Sergison

IPC分类号： B62D61/12 ,  B62K13/00

CPC分类号： E02F5/32 ,  B62D49/0678 ,  E02F3/764 ,  E02F3/7659 ,  E02F3/7668 ,  E02F3/7672 ,  E02F3/961 ,  E02F9/024 ,  E02F9/225

摘要： A motor grader with an adjustable wheelbase. The motor grader may include front and rear wheels supporting a chassis and a main frame. A working blade may downwardly depend from the main frame between the front wheels and rear wheels to perform work on the ground below. The motor grader may also provide an adjustable wheel base to allow the center of gravity of the motor grader to better match the work load being addressed. The adjustable wheel base may also provide more swing clearance for the blade relative to the rear wheels, allow for an adjustable articulation angle, and minimize structural loads on the motor grader, particularly during ripping operation. The wheel base may be adjustable by providing structure through which the relative positions of the rear wheels can be altered automatically, manually, and dynamically.

摘要翻译： 具有可调节轴距的自动平地机。 自动平地机可以包括支撑底盘和主框架的前轮和后轮。 工作叶片可以从前轮和后轮之间的主框架向下依次，以在下面的地面上进行作业。 自动平地机还可以提供可调轮盘，以允许分级机的重心更好地匹配要解决的工作负荷。 可调轮底还可以为叶片相对于后轮提供更多的摆动间隙，允许可调节的关节角度，并且最小化马达分级机上的结构负载，特别是在翻转操作期间。 车轮底座可以通过提供可以自动，手动和动态地改变后轮的相对位置的结构来调节。