公开(公告)号：US08454516B1

公开(公告)日：2013-06-04

申请号：US09617318

申请日：2000-07-17

申请人： David N. Roundhill ,  Michalakis Averkiou ,  Jeffry E. Powers

发明人： David N. Roundhill ,  Michalakis Averkiou ,  Jeffry E. Powers

IPC分类号： A61B8/00

CPC分类号： G01S15/895 ,  A61B8/08 ,  A61B8/14 ,  A61B8/463 ,  A61B8/488 ,  G01S7/52026 ,  G01S7/52033 ,  G01S7/52036 ,  G01S7/52038 ,  G01S7/52046 ,  G01S7/5206 ,  G01S7/52074 ,  G01S7/52077 ,  G01S15/8979 ,  G01S15/8993

摘要： An ultrasonic diagnostic imaging system and method are described which produce tissue harmonic images containing both fundamental and harmonic frequency components. Such a blended image takes advantage of the performance possible with the two types of ultrasonic echo information and can advantageously reduce near field clutter while improving signal to noise performance in the far field of the image.

摘要翻译： 描述了产生包含基波和谐波频率分量的组织谐波图像的超声波诊断成像系统和方法。 这种混合图像利用两种类型的超声波回波信息来利用可能的性能，并且可以有利地减少近场杂波，同时提高图像的远场中的信噪比性能。

公开(公告)号：US06623432B2

公开(公告)日：2003-09-23

申请号：US09908294

申请日：2001-07-17

申请人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick Rene' Pesque

发明人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick Rene' Pesque

IPC分类号： A61B800

CPC分类号： A61B8/483 ,  A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/4472 ,  A61B8/481 ,  A61B8/543 ,  G01S7/52025 ,  G01S7/52074 ,  G01S7/5208 ,  G01S7/52095 ,  G01S15/8918 ,  G01S15/8925 ,  G01S15/894 ,  G01S15/8963 ,  G01S15/8979 ,  G01S15/8993 ,  G10K11/341 ,  Y10S128/916

摘要： An ultrasonic imaging method and apparatus are described for imaging the coronary arteries of the heart. The vascular system is infused with an ultrasonic contrast agent. A volumetric region of the heart wall including a coronary artery is three dimensionally scanned. A projection image of the volumetric region is produced from the scanning, providing a two dimensional contrast image of the coronary artery with the appearance of an angiogram. Preferably the coronary artery signals are segmented from contrast signals emanating from the myocardium and the heart blood pool so that the coronary arteries are clearly highlighted and distinct in the ultrasonic angiogram.

公开(公告)号：US06283919B1

公开(公告)日：2001-09-04

申请号：US09247343

申请日：1999-02-08

申请人： David N. Roundhill ,  Michalakis Averkiou ,  Jeffry E. Powers

发明人： David N. Roundhill ,  Michalakis Averkiou ,  Jeffry E. Powers

IPC分类号： A61B800

CPC分类号： G01S15/895 ,  A61B8/08 ,  A61B8/14 ,  A61B8/463 ,  A61B8/488 ,  G01S7/52026 ,  G01S7/52033 ,  G01S7/52036 ,  G01S7/52038 ,  G01S7/52046 ,  G01S7/5206 ,  G01S7/52074 ,  G01S7/52077 ,  G01S15/8979 ,  G01S15/8993

摘要： An ultrasonic diagnostic imaging system and method are described which produce tissue harmonic images containing both fundamental and harmonic frequency components. Such a blended image takes advantage of the performance possible with the two types of ultrasonic echo information and can advantageously reduce near field clutter while improving signal to noise performance in the far field of the image.

摘要翻译： 描述了产生包含基波和谐波频率分量的组织谐波图像的超声波诊断成像系统和方法。 这种混合图像利用两种类型的超声波回波信息来利用可能的性能，并且可以有利地减少近场杂波，同时提高图像的远场中的信噪比性能。

公开(公告)号：US06471650B2

公开(公告)日：2002-10-29

申请号：US09919681

申请日：2001-07-31

申请人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick René Pesque

发明人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick René Pesque

IPC分类号： A61B800

CPC分类号： A61B8/483 ,  A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/4472 ,  A61B8/481 ,  A61B8/543 ,  G01S7/52025 ,  G01S7/52074 ,  G01S7/5208 ,  G01S7/52095 ,  G01S15/8918 ,  G01S15/8925 ,  G01S15/894 ,  G01S15/8963 ,  G01S15/8979 ,  G01S15/8993 ,  G10K11/341 ,  Y10S128/916

摘要： An ultrasonic imaging method and apparatus are described for imaging the coronary arteries of the heart. The vascular system is infused with an ultrasonic contrast agent. A volumetric region of the heart wall including a coronary artery is three dimensionally scanned. A projection image of the volumetric region is produced from the scanning, providing a two dimensional contrast image of the coronary artery with the appearance of an angiogram. Preferably the coronary artery signals are segmented from contrast signals emanating from the myocardium and the heart blood pool so that the coronary arteries are clearly highlighted and distinct in the ultrasonic angiogram.

摘要翻译： 描述了用于对心脏的冠状动脉成像的超声成像方法和装置。 血管系统注入超声造影剂。 包括冠状动脉的心壁的体积区域被三维扫描。 从扫描产生体积区域的投影图像，提供冠状动脉的二维造影图像和血管造影图像的外观。 优选地，冠状动脉信号从从心肌和心脏血池发出的对比信号分段，使得冠状动脉在超声波血管造影中被清楚地突出显示和不同。

公开(公告)号：US5879303A

公开(公告)日：1999-03-09

申请号：US943546

申请日：1997-10-03

申请人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang

发明人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang

IPC分类号： A61B8/08 ,  A61B8/14 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC分类号： G01S7/52038 ,  A61B8/08 ,  A61B8/14 ,  A61B8/463 ,  A61B8/488 ,  G01S15/895 ,  G01S7/52026 ,  G01S7/52036 ,  G01S7/52046 ,  G01S7/52077 ,  G01S15/8979 ,  G01S15/8993 ,  G01S7/52033 ,  G01S7/5206 ,  G01S7/52074

摘要： An ultrasonic diagnostic imaging system and methods are described which produces ultrasonic images from harmonic echo components of a transmitted fundamental frequency. Preferably, a programmable digital filter is used to pass harmonic echo components for image processing to the exclusion of fundamental frequency signals. In a preferred embodiment, artifacts are removed by producing decorrelated replicas of the harmonic signals, which are then combined and used for imaging. To produce an image in the presence of depth dependent attenuation of high frequency echo signals, both fundamental and harmonic echo signals are processed and used to produce an image blended from components of both fundamental and harmonic echo signals.

摘要翻译： 描述了从发射的基频的谐波回波分量产生超声波图像的超声诊断成像系统和方法。 优选地，可编程数字滤波器用于将用于图像处理的谐波回波分量传送到排除基频信号。 在优选实施例中，通过产生谐波信号的去相关副本来去除伪影，然后将它们组合并用于成像。 为了在高频回波信号存在深度相关衰减的情况下产生图像，基波和谐波回波信号被处理并用于产生从基波和谐波回波信号的分量混合的图像。

公开(公告)号：US06468216B1

公开(公告)日：2002-10-22

申请号：US09645872

申请日：2000-08-24

申请人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick René Pesque

发明人： Jeffry E. Powers ,  Michalakis Averkiou ,  Matthew Bruce ,  Danny M. Skyba ,  Robert R. Entrekin ,  John D. Fraser ,  Clifford R. Cooley ,  Brent Stephen Robinson ,  David N. Roundhill ,  Gary Allen Schwartz ,  Patrick René Pesque

IPC分类号： A61B800

CPC分类号： A61B8/483 ,  A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/4472 ,  A61B8/481 ,  A61B8/543 ,  G01S7/52025 ,  G01S7/52074 ,  G01S7/5208 ,  G01S7/52095 ,  G01S15/8918 ,  G01S15/8925 ,  G01S15/894 ,  G01S15/8963 ,  G01S15/8979 ,  G01S15/8993 ,  G10K11/341 ,  Y10S128/916

摘要： An ultrasonic imaging method and apparatus are described for imaging the coronary arteries of the heart. The vascular system is infused with an ultrasonic contrast agent. A volumetric region of the heart wall including a coronary artery is three dimensionally scanned. A projection image of the volumetric region is produced from the scanning, providing a two dimensional contrast image of the coronary artery with the appearance of an angiogram. Preferably the coronary artery signals are segmented from contrast signals emanating from the myocardium and the heart blood pool so that the coronary arteries are clearly highlighted and distinct in the ultrasonic angiogram.

摘要翻译： 描述了用于对心脏的冠状动脉成像的超声成像方法和装置。 血管系统注入超声造影剂。 包括冠状动脉的心壁的体积区域被三维扫描。 从扫描产生体积区域的投影图像，提供冠状动脉的二维造影图像和血管造影图像的外观。 优选地，冠状动脉信号从从心肌和心脏血池发出的对比信号分段，使得冠状动脉在超声波血管造影中被清楚地突出显示和不同。

公开(公告)号：US06458083B1

公开(公告)日：2002-10-01

申请号：US09518348

申请日：2000-03-03

申请人： James R. Jago ,  David N. Roundhill ,  Jeffry E. Powers ,  Michalakis Averkiou

发明人： James R. Jago ,  David N. Roundhill ,  Jeffry E. Powers ,  Michalakis Averkiou

IPC分类号： A61B800

CPC分类号： G01S7/52046 ,  A61B8/08 ,  A61B8/14 ,  A61B8/488 ,  G01S7/52026 ,  G01S7/52033 ,  G01S7/52036 ,  G01S7/52038 ,  G01S7/5206 ,  G01S7/52074 ,  G01S15/8979 ,  G01S15/8993

摘要： An ultrasonic diagnostic imaging system receives fundamental frequency, harmonic contrast, and tissue harmonic echo information for image processing. The fundamental and harmonic signal content of the echo information is analyzed and the relative content of an output signal is adjusted as necessary to take advantage of the different characteristics of the different types of echo information present in the echo signal. The ultrasound system can produce images which are an adaptive blend of fundamental, tissue harmonic and harmonic contrast echo information.

摘要翻译： 超声波诊断成像系统接收基频，谐波对比度和图像处理的组织谐波回波信息。 分析回波信息的基波和谐波信号内容，并根据需要调整输出信号的相对内容，以利用回波信号中存在的不同类型的回波信息的不同特性。 超声系统可以产生基本，组织谐波和谐波对比回波信息的自适应混合图像。

公开(公告)号：US06251074B1

公开(公告)日：2001-06-26

申请号：US09440779

申请日：1999-11-16

申请人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang ,  Jeremy D. Wiggins

发明人： Michalakis Averkiou ,  Jeffry E. Powers ,  Peter N. Burns ,  David N. Roundhill ,  Juin-Jet Hwang ,  Jeremy D. Wiggins

IPC分类号： A61B800

CPC分类号： G01S15/895 ,  A61B8/08 ,  A61B8/14 ,  A61B8/463 ,  A61B8/488 ,  G01S7/52026 ,  G01S7/52033 ,  G01S7/52036 ,  G01S7/52038 ,  G01S7/52046 ,  G01S7/5206 ,  G01S7/52074 ,  G01S7/52077 ,  G01S15/8979 ,  G01S15/8993

摘要： An ultrasonic diagnostic imaging system and methods are described which produce tissue harmonic ultrasonic images from harmonic echo components of a transmitted fundamental frequency. Fundamental frequency waves are transmitted by an array transducer to focus at a focal depth. As the transmitted waves penetrate the body, the harmonic effect develops as the wave components begin to focus. The harmonic response from the tissue is detected and displayed, while clutter from the fundamental response is reduced by excluding fundamental frequencies. The technique is especially useful for imaging the endocardial tissue of the heart.

摘要翻译： 描述了从发射的基频的谐波回波分量产生组织谐波超声图像的超声诊断成像系统和方法。 基波频率由阵列传感器传输，以聚焦于焦深。 随着透射波穿透身体，谐波效应随波分量开始集中发展。 检测并显示来自组织的谐波响应，同时通过排除基本频率来减小基波响应的杂波。 该技术对于心脏心内膜的成像特别有用。

公开(公告)号：US20080228075A1

公开(公告)日：2008-09-18

申请号：US12064309

申请日：2006-08-25

申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

IPC分类号： A61B8/00

CPC分类号： A61B17/22004 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B17/2256 ,  A61B2017/22028 ,  A61B2090/378 ,  G01S15/8918 ,  G01S15/8977

摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

摘要翻译： 组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。 治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。

公开(公告)号：US06540684B2

公开(公告)日：2003-04-01

申请号：US10007287

申请日：2001-11-08

申请人： Michalakis Averkiou ,  Matthew Bruce ,  Jeffry E. Powers

发明人： Michalakis Averkiou ,  Matthew Bruce ,  Jeffry E. Powers

IPC分类号： A61B806

CPC分类号： A61B8/481 ,  A61B5/0456 ,  A61B5/7239 ,  A61B8/06 ,  A61B8/08 ,  A61B8/13 ,  A61B8/463 ,  A61B8/483 ,  A61B8/488 ,  A61B8/543 ,  A61K49/223 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52039 ,  G01S7/52041 ,  G01S15/8959 ,  G01S15/8963 ,  G01S15/8993

摘要： Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.