公开(公告)号：US6129687A

公开(公告)日：2000-10-10

申请号：US916111

申请日：1997-08-21

申请人： David Powell ,  Joseph H. Munning

发明人： David Powell ,  Joseph H. Munning

IPC分类号： A61H15/00 ,  A61H15/02 ,  B65D8/10 ,  B65D8/12 ,  B65D6/16 ,  B65D6/28 ,  B65D21/08

CPC分类号： A61H15/02 ,  A61H15/0092 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/0242 ,  A61H2201/0257 ,  A61H2201/0264

摘要： A rollable massaging device that simultaneously provides both hot and cold therapy is disclosed. The massaging device includes a first cylindrical container defining a first opening and a first longitudinal axis therethrough, and a second cylindrical container defining a second opening and a second longitudinal axis therethrough. The device includes a coupling that releasably and resealably engages said first and second opening. The first container is preferably filled with a hot liquid and the second container is preferably filled with a cold liquid, which are separated by a wall defined by the coupling. The outer surface of each container define any of a number of various surface profiles for massage therapy, such as a plurality of protusions, dimples, ridges, or ribs. In one alternative embodiment, the walls of the first and second containers may be adjustable in length to conform to the size of area to be massaged. In another embodiment, the first and second container also define first and second bottoms opposite the first and second openings to which the containers may be joined.

摘要翻译： 公开了同时提供冷热治疗的可滚动按摩装置。 按摩装置包括限定第一开口和穿过其的第一纵向轴线的第一圆柱形容器，以及限定第二开口和穿过其的第二纵向轴线的第二圆柱形容器。 该装置包括可释放地且可重新密封地接合所述第一和第二开口的联接件。 第一容器优选地填充有热液体，并且第二容器优选地填充有冷液体，冷液体由耦合器限定的壁分隔开。 每个容器的外表面限定用于按摩治疗的多个各种表面轮廓中的任何一个，例如多个突起，凹坑，脊或肋。 在一个替代实施例中，第一和第二容器的壁可以在长度上可调节以符合待按摩面积的大小。 在另一个实施例中，第一和第二容器还限定与容器可以连接的第一和第二开口相对的第一和第二底部。

公开(公告)号：US20120094555A1

公开(公告)日：2012-04-19

申请号：US13260428

申请日：2010-03-26

申请人： Stuart Calverley ,  David Powell

发明人： Stuart Calverley ,  David Powell

IPC分类号： B63H23/24 ,  H02K51/00

CPC分类号： B63H23/24 ,  B63H2005/1258 ,  B63H2021/202 ,  H02K7/11 ,  H02K51/00 ,  Y02T70/5236

摘要： A propulsion device for a marine vessel, the propulsion device comprising an electrical machine with integral magnetic gearing, which comprises three members, namely a first or inner rotor comprising a first plurality of permanent magnets, a second rotor in the form of a plurality of ferromagnetic pole pieces, and a stator which is associated with a plurality of 3-phase windings and to the periphery of which a plurality of second permanent magnets are fixed. The magnetic pole piece rotor is connected to a drive shaft provided with a propulsion means for providing propulsion to the marine vessel. The first or inner rotor is free to rotate about the drive shaft. The pole pieces of the second rotor are arranged to magnetically couple the permanent magnets of the first or inner rotor to the second permanent magnets on the stator.

摘要翻译： 一种用于海洋船舶的推进装置，该推进装置包括具有整体磁力传动装置的电机，其包括三个构件，即包括第一多个永磁体的第一或第二转子，包括多个铁磁体形式的第二转子 极片和与多个三相绕组相关联的定子，并且固定有多个第二永磁体的周边。 磁极片转子连接到设置有用于向船舶提供推进的推进装置的驱动轴上。 第一或内转子围绕驱动轴自由旋转。 第二转子的极片布置成将第一或内转子的永磁体磁耦合到定子上的第二永磁体。

公开(公告)号：US20100105639A1

公开(公告)日：2010-04-29

申请号：US12639645

申请日：2009-12-16

申请人： Yves Dumoulin ,  Carl Gauthier ,  David Powell ,  Hugues Moreau

发明人： Yves Dumoulin ,  Carl Gauthier ,  David Powell ,  Hugues Moreau

IPC分类号： A61K31/606 ,  A61P1/00

CPC分类号： A61K9/14 ,  A61K9/0031 ,  A61K9/02 ,  A61K31/136 ,  A61K31/195 ,  A61K31/606 ,  A61K47/44

摘要： The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP ) and a hard fat having an ascending melting point of 32 to 35.5° C. Yet another embodiment is a mesalamine rectal suppository comprising mesalamine particles and one or more pharmaceutically acceptable excipients, where the mesalamine particles have a surface area of from about 0.1 m2/g to about 2.8 m2/g (e.g., from about 0.1 m2/g to about 1.3 m2/g). Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5.

摘要翻译： 本发明涉及美沙拉坦直肠栓剂，其旨在提供改善的使用舒适性。 本发明的一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的药物负载范围为35％至50％。 本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含振荡密度范围为约600至约800g / L的美沙拉嗪（通过USP <616>测量）和具有上升熔点为32至35.5°的硬脂肪 C.另一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪颗粒和一种或多种药学上可接受的赋形剂，其中美沙拉嗪颗粒的表面积为约0.1m 2 / g至约2.8m 2 / g（例如，约0.1m 2 / g至约1.3m 2 / g）。 还提供了制备方法和美沙拉坦栓剂的治疗方法。 本发明还提供了一种通过用USP装置＃2在40℃下测量溶解参数（例如溶解度）来测定美沙拉嗪直肠栓剂如1g美沙胺栓剂的溶出参数（如溶出速率），并且桨叶转速 在pH 7.5的0.2M磷酸盐缓冲液中的125rpm。

公开(公告)号：US20100057855A1

公开(公告)日：2010-03-04

申请号：US12199235

申请日：2008-08-27

申请人： Al Chakra ,  Brian Hussey ,  Simon P. O'Doherty ,  David Powell

发明人： Al Chakra ,  Brian Hussey ,  Simon P. O'Doherty ,  David Powell

IPC分类号： G06F15/16 ,  G06F17/30

CPC分类号： H04L51/00

摘要： Methods, systems, and computer readable media for tracking subject matter of an e-mail discussion are described. A query e-mail is received, wherein the query e-mail includes an initial request and wherein the query e-mail commences the e-mail discussion. At least one marked response e-mail is received, wherein the at least one marked response e-mail includes information responsive to the query e-mail and is marked with an indication that the initial request has been resolved, and wherein the at least one marked response e-mail is appended to the e-mail discussion. At least one visual indicator in the e-mail discussion is provided that distinguishes at least one of the query e-mail and the at least one marked response e-mail when the e-mail discussion is opened at a later time.

摘要翻译： 描述用于跟踪电子邮件讨论主题的方法，系统和计算机可读介质。 接收查询电子邮件，其中查询电子邮件包括初始请求，其中查询电子邮件开始电子邮件讨论。 接收至少一个标记的响应电子邮件，其中所述至少一个标记的响应电子邮件包括响应于查询电子邮件的信息，并且标记有初始请求已被解析的指示，并且其中所述至少一个 标有回应的电子邮件附加到电子邮件讨论中。 提供了电子邮件讨论中的至少一个视觉指示符，其在稍后打开电子邮件讨论时区分查询电子邮件和至少一个标记的回复电子邮件中的至少一个。

公开(公告)号：US20090264386A1

公开(公告)日：2009-10-22

申请号：US12476185

申请日：2009-06-01

申请人： Carl Gauthier ,  Yves Dumoulin ,  David Powell

发明人： Carl Gauthier ,  Yves Dumoulin ,  David Powell

IPC分类号： A61K31/606 ,  A61P1/00

CPC分类号： A61K9/02 ,  A61K31/137 ,  A61K47/44 ,  Y10S514/953

摘要： The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 400 to about 600 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 870 to about 1715 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP ) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5.

摘要翻译： 本发明涉及美沙拉坦直肠栓剂，其旨在提供改善的使用舒适性。 本发明的一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的药物负载范围为35％至50％。 本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含约850至约1150mg美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的总重量为约2250至约2700mg。 本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含约400至约600mg的美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的总重量为约870至约1715mg。 本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含振荡密度范围为约600至约800g / L的美沙拉嗪（通过USP <616>测量）和具有上升熔点为32至35.5°的硬脂肪 C.还提供了制备方法和美沙拉嗪栓剂的治疗方法。 本发明还提供了一种通过用USP装置＃2在40℃下测量溶解参数（例如溶解度）来测定美沙拉嗪直肠栓剂如1g美沙胺栓剂的溶出参数（如溶出速率），并且桨叶转速 在pH 7.5的0.2M磷酸盐缓冲液中的125rpm。

公开(公告)号：US20090056095A1

公开(公告)日：2009-03-05

申请号：US12263931

申请日：2008-11-03

申请人： David Powell ,  Steven R. Watts

发明人： David Powell ,  Steven R. Watts

IPC分类号： E04H17/26 ,  E04H17/24 ,  B25B27/00

CPC分类号： E04H17/26 ,  E04H17/1413 ,  E04H2017/1469 ,  Y10T29/53683 ,  Y10T29/53909 ,  Y10T29/53943

摘要： A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.

摘要翻译： 轨道牵引器，其允许移除与栅栏柱接合的围栏栏杆，所述围栏栏杆包括具有第一端和第二端的叶片。 叶片的第一端具有允许插入到其中插入有导轨的栅栏柱槽中的厚度和宽度。 导轨具有自锁片，必须按下以将轨从栅栏柱槽中取出。 围栏轨道牵开器还具有附接到叶片第二端的把手。 在从所述围栏柱槽移除所述导轨期间，所述手柄允许施加抵抗手柄的力将所述把手的位置固定在所述挡板柱上。 当不使用时，手柄也可用于承载轨道牵引器。 轨道牵引器的手柄可以被配置成允许与叶片的一体化。 手柄也可以被配置成允许一对轨道护栏卷收器在不使用时装配或卡扣在一起。

公开(公告)号：US20080111118A1

公开(公告)日：2008-05-15

申请号：US11599945

申请日：2006-11-15

申请人： David Powell ,  Steven R. Watts

发明人： David Powell ,  Steven R. Watts

IPC分类号： E04H17/26

CPC分类号： E04H17/26 ,  E04H17/1413 ,  E04H2017/1469 ,  Y10T29/53683 ,  Y10T29/53909 ,  Y10T29/53943

摘要： A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.

摘要翻译： 轨道牵引器，其允许移除与栅栏柱接合的围栏栏杆，所述围栏栏杆包括具有第一端和第二端的叶片。 叶片的第一端具有允许插入到其中插入有导轨的栅栏柱槽中的厚度和宽度。 导轨具有自锁片，必须按下以将轨从栅栏柱槽中取出。 围栏轨道牵开器还具有附接到叶片第二端的把手。 在从所述围栏柱槽移除所述导轨期间，所述手柄允许施加抵抗手柄的力将所述把手的位置固定在所述挡板柱上。 当不使用时，手柄也可用于承载轨道牵引器。 轨道牵引器的手柄可以被配置成允许与叶片的一体化。 手柄也可以被配置成允许一对轨道护栏卷收器在不使用时装配或卡扣在一起。

公开(公告)号：US20070072807A1

公开(公告)日：2007-03-29

申请号：US11523281

申请日：2006-09-19

申请人： Gary Christie ,  Ishrut Hussain ,  David Powell

发明人： Gary Christie ,  Ishrut Hussain ,  David Powell

IPC分类号： A61K38/10 ,  C12Q1/37

CPC分类号： C12N9/6478 ,  A61K38/10 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2333/96472 ,  G01N2500/02

摘要： A method of screening compounds to identify those compounds which inhibit the Asp 1 mediated cleavage of a polypeptide or protein substrate, the method comprising: providing a reaction system comprising Asp 1 and substrate; and measuring the extent of cleavage of the substrate in the presence of test compound as compared with the extent of cleavage in the absence of test compound, and compounds identified thereby as well as compounds which are inhibitors of Asp 1 modulated APP cleavage and their use in therapy including the treatment or prophylaxis of β amyloid protein-related disease including AD.

摘要翻译： 一种筛选化合物以鉴定抑制Asp1介导的多肽或蛋白质底物切割的化合物的方法，所述方法包括：提供包含Asp 1和底物的反应体系; 并且在不存在测试化合物的情况下测量在测试化合物存在下底物的切割程度，以及由此鉴定的化合物以及作为Asp 1调节的APP切割抑制剂的化合物及其在 治疗包括治疗或预防β淀粉样蛋白相关疾病，包括AD。

公开(公告)号：US20060286484A1

公开(公告)日：2006-12-21

申请号：US11445902

申请日：2006-06-02

申请人： David Powell ,  Ahmad Naiini ,  N. Metivier ,  Il'ya Rushkin ,  Richard Hopla

发明人： David Powell ,  Ahmad Naiini ,  N. Metivier ,  Il'ya Rushkin ,  Richard Hopla

IPC分类号： C07F7/18 ,  C04B41/49 ,  C09D183/04 ,  C04B28/36 ,  C01B25/00 ,  C08J5/12

CPC分类号： G03F7/11 ,  G03F7/0046 ,  G03F7/023 ,  G03F7/0233 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/0751 ,  Y10T428/12528

摘要： A pretreatment composition of: (a) at least one compound having structure VI V1—Y—V2  VI wherein Y is selected from the group consisting of S, O, NR2, (HOCH)p, and each R1 is independently selected from H, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group or a halogen, each R2 is independently H, SH, CH3, C2H5, and a linear or branched C1-C4 alkyl group containing a thiol group; and wherein V1 and V2 are independently selected from wherein, m is independently an integer from 0 to 4 with the proviso that m can =0 only when Y═ n is an integer from 1 to 5; p is an integer of from 1 to 4, and each R1 is defined as above; (b) at least one organic solvent, and optionally, (c) at least one adhesion promoter; wherein the amount of the compound of Structure VI present in the composition is effective to inhibit residue from forming when the photosensitive composition is coated on a substrate and the coated substrate is processed to form an image thereon.

摘要翻译： 一种预处理组合物，其特征在于：（a）至少一种具有结构VI的化合物<？in-line-formula description =“In-line Formulas”end =“lead”→> V > 2 在线公式描述=“在线公式”end =“tail”？>其中Y选自S，O，NR 2 >，（HOCH）p ，每个R 1独立地选自H，烷基，烯基，炔基，烷氧基或卤素， 每个R 2独立地为H，SH，CH 3，C 2 H 5，以及直链或支链 含有硫醇基的C 1 -C 4烷基; 并且其中V 1和V 2独立地选自其中，m独立地为0至4的整数，条件是仅当Y-n为 1到5的整数; p为1〜4的整数，每个R 1如上定义; （b）至少一种有机溶剂，和任选地（c）至少一种粘合促进剂; 其中组合物中存在的结构VI化合物的量在将感光组合物涂布在基材上时有效地抑制残留物的形成，并且将涂覆的基材加工成在其上形成图像。

公开(公告)号：US20060216641A1

公开(公告)日：2006-09-28

申请号：US11386471

申请日：2006-03-22

申请人： Ahmad Naiini ,  David Powell ,  N. Metivier ,  Donald Perry

发明人： Ahmad Naiini ,  David Powell ,  N. Metivier ,  Donald Perry

IPC分类号： G03C1/00

CPC分类号： G03F7/023 ,  G03F7/0046 ,  G03F7/022 ,  G03F7/0233 ,  G03F7/038 ,  G03F7/0382 ,  G03F7/039 ,  G03F7/0751 ,  G03F7/085

摘要： A photosensitive resin composition comprising: (a) at least one polybenzoxazole precursor polymer; (b) at least one compound having Structure VI wherein, V is CH or N, Y is O or NR3 wherein R3 is H, CH3 or C2H5, R1 and R2 each independently are H, C1-C4 alkyl group, C1-C4 alkoxy group, cyclopentyl or cyclohexyl, or alternatively, R1 and R2 can be fused to produce a substituted or unsubstituted benzene ring; and (c) at least one solvent; wherein the amount of the compound of Structure VI present in the composition is effective to inhibit residue from forming when the composition is coated on a substrate and the coated substrate is subsequently processed to form an image on the substrate, and with the proviso that if the polybenzoxazole precursor polymer solely consists of polybenzoxazole precursor polymers that do not contain a photoactive moiety in the polymer, then (d) at least one photoactive compound is also present in the composition. The present invention also concerns a process for forming a relief pattern and electronic parts using the composition.

摘要翻译： 一种光敏树脂组合物，其包含：（a）至少一种聚苯并恶唑前体聚合物; （b）至少一种具有结构VI的化合物，其中V是CH或N，Y是O或NR 3，其中R 3是H，CH 3， 或/或C 2 H 5，R 1和R 2各自独立地为H，C _{1和R 2'稠合以产生取代或未取代的苯环; 和（c）至少一种溶剂; 其中组合物中存在的结构VI化合物的量有效地抑制当组合物涂覆在基材上时残留物形成，并且随后处理涂覆的基材以在基材上形成图像，条件是如果 聚苯并恶唑前体聚合物仅由在聚合物中不含光活性部分的聚苯并恶唑前体聚合物组成，则（d）组合物中也存在至少一种光活性化合物。 本发明还涉及使用该组合物形成浮雕图案和电子部件的方法。}