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公开(公告)号：US20180313805A1
公开(公告)日：2018-11-01
申请号：US15497501
申请日：2017-04-26
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Joe Fox , Terrece Pearman
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Joe Fox , Terrece Pearman
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition has decayed in response to environmental conditions and time. The taggants may decay in response to environmental conditions which cause drugs to lose their efficacy. The decay may occur due to improper storage or excursions into certain environmental conditions. These environmental conditions may include light, temperature, moisture, oxidation, and age. By including taggants that have different decay characteristics, the environmental condition that caused the decay may be determined. The amount of time the drug composition was exposed to the environmental condition and the amount of effective drug remaining may also be determined. The disclosed method may reduce the need for a unique assay for each drug to assess decay and determine shelf life. The disclosed method may also be used as a quality control technique for pharmaceutical products.
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公开(公告)号：US20180306826A1
公开(公告)日：2018-10-25
申请号：US15496407
申请日：2017-04-25
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
CPC分类号： G01N33/94 , A47K17/00 , A61B5/15 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0061 , A61B2010/0077 , A61B2010/0087 , G01N33/15 , G01N33/493 , G01N2458/00
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US20180335427A1
公开(公告)日：2018-11-22
申请号：US15601532
申请日：2017-05-22
申请人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/94
摘要： We disclose a tag for tracking and identifying pharmaceutical and nutritional products. The tag includes a paramagnetic microparticle which is connected to at least one unique and detectable chemical. The chemical may be coated on the paramagnetic microparticle or connected through functional groups. The tags may be too large to be taken into the bloodstream and therefore remain in the user's gastrointestinal tract. The tags may be fully or partially isolated from feces for analysis. The tags are attracted to an external electromagnetic force but are not magnetically attracted to each other. Consequently, the tags are safe to ingest. The tags may vary in volume or mass so as to be separable according to mass. The tags may be non-spherical in shape thus increasing the surface area to volume ratio and increasing the amount of chemical which may be attached as a taggant.
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公开(公告)号：US20180306825A1
公开(公告)日：2018-10-25
申请号：US15494089
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
CPC分类号： G01N33/94 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0061 , A61B2010/0077 , G01N33/15 , G01N33/493 , G01N33/58
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US20180321218A1
公开(公告)日：2018-11-08
申请号：US15589403
申请日：2017-05-08
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/493 , G01N33/53 , G01N33/487 , G01N33/543 , G01N33/542 , G01N27/327 , G01N21/64 , G01N21/78 , A61B5/00 , A61B5/20
CPC分类号： G01N33/493 , A61B5/0071 , A61B5/207 , G01N21/6428 , G01N21/78 , G01N27/3276 , G01N33/48792 , G01N33/5308 , G01N33/542 , G01N33/5438 , G01N2021/6417 , G01N2021/6432 , G01N2021/6439
摘要： We disclose an in-toilet urinalysis system which includes a system for collection urine and for analysis of urine components using aptamer technology. Urine collection system may dispense urine into cuvettes, channels, or other containers that include aptamers. The aptamers may detect target molecules in urine. The aptamers may measure urine analytes, detect excreted drugs or drug metabolites, or disease markers. Upon binding to the target molecule, the aptamers may produce a signal which a sensor in the toilet may detect. In some embodiments, the signal may be electrochemical, fluorescent, or colorimetric. The measurements obtained from analysis of the urine may be used to assess a user's health or diagnose disease. In some embodiments, the measurements are stored in a controller which may transmit the measurements to a healthcare provider for assessment.
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公开(公告)号：US20180306824A1
公开(公告)日：2018-10-25
申请号：US15493433
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J.M. Butala
发明人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J.M. Butala
IPC分类号： G01N33/94 , A61B5/15 , A61B10/00 , G01N21/359
CPC分类号： G01N21/359 , A61B5/145 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0009 , A61B2010/0061 , A61B2010/0077 , A61B2010/0087 , G01N30/02 , G01N33/15 , G01N2458/15
摘要： We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
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公开(公告)号：US10408849B2
公开(公告)日：2019-09-10
申请号：US15494089
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US10444144B2
公开(公告)日：2019-10-15
申请号：US15493433
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J. M. Butala
发明人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J. M. Butala
IPC分类号： G01N21/359 , A61B10/00 , G01N33/15 , A61B5/145 , G01N30/02
摘要： We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
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公开(公告)号：US10209264B2
公开(公告)日：2019-02-19
申请号：US15496407
申请日：2017-04-25
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/94 , G01N33/493 , G01N33/15 , A61B5/15 , A61G10/00 , A47K17/00 , A61B10/00 , G01N33/58
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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10.发明申请公开(公告)号：US20180334669A1
公开(公告)日：2018-11-22
申请号：US15597633
申请日：2017-05-17
申请人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox
发明人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox
IPC分类号： C12N15/10
CPC分类号： C12N15/1065
摘要： We disclose a method of tagging a variety of pharmaceutical or nutritional products in which well-studied chemicals may be added to the products in unique ratios. The identities of the chemicals and their relative ratios comprise unique taggants. The taggants may identify which of multiple distinct categories the product falls within. The method includes the step of systematically varying the relative concentrations of the chemicals resulting in multiple ratios of the chemicals. The plurality of ratios of a defined set of chemicals may be collected to form a library of taggants associated with specified items or categories. As the number of chemicals added per product increases, the library supports more categories and the system is less likely to produce a false positive. The method may result in a series of taggants for each item which is single fault tolerant or double fault tolerant.
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