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    Tandem ion modulator for characterizing larger biomolecules in a differential mobility spectrometer
    1.
    发明授权
    Tandem ion modulator for characterizing larger biomolecules in a differential mobility spectrometer 有权

    公开(公告)号：US10203305B1

    公开(公告)日：2019-02-12

    申请号：US15659945

    申请日：2017-07-26

    申请人： David R. Hall ,  Dan Allen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Joe Fox

    IPC分类号： G01N27/62 ,  H01J49/00

    摘要： The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes multiple ion-bunching electrodes, each with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrodes produce each a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.

    ION MODULATOR FOR CHARACTERIZING LARGER BIOMOLECULES IN A DIFFERENTIAL MOBILITY SPECTROMETER
    2.
    发明申请
    ION MODULATOR FOR CHARACTERIZING LARGER BIOMOLECULES IN A DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开

    公开(公告)号：US20180374693A1

    公开(公告)日：2018-12-27

    申请号：US15632636

    申请日：2017-06-26

    申请人： David R. Hall ,  Dan Allen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Joe Fox

    IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/04 ,  G01N27/62

    摘要： The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes an ion-bunching electrode with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrode produces a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument is more compact than a larger traditional ion mobility spectrometer and does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.

    Urinalysis cassette and system
    5.
    发明授权
    Urinalysis cassette and system 有权

    公开(公告)号：US09810686B1

    公开(公告)日：2017-11-07

    申请号：US15265144

    申请日：2016-09-14

    申请人： David R. Hall ,  Dan Allen ,  Joshua Larsen ,  Ben Swenson ,  Jared Reynolds ,  Joe Fox ,  Lloyd J. Wilson

    发明人： David R. Hall ,  Dan Allen ,  Joshua Larsen ,  Ben Swenson ,  Jared Reynolds ,  Joe Fox ,  Lloyd J. Wilson

    IPC分类号： G01N21/00 ,  G01N33/52 ,  A61B5/20 ,  A61B5/00 ,  A61B10/00

    CPC分类号： G01N33/521 ,  A61B5/207 ,  A61B5/6891 ,  A61B5/742 ,  A61B10/007

    摘要： A urinalysis cassette and system that includes a toilet, into which a urinalysis cassette is inserted. The cassette is comprised of a roll of color-change-reagent strips. Each strip includes a plurality of strip sections wherein an absorbent material is imbued with color-change reagent, or onto which one or more color-change reagents are dispensed. The color-change-reagent strips are consecutive and contiguous on the roll. A cassette includes two spools arranged such that when the spools turn, the reagent strip moves from a first (source spool) to a second (waste spool). The section of the reagent strip that is between the two spools may be exposed to a urine specimen. The absorbent-material strips that have been exposed to both a urine specimen and a color-change reagent may undergo a chemical reaction. Selective-lighting illumination may be applied to absorbent-material strips that have undergone such chemical reactions to measure reflectivity of certain color wavelengths. This measurement may be expressed in terms of a digital readout, which may be displayed on a user interface.

    Helical Drain For A Toilet
    7.
    发明申请
    Helical Drain For A Toilet 审中-公开

    公开(公告)号：US20170198466A1

    公开(公告)日：2017-07-13

    申请号：US15168664

    申请日：2016-05-31

    申请人： David R. Hall ,  Dan Allen ,  Jared Reynolds ,  Joshua Larsen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Jared Reynolds ,  Joshua Larsen ,  Joe Fox

    IPC分类号： E03D11/06

    CPC分类号： E03D11/06 ,  A61B10/0038 ,  E03D11/18 ,  E03D2201/30

    摘要： A helical drain for a toilet is disclosed. The present invention relates to a novel toilet drain configuration. Specifically, the novel toilet drain configuration comprises a helical loop trapway. The drain of the present invention exits the toilet bowl and forms a substantially vertical tubular loop running generally parallel to the width of the bowl or stool, or perpendicular to the longitudinal axis of the bowl or stool, before being connected to a sewer. The drain of the present invention functions like a P-trap syphon in removing the contents of the bowl. The diameter of the looped tubular portion of the drain may vary by approximately 20 percent or less in the direction of the sewer connection. Sensors may be placed on the drain to monitor drain contents, fluid levels, and drain performance. The drain may be fitted with valves to control the flow of fluids and gases through the drain.

    Ion modulator for characterizing larger biomolecules in a differential mobility spectrometer
    10.
    发明授权
    Ion modulator for characterizing larger biomolecules in a differential mobility spectrometer 有权

    公开(公告)号：US10163614B1

    公开(公告)日：2018-12-25

    申请号：US15632636

    申请日：2017-06-26

    申请人： David R. Hall ,  Dan Allen ,  Joe Fox

    发明人： David R. Hall ,  Dan Allen ,  Joe Fox

    IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/04 ,  G01N27/62

    摘要： The tandem differential mobility spectrometer (DMS)-ion modulator instrument provides improved resolution relative to traditional DMS for molecules with larger masses. The instrument includes an ion-bunching electrode with an AC field synchronized to the transit time of the ion flow which is positioned downstream of a DMS. The ion bunching electrode produces a mobility-dependent modulation of the ion current. The ratio of AC to DC current provides a measure of the mobility of a large ion, even if it has little differential mobility, thereby extending the useful range of mobility characterization of a DMS system. The instrument is more compact than a larger traditional ion mobility spectrometer and does not require high voltages or high frequencies. Modulation before DMS separation or between tandem DMS separations produces a variable range of analyte and reactant ion densities as well as spatially separating negative and positive ions to reduce ion recombination.