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    IDENTIFICATION OF ABERRANT MEASUREMENTS OF IN VIVO GLUCOSE CONCENTRATION USING TEMPERATURE
    1.
    发明申请
    IDENTIFICATION OF ABERRANT MEASUREMENTS OF IN VIVO GLUCOSE CONCENTRATION USING TEMPERATURE 审中-公开
    使用温度鉴定葡萄糖浓度的测定

    公开(公告)号：US20110152658A1

    公开(公告)日：2011-06-23

    申请号：US12972385

    申请日：2010-12-17

    申请人： Thomas A. Peyser ,  Richard E. Purvis ,  David R. Markle ,  Soya Gamsey ,  Matthew A. Romey

    发明人： Thomas A. Peyser ,  Richard E. Purvis ,  David R. Markle ,  Soya Gamsey ,  Matthew A. Romey

    IPC分类号： A61B5/145

    CPC分类号： A61B5/1473 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7239 ,  A61B2560/0252 ,  A61B2562/0271

    摘要： Disclosed herein are methods and systems for generating an estimate of an in vivo analyte concentration and identifying whether the estimate is aberrant. In some embodiments, the system includes a sensor comprising an analyte sensor and a temperature sensing element, and a control unit programmed to identify changes in temperature that may indicate a non-physiologic condition (and result in an aberrant glucose measurement). In some embodiments, the methods include generating an estimate of analyte concentration at a particular time using the analyte sensor, and generating first and second signals indicative of temperature using the temperature sensing element. In some embodiments the methods include identifying the estimate of analyte concentration as aberrant if the magnitude of the difference between the first and second signals indicative of temperature exceeds a threshold value.

    摘要翻译： 本文公开了用于产生体内分析物浓度的估计并识别估计是否异常的方法和系统。 在一些实施例中，系统包括传感器，其包括分析物传感器和温度感测元件，以及控制单元，被编程为识别可能指示非生理状况（并导致异常葡萄糖测量）的温度变化。 在一些实施方案中，所述方法包括使用分析物传感器在特定时间产生分析物浓度的估计，以及使用温度感测元件产生指示温度的第一和第二信号。 在一些实施方案中，如果指示温度的第一和第二信号之间的差值的大小超过阈值，则所述方法包括将分析物浓度的估计识别为异常。

    MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION
    3.
    发明申请
    MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION 有权
    用于测量分析温度和PH校正的分析仪浓度的测量装置和方法

    公开(公告)号：US20110224516A1

    公开(公告)日：2011-09-15

    申请号：US13046571

    申请日：2011-03-11

    申请人： Matthew A. Romey ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： Matthew A. Romey ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/1455 ,  A61B5/145

    CPC分类号： G06F17/00 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0247 ,  A61B2560/0252 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2021/7793

    摘要： Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.

    摘要翻译： 本文公开了估计分析物浓度的方法，其包括产生指示分析物浓度的信号，产生指示温度的信号，产生指示pH的信号，并且使用下述方程式转化表示分析物浓度的信号： 取决于Michaelis-Menten参数的修改的Michaelis-Menten方程的形式，其中根据包括温度和pH校准参数，指示温度的信号和指示pH的信号的数据来设置Michaelis-Menten参数的值 。 本文还公开了采用上述方法的测量装置。

    Optical sensor configuration for ratiometric correction of blood glucose measurement
    6.
    发明授权
    Optical sensor configuration for ratiometric correction of blood glucose measurement 有权
    血糖测量比例校正的光学传感器配置

    公开(公告)号：US08467843B2

    公开(公告)日：2013-06-18

    申请号：US12612602

    申请日：2009-11-04

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0238 ,  A61B2562/043 ,  G01N21/7703 ,  G01N2021/7786

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于检测血糖的光学传感器。 该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端和无损伤尖端部分之间的间隙内，其中光纤和无创尖端部分通过耦合部件耦合，例如杆或海波管或笼， 差距。 传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT
    7.
    发明申请
    OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT 有权
    用于血糖测量的比例校正的光传感器配置

    公开(公告)号：US20110105866A1

    公开(公告)日：2011-05-05

    申请号：US12612602

    申请日：2009-11-04

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/1459

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0238 ,  A61B2562/043 ,  G01N21/7703 ,  G01N2021/7786

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于检测血糖的光学传感器。 该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端和无损伤尖端部分之间的间隙内，其中光纤和无创尖端部分通过耦合部件耦合，例如杆或海波管或笼， 差距。 传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID
    8.
    发明申请
    OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID 审中-公开
    光学传感器配置和监测间接流体中葡萄糖活性的方法

    公开(公告)号：US20120053427A1

    公开(公告)日：2012-03-01

    申请号：US13221696

    申请日：2011-08-30

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser ,  William Markle

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser ,  William Markle

    IPC分类号： A61B5/1459 ,  A61B5/01

    CPC分类号： A61B5/14532 ,  A61B5/1459

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose by deploying the optical sensor into the interstitial fluid. The sensor comprises a chemical indicator system capable of generating an optical signal related to the blood glucose activity. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose activity, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于通过将光学传感器部署到组织液中来检测血糖的光学传感器。 传感器包括能够产生与血糖活性相关的光学信号的化学指示器系统。 传感器还包括用于产生和检测与血糖活动无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR
    10.
    发明申请
    DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR 审中-公开
    光学分析传感器的部署系统和方法

    公开(公告)号：US20110263953A1

    公开(公告)日：2011-10-27

    申请号：US13095748

    申请日：2011-04-27

    申请人： David R. Markle ,  Soya Gamsey ,  Kenneth J. Chesnin

    发明人： David R. Markle ,  Soya Gamsey ,  Kenneth J. Chesnin

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/1491 ,  A61B5/1495 ,  A61B2560/0252 ,  A61B2560/06

    摘要： Embodiments of the invention are directed to a delivery device and method for deploying an optical analyte sensor. The delivery device comprises hollow tubes configured to operate telescopically. The optical sensor is configured to retract and extend from a distal end of the delivery device, by sliding the telescoping tubes with respect to one another. The delivery device may also have a locking mechanism such that the distal end portion of the sensor will extend to a preset locked position beyond the delivery device, e.g., during calibration and deployment. The device is capable of being used to ship, calibrate, and deploy the sensor while maintaining sterility and avoiding exposure to the external environment.

    摘要翻译： 本发明的实施例涉及用于部署光学分析物传感器的递送装置和方法。 输送装置包括构造成可伸缩地操作的中空管。 光学传感器被配置为通过相对于彼此滑动伸缩管而从输送装置的远端缩回和延伸。 输送装置还可以具有锁定机构，使得传感器的远端部分例如在校准和展开期间将延伸到超出输送装置的预设锁定位置。 该设备能够用于运输，校准和部署传感器，同时保持无菌状态，避免暴露在外部环境中。