公开(公告)号：US06974684B2

公开(公告)日：2005-12-13

申请号：US10211689

申请日：2002-08-01

申请人： David W. Anderson ,  John P. Alsobrook II ,  Ferenc L. Boldog ,  Catherine E. Burgess ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Linda Gorman ,  Xiaojia Sasha Guo ,  Nikolai Khramtsov ,  Denise M. Lepley ,  John R. MacDougall ,  Carol E. A. Pena ,  John A. Peyman ,  Meera Patturajan ,  Daniel K. Rieger ,  Richard A. Shimkets ,  Glennda Smithson ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Mei Zhong

发明人： David W. Anderson ,  John P. Alsobrook II ,  Ferenc L. Boldog ,  Catherine E. Burgess ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Linda Gorman ,  Xiaojia Sasha Guo ,  Nikolai Khramtsov ,  Denise M. Lepley ,  John R. MacDougall ,  Carol E. A. Pena ,  John A. Peyman ,  Meera Patturajan ,  Daniel K. Rieger ,  Richard A. Shimkets ,  Glennda Smithson ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Mei Zhong

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US07034132B2

公开(公告)日：2006-04-25

申请号：US10162335

申请日：2002-06-03

申请人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

发明人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US07108972B2

公开(公告)日：2006-09-19

申请号：US10080334

申请日：2002-02-21

申请人： Carol E. A. Pena ,  Richard A. Shimkets ,  Li Li ,  Suresh G. Shenoy ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Uriel M. Malyankar ,  Xiaojia (Sasha) Guo ,  Vladimir Y. Gusev ,  Stacie J. Casman ,  Ferenc L. Boldog ,  Katarzyna Furtak ,  Velizar T. Tchernev ,  Meera Patturajan ,  Esha A. Gangolli ,  Muralidhara Padigaru ,  Xiaohong Liu ,  Jason C. Baumgartner ,  Valerie Gerlach ,  Steven K. Spaderna ,  Bryan D. Zerhusen

发明人： Carol E. A. Pena ,  Richard A. Shimkets ,  Li Li ,  Suresh G. Shenoy ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Uriel M. Malyankar ,  Xiaojia (Sasha) Guo ,  Vladimir Y. Gusev ,  Stacie J. Casman ,  Ferenc L. Boldog ,  Katarzyna Furtak ,  Velizar T. Tchernev ,  Meera Patturajan ,  Esha A. Gangolli ,  Muralidhara Padigaru ,  Xiaohong Liu ,  Jason C. Baumgartner ,  Valerie Gerlach ,  Steven K. Spaderna ,  Bryan D. Zerhusen

IPC分类号： C12Q1/68

CPC分类号： G05B19/408 ,  A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US07253266B2

公开(公告)日：2007-08-07

申请号：US10174394

申请日：2002-06-17

申请人： Richard A. Shimkets ,  Michael Jeffers ,  Sudhirdas K. Prayaga ,  Ferenc L. Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John L. Herrmann ,  William J. LaRochelle ,  Henri Lichenstein ,  Linda Gorman ,  Mei Zhong ,  Muralidhara Padigaru ,  Carol E. A. Pena ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Daniel K. Rieger ,  William Grosse

发明人： Richard A. Shimkets ,  Michael Jeffers ,  Sudhirdas K. Prayaga ,  Ferenc L. Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John L. Herrmann ,  William J. LaRochelle ,  Henri Lichenstein ,  Linda Gorman ,  Mei Zhong ,  Muralidhara Padigaru ,  Carol E. A. Pena ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Daniel K. Rieger ,  William Grosse

IPC分类号： C07K14/50 ,  A61K38/18 ,  A61K38/00 ,  G01N33/53

CPC分类号： C07K14/50 ,  A61K38/1825 ,  A61K48/00 ,  A61K2039/505 ,  Y10S435/975

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20110257035A1

公开(公告)日：2011-10-20

申请号：US13125212

申请日：2009-10-21

申请人： Carol E. A. Pena

发明人： Carol E. A. Pena

IPC分类号： C40B30/04 ,  C40B40/06 ,  C12Q1/02 ,  C40B40/10 ,  C12Q1/48 ,  C12Q1/34

CPC分类号： G01N33/57438 ,  G01N33/74 ,  G01N2333/71 ,  G01N2333/82 ,  G01N2800/52 ,  G01N2800/60

摘要： The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection, prognostication and guidance for the treatment of patients with hepatocellular carcinoma (HCC); and (2) discovery of an expression signature that can be used to monitor and/or study the efficacy of a chemotherapeutic regimen, such as, for example, sorafenib (solely or in combination with other agents). The present invention also provides a method for predicting clinical outcomes, such as, for example, overall survival (OS), time to progression (TTP) and/or likelihood of benefitting from a chemotherapeutic treatment (i.e., sorafenib) in HCC patients based on the analysis of such biomarkers.

摘要翻译： 本发明涉及例如（1）用于鉴定临床有用的血清和/或肿瘤生物标志物和表达特征的新方法，其可用于治疗肝细胞癌（HCC）患者的检测，预后和指导， ; 和（2）可以用于监测和/或研究化疗方案的功效的表达特征的发现，例如索拉非尼（单独地或与其它药剂组合）。 本发明还提供了一种用于预测临床结果的方法，例如，基于总体存活（OS），进展时间（TTP）和/或从HCC患者的化疗治疗（即索拉菲尼）受益的可能性 对这些生物标志物的分析。