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公开(公告)号：US07034132B2
公开(公告)日：2006-04-25
申请号：US10162335
申请日：2002-06-03
申请人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
发明人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07109000B2
公开(公告)日：2006-09-19
申请号：US10087684
申请日：2002-03-01
申请人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
发明人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US06974684B2
公开(公告)日：2005-12-13
申请号：US10211689
申请日：2002-08-01
申请人： David W. Anderson , John P. Alsobrook II , Ferenc L. Boldog , Catherine E. Burgess , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Linda Gorman , Xiaojia Sasha Guo , Nikolai Khramtsov , Denise M. Lepley , John R. MacDougall , Carol E. A. Pena , John A. Peyman , Meera Patturajan , Daniel K. Rieger , Richard A. Shimkets , Glennda Smithson , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Mei Zhong
发明人： David W. Anderson , John P. Alsobrook II , Ferenc L. Boldog , Catherine E. Burgess , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Linda Gorman , Xiaojia Sasha Guo , Nikolai Khramtsov , Denise M. Lepley , John R. MacDougall , Carol E. A. Pena , John A. Peyman , Meera Patturajan , Daniel K. Rieger , Richard A. Shimkets , Glennda Smithson , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Mei Zhong
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US06964849B2
公开(公告)日：2005-11-15
申请号：US10099322
申请日：2002-03-15
IPC分类号： A61K38/00 , A61K47/48 , C07K14/47 , C07K14/705 , C07K16/18 , C12N9/36 , C12Q1/68 , A61K31/711 , C07H21/04 , C12N15/63
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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5.发明申请METHODS AND COMPOSITIONS FOR IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCERS ASSOCIATED WITH HEDGEHOG SIGNALING 审中-公开用HEDGEHOG信号相关的癌症鉴定，评估和治疗方法和组合公开(公告)号：US20120010230A1
公开(公告)日：2012-01-12
申请号：US13179438
申请日：2011-07-08
申请人： John R. MacDougall , Juan Guillermo Paez , Karen J. McGovern , Jeffery L. Kutok , Georgios Skliris , Kerry White , Kerrie L. Faia , Marisa Osswalt Peluso , Veronica Travaglione Campbell
发明人： John R. MacDougall , Juan Guillermo Paez , Karen J. McGovern , Jeffery L. Kutok , Georgios Skliris , Kerry White , Kerrie L. Faia , Marisa Osswalt Peluso , Veronica Travaglione Campbell
IPC分类号： A61K31/4355 , A61P35/02 , G01N33/53 , C12Q1/02 , C12Q1/68 , C12Q1/37 , C12Q1/48 , A61P35/00 , C40B30/04
CPC分类号： G01N33/57484 , A61K31/4355 , A61K31/7068 , A61K38/38 , A61K39/39558 , A61K45/06 , A61N5/1001 , C07K16/22 , C12Q1/37 , C12Q1/48 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/5041 , G01N33/574 , G01N2500/04 , G01N2800/50 , G01N2800/52 , G01N2800/56 , A61K2300/00
摘要： Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.
摘要翻译： 本文提供了用于评估样品（例如从癌症患者获得的样品）检测一种或多种刺猬生物标志物和/或一种或多种纤毛标记物的方法，测定和试剂盒。 因此，本发明尤其可以用于鉴定单独或与治疗剂组合可能受益于一种或多种刺猬蛋白抑制剂的受益的患者的手段; 预测疾病的时间过程或癌症患者疾病中重大事件的概率; 分层患者人群; 和/或更有效地治疗或预防与刺猬蛋白信号传导相关的癌症或肿瘤。
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公开(公告)号：US20120010229A1
公开(公告)日：2012-01-12
申请号：US13179404
申请日：2011-07-08
IPC分类号： A61K31/4355 , A61P35/00 , C07D491/04
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/337 , A61K31/4402 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Provided herein are methods, therapeutic regimens, and kits that optimize the benefits of hedgehog inhibition for cancer therapy.
摘要翻译： 本文提供的方法，治疗方案和试剂盒优化刺猬抑制癌症治疗的益处。
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公开(公告)号：US06875570B2
公开(公告)日：2005-04-05
申请号：US09964956
申请日：2001-09-26
申请人： Valerie L. Gerlach , John R. MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Catherine E. Burgess , Muralidhara Padigaru , Ramesh Kekuda , Kimberly A. Spytek , Martin D. Leach , Richard A. Shimkets
发明人： Valerie L. Gerlach , John R. MacDougall , Glennda Smithson , Isabelle Millet , David Stone , Erik Gunther , Karen Ellerman , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Catherine E. Burgess , Muralidhara Padigaru , Ramesh Kekuda , Kimberly A. Spytek , Martin D. Leach , Richard A. Shimkets
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/14 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P27/02 , A61P35/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12Q1/68 , G01N33/566 , G01N33/574
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US06991901B2
公开(公告)日：2006-01-31
申请号：US10044564
申请日：2002-01-11
IPC分类号： C12Q1/68 , C12N15/63 , A61K31/711 , C07H21/04
CPC分类号： C07K16/18 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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