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公开(公告)号：US20140065210A1
公开(公告)日：2014-03-06
申请号：US13598383
申请日：2012-08-29
CPC分类号： A61K35/744 , A61K9/0034 , A61K35/742 , A61K35/745 , A61K35/747 , A61K36/064 , A61K36/48 , A61K36/899 , A61K38/48 , A61K2300/00
摘要： The present invention relates to a personal care product comprising a protein matrix wherein said protein matrix comprises at least one protein, at least one probiotic and a carrier fluid.The present invention also relates to the personal care product being a feminine care product particularly aimed at female urogenital health to treat or prevent vaginal infections. Oral and sinus infections, however, may also be benefited by the composition.
摘要翻译： 本发明涉及包含蛋白质基质的个人护理产品，其中所述蛋白质基质包含至少一种蛋白质，至少一种益生菌和载体流体。 本发明还涉及作为女性护理产品的个人护理产品，特别是针对女性泌尿生殖健康来治疗或预防阴道感染。 然而，口服和鼻窦感染也可能受益于组合物。
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公开(公告)号：US09648874B2
公开(公告)日：2017-05-16
申请号：US13330375
申请日：2011-12-19
CPC分类号： A01N31/08 , A01N25/10 , A01N65/00 , A01N65/22 , A61K8/0208 , A61K8/345 , A61K8/347 , A61K8/645 , A61K47/44 , A61Q19/00 , A61Q19/10 , A01N25/34 , A01N25/14
摘要： The present invention relates to a wipe suitable for multiple re-use comprising a biopolymer matrix composition, said biopolymer matrix comprising from about 0.1% to about 40% of an essential oil, about 30% to about 95% of a biopolymer, and about 1% to about 50% of a carrier fluid wherein a limited amount of said essential oil can be released from said matrix composition when exposed to a liquid solution; and wherein an additional limited amount of said essential oil can be re-released repetitiously thereafter upon re-use with an additional exposure of a liquid solution to said wipe.
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公开(公告)号：US09149045B2
公开(公告)日：2015-10-06
申请号：US12961619
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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4.发明申请公开(公告)号：US20120141569A1
公开(公告)日：2012-06-07
申请号：US12961611
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
CPC分类号： A61K31/05 , A01N31/08 , A01N65/00 , A61F13/36 , D06N3/0059 , D06N3/126 , D06N3/128 , D06N2209/1671 , D06N2211/08 , Y02A50/473 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： A wipe that contains a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil is volatile and tends to evaporate and lose efficacy during storage and prior to use, a protein is also employed in the composition to enhance long term stability of the oil and, in turn, its antimicrobial efficacy. The protein is “film-forming” in the sense that it tends to form a substantially continuous film when coated onto a surface of the fibrous web. Because such proteins are typically stiff and brittle in nature, a continuous film would restrict the ability of the fibers to move and bend, thereby reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the fibrous web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve such a discontinuous coating without adversely impacting the ability of the protein to stabilize the botanical oil. The organopolysiloxane may also enhance the softness and overall handfeel of the wipe.
摘要翻译： 提供了一种包含其上涂有抗微生物组合物的纤维网的擦拭物。 组合物包括衍生自植物（例如百里酚，香芹酚等）的植物油。 由于植物油是挥发性的，并且在储存期间和使用前易于蒸发并失去功效，所以组合物中还使用蛋白质以增强油的长期稳定性，进而提高其抗菌功效。 该蛋白质是“成膜”的意思，即当涂布在纤维网的表面上时，其趋向于形成基本连续的膜。 因为这种蛋白质本质上通常是硬而脆的，所以连续的膜会限制纤维移动和弯曲的能力，从而降低纤维网的柔韧性和悬垂性。 因此，通常希望抗微生物组合物在纤维网上形成不连续的涂层。 在这方面，本发明人惊奇地发现，加入有机聚硅氧烷可有助于实现这种不连续涂层，而不会不利地影响蛋白质稳定植物油的能力。 有机聚硅氧烷还可以增强擦拭物的柔软度和整体手感。
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公开(公告)号：US10821085B2
公开(公告)日：2020-11-03
申请号：US12961611
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
IPC分类号： A01N25/34 , A01P1/00 , B05D3/02 , A61K31/05 , A01N65/00 , A01N31/08 , D06N3/12 , D06N3/00 , A61F13/36
摘要： A wipe containing a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the oil is volatile and tends to evaporate and lose efficacy prior to use, a protein is also employed to enhance the composition's long term stability and antimicrobial efficacy. The protein tends to form a substantially continuous film when coated onto the fibrous web. Because such proteins are typically stiff and brittle, a continuous film would restrict the ability of the fibers to move and bend, reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve a discontinuous coating without adversely impacting the ability of the protein to stabilize the oil.
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公开(公告)号：US20120141571A1
公开(公告)日：2012-06-07
申请号：US12961619
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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公开(公告)号：US09040598B2
公开(公告)日：2015-05-26
申请号：US13370883
申请日：2012-02-10
IPC分类号： C08J9/00 , C08G59/42 , C08L23/02 , C08L33/02 , C08L67/04 , C08L33/00 , C08L67/00 , C08L71/00 , C08L23/08 , C08L23/10
CPC分类号： C08L67/04 , C08L23/02 , C08L23/0815 , C08L23/10 , C08L33/00 , C08L63/00 , C08L67/00 , C08L71/00 , C08L2205/02 , C08L2205/03 , C08L2207/04 , C08L23/08 , C08L23/16
摘要： A thermoplastic composition that contains a rigid renewable polyester and has a voided structure and low density is provided. To achieve such a structure, the renewable polyester is blended with a polymeric toughening additive to form a precursor material in which the toughening additive can be dispersed as discrete physical domains within a continuous matrix of the renewable polyester. The precursor material is thereafter stretched or drawn at a temperature below the glass transition temperature of the polyester (i.e., “cold drawn”). This creates a network of voids located adjacent to the discrete domains, which as a result of their proximal location, can form a bridge between the boundaries of the voids and act as internal structural “hinges” that help stabilize the network and increase its ability to dissipate energy. The present inventors have also discovered that the voids can be distributed in a substantially homogeneous fashion throughout the composition.
摘要翻译： 提供含有刚性可再生聚酯并且具有空隙结构和低密度的热塑性组合物。 为了实现这种结构，可再生聚酯与聚合物增韧添加剂共混以形成前体材料，其中增韧添加剂可以作为离散物理区域分散在可再生聚酯的连续基质内。 然后将该前体材料在低于聚酯的玻璃化转变温度的温度（即“冷拉伸”）下拉伸或拉伸。 这创造了一个位于邻近离散区域的空隙网络，由于它们的近端位置，它们可以在空隙的边界之间形成桥梁，并且作为有助于稳定网络并增加其网络的能力的内部结构“铰链” 消耗能量。 本发明人还发现，空隙可以在整个组合物中以基本均匀的方式分布。
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8.发明授权公开(公告)号：US08524264B2
公开(公告)日：2013-09-03
申请号：US12961634
申请日：2010-12-07
CPC分类号： A01N25/02 , A01N31/08 , A01N43/90 , A01N65/00 , B29B7/42 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0026 , B29C47/025 , B29C47/6056 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92828 , B29C2947/92876 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/20 , A01N65/22 , A01N65/44
摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
摘要翻译： 提供了一种形成抗微生物组合物的方法，其包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白质相关的问题，本发明人已经发现可以选择性地控制加工条件和组分以允许形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混期间使用的挤出温度和剪切速率相对较低，以帮助限制多肽解离，从而最小化聚集和脆化的影响。 虽然使用这种低温/剪切条件往往会降低混合效率，但是本发明人已经发现，可以使用载体流体来提高植物油流入蛋白质的内部结构的能力，其中可以是 保持稳定。 组合物通常也是无水的，通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并过早释放植物油。
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公开(公告)号：US20130210308A1
公开(公告)日：2013-08-15
申请号：US13370952
申请日：2012-02-10
CPC分类号： D01F6/92 , B29C48/0018 , B29C48/022 , B29C48/04 , B29C48/05 , B29C48/30 , B29C48/345 , B29C48/802 , B29C48/911 , B29C2948/92704 , D01D5/12 , D01D5/247 , D01F1/10 , D04H3/16 , Y10T428/2913 , Y10T442/608
摘要： Fibers that are formed from a thermoplastic composition that contains a rigid renewable polyester and has a voided structure and low density are provided. To achieve such a structure, the renewable polyester is blended with a polymeric toughening additive in which the toughening additive can be dispersed as discrete physical domains within a continuous matrix of the renewable polyester. Fibers are thereafter formed and then stretched or drawn at a temperature below the glass transition temperature of the polyester (i.e., “cold drawn”).
摘要翻译： 提供由含有刚性可再生聚酯并且具有空隙结构和低密度的热塑性组合物形成的纤维。 为了实现这种结构，可再生聚酯与聚合增韧添加剂共混，其中增韧添加剂可以作为可再生聚酯的连续基质中的离散物理区域分散。 之后形成纤维，然后在低于聚酯的玻璃化转变温度的温度（即“冷拉伸”）下拉伸或拉伸。
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公开(公告)号：US08445032B2
公开(公告)日：2013-05-21
申请号：US12961625
申请日：2010-12-07
CPC分类号： A61K47/42 , A01N25/28 , A61K8/0208 , A61K8/645 , A61Q17/005 , A61Q19/10 , C08K5/0016 , C08K5/0025 , C08K5/053 , C08K5/09 , C08K5/1515 , C08L89/00 , A01N25/10 , A01N65/00
摘要： A melt-processed protein composition formed from a protein, plasticizer, and an electrophilic reagent is provided. The electrophilic reagent, for instance, may be selected to undergo a nucleophilic addition reaction with free sulfhydryl and/or thiyl radicals to help minimize the formation of disulfide crosslinking bonds that could otherwise lead to protein aggregation during melt processing. To enhance the degree to which the electrophilic reagent can limit crosslinking, a plasticizer is also employed that helps to mediate the adsorption of the electrophilic reagent into the internal structure of the protein, where it can be more stably retained. Furthermore, the temperature and shear rate employed during melt blending may also be selected to be relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement.
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