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公开(公告)号：US09149045B2
公开(公告)日：2015-10-06
申请号：US12961619
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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2.发明申请公开(公告)号：US20120141569A1
公开(公告)日：2012-06-07
申请号：US12961611
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
CPC分类号： A61K31/05 , A01N31/08 , A01N65/00 , A61F13/36 , D06N3/0059 , D06N3/126 , D06N3/128 , D06N2209/1671 , D06N2211/08 , Y02A50/473 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： A wipe that contains a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil is volatile and tends to evaporate and lose efficacy during storage and prior to use, a protein is also employed in the composition to enhance long term stability of the oil and, in turn, its antimicrobial efficacy. The protein is “film-forming” in the sense that it tends to form a substantially continuous film when coated onto a surface of the fibrous web. Because such proteins are typically stiff and brittle in nature, a continuous film would restrict the ability of the fibers to move and bend, thereby reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the fibrous web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve such a discontinuous coating without adversely impacting the ability of the protein to stabilize the botanical oil. The organopolysiloxane may also enhance the softness and overall handfeel of the wipe.
摘要翻译： 提供了一种包含其上涂有抗微生物组合物的纤维网的擦拭物。 组合物包括衍生自植物（例如百里酚，香芹酚等）的植物油。 由于植物油是挥发性的，并且在储存期间和使用前易于蒸发并失去功效，所以组合物中还使用蛋白质以增强油的长期稳定性，进而提高其抗菌功效。 该蛋白质是“成膜”的意思，即当涂布在纤维网的表面上时，其趋向于形成基本连续的膜。 因为这种蛋白质本质上通常是硬而脆的，所以连续的膜会限制纤维移动和弯曲的能力，从而降低纤维网的柔韧性和悬垂性。 因此，通常希望抗微生物组合物在纤维网上形成不连续的涂层。 在这方面，本发明人惊奇地发现，加入有机聚硅氧烷可有助于实现这种不连续涂层，而不会不利地影响蛋白质稳定植物油的能力。 有机聚硅氧烷还可以增强擦拭物的柔软度和整体手感。
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公开(公告)号：US10821085B2
公开(公告)日：2020-11-03
申请号：US12961611
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
IPC分类号： A01N25/34 , A01P1/00 , B05D3/02 , A61K31/05 , A01N65/00 , A01N31/08 , D06N3/12 , D06N3/00 , A61F13/36
摘要： A wipe containing a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the oil is volatile and tends to evaporate and lose efficacy prior to use, a protein is also employed to enhance the composition's long term stability and antimicrobial efficacy. The protein tends to form a substantially continuous film when coated onto the fibrous web. Because such proteins are typically stiff and brittle, a continuous film would restrict the ability of the fibers to move and bend, reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve a discontinuous coating without adversely impacting the ability of the protein to stabilize the oil.
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公开(公告)号：US20120141571A1
公开(公告)日：2012-06-07
申请号：US12961619
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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公开(公告)号：US09648874B2
公开(公告)日：2017-05-16
申请号：US13330375
申请日：2011-12-19
CPC分类号： A01N31/08 , A01N25/10 , A01N65/00 , A01N65/22 , A61K8/0208 , A61K8/345 , A61K8/347 , A61K8/645 , A61K47/44 , A61Q19/00 , A61Q19/10 , A01N25/34 , A01N25/14
摘要： The present invention relates to a wipe suitable for multiple re-use comprising a biopolymer matrix composition, said biopolymer matrix comprising from about 0.1% to about 40% of an essential oil, about 30% to about 95% of a biopolymer, and about 1% to about 50% of a carrier fluid wherein a limited amount of said essential oil can be released from said matrix composition when exposed to a liquid solution; and wherein an additional limited amount of said essential oil can be re-released repetitiously thereafter upon re-use with an additional exposure of a liquid solution to said wipe.
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公开(公告)号：US20140065210A1
公开(公告)日：2014-03-06
申请号：US13598383
申请日：2012-08-29
CPC分类号： A61K35/744 , A61K9/0034 , A61K35/742 , A61K35/745 , A61K35/747 , A61K36/064 , A61K36/48 , A61K36/899 , A61K38/48 , A61K2300/00
摘要： The present invention relates to a personal care product comprising a protein matrix wherein said protein matrix comprises at least one protein, at least one probiotic and a carrier fluid.The present invention also relates to the personal care product being a feminine care product particularly aimed at female urogenital health to treat or prevent vaginal infections. Oral and sinus infections, however, may also be benefited by the composition.
摘要翻译： 本发明涉及包含蛋白质基质的个人护理产品，其中所述蛋白质基质包含至少一种蛋白质，至少一种益生菌和载体流体。 本发明还涉及作为女性护理产品的个人护理产品，特别是针对女性泌尿生殖健康来治疗或预防阴道感染。 然而，口服和鼻窦感染也可能受益于组合物。
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公开(公告)号：US20110135702A1
公开(公告)日：2011-06-09
申请号：US12633883
申请日：2009-12-09
申请人： Douglas R. Hoffman , Aimin He , David W. Koenig , Andrea J. Smiltneek , DaeGun Kim , YoungSook Kim
发明人： Douglas R. Hoffman , Aimin He , David W. Koenig , Andrea J. Smiltneek , DaeGun Kim , YoungSook Kim
IPC分类号： A01N25/08 , A01N59/16 , A01N59/20 , A01N59/08 , A01N37/52 , A01N33/12 , A01N31/14 , A01N31/00 , A01P1/00
CPC分类号： A01N45/00 , A01N37/44 , A01N2300/00 , A01N25/00 , A01N31/02 , A01N31/16 , A01N33/24 , A01N47/44 , A01N59/02
摘要： A cleaning medium or formulation that contains a sporicidal composition is described. The composition includes about 0.1-20% weight/weight of a germinant agent, about 0.01-75% w/w of an antimicrobial agent, in terms of dry or wet total weight, and which is admixed with water to generate a solution with a pH of 3.5-9.5. The composition can help trigger the germination of spores, in particular C. difficile, and subsequently deactivate or kill the spores. A means of applying the cleaning formulation in a medium and process for cleaning are also described.
摘要翻译： 描述了含有杀芽孢组合物的清洁介质或制剂。 组合物包含约0.1-20％重量/重量的发芽剂，约0.01-75％w / w的抗微生物剂，以干或湿总重量计，并且与水混合以产生具有 pH值3.5-9.5。 组合物可以帮助触发孢子的发芽，特别是艰难梭菌，然后使孢子失活或杀死。 还描述了将清洁制剂应用于介质和清洁方法的手段。
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公开(公告)号：US08353888B2
公开(公告)日：2013-01-15
申请号：US12900020
申请日：2010-10-07
申请人： David W. Koenig , Wael R. Joseph
发明人： David W. Koenig , Wael R. Joseph
IPC分类号： A61F13/15
CPC分类号： A61F13/0203 , A61F13/82
摘要： An article has a body facing engagement surface for contacting a wearer's tissue layer. The body facing engagement surface has a first state adapted to inhibit movement of the article with respect to the wearer's tissue layer, and a second state adapted to enhance movement of the article with respect to the tissue layer. The body facing engagement surface is adapted to transform from the first state to the second state upon application of a force greater than a threshold force. The body facing engagement surface has a gripping component that overlies a sliding component in the first state. The gripping component is disposed for engaging and gripping the tissue layer in the first state until a force greater than the threshold force is encountered which transforms the engagement surface to promote relative sliding motion between the engagement surface and the tissue layer.
摘要翻译： 制品具有接触穿用者组织层的面向身体的接合表面。 身体接合表面具有适于阻止制品相对于穿着者组织层移动的第一状态，以及适于增强制品相对于组织层的移动的第二状态。 面向身体的接合表面适于在施加大于阈值力的力时从第一状态转换到第二状态。 面向身体的接合表面具有在第一状态下覆盖滑动部件的抓握部件。 夹持部件被布置成用于在第一状态下接合和夹持组织层，直到遇到大于阈值力的力，其转换接合表面以促进接合表面和组织层之间的相对滑动运动。
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公开(公告)号：US20110022016A1
公开(公告)日：2011-01-27
申请号：US12900028
申请日：2010-10-07
申请人： David W. Koenig , Wael R. Joseph
发明人： David W. Koenig , Wael R. Joseph
IPC分类号： A61F13/511
CPC分类号： A61F13/0203 , A61F13/82
摘要： A contact layer has an engagement surface adapted to contact a user's tissue layer. The contact layer is constructed so that the engagement surface has a first state adapted to inhibit movement of the contact layer with respect to the tissue layer of the user, and a second state adapted to enhance movement of the contact layer with respect to the tissue layer of the user. The engagement surface is adapted to transform from the first state to the second state upon application of a force greater than a threshold force.
摘要翻译： 接触层具有适于接触使用者的组织层的接合表面。 接触层被构造成使得接合表面具有适于阻止接触层相对于使用者的组织层移动的第一状态，以及适于增强接触层相对于组织层的移动的第二状态 的用户。 接合表面适于在施加大于阈值力的力时从第一状态转换到第二状态。
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10.发明申请PERSONAL CARE ARTICLE WITH SUBSTRATE SURFACE TOPOGRAPHY FOR EVOKING A NEUROSENSORY SKIN RESPONSE 有权个人护理文章与基底表面地形学用于激发神经病学皮肤反应公开(公告)号：US20090118690A1
公开(公告)日：2009-05-07
申请号：US11931419
申请日：2007-10-31
申请人： Jason C. Cohen , David W. Koenig
发明人： Jason C. Cohen , David W. Koenig
IPC分类号： A61F13/512
CPC分类号： A61F13/51104
摘要： In a personal care article for contact with human skin, a non-woven substrate of the article has a longitudinal direction, a transverse direction and at least one skin-contact surface. A plurality of surface features is disposed on the at least one skin-contact surface in a sinusoidal wave-form along at least one of the longitudinal direction and the transverse direction of the substrate. The surface features have a height that generally defines an amplitude of the sinusoidal wave-form, and are spaced from each other a spatial distance. This spatial distance is at least in part a function of a movement speed at which the article is to be moved relative to the skin while in contact therewith. In one method of making such a substrate, the movement speed and a temporal frequency are selected and used to determine the spacing between surface features on the skin-contact surface of the substrate.
摘要翻译： 在与人体皮肤接触的个人护理制品中，制品的无纺基材具有纵向，横向和至少一个皮肤接触表面。 多个表面特征沿着基板的纵向方向和横向方向中的至少一个以正弦波形布置在至少一个皮肤接触表面上。 表面特征具有通常限定正弦波形的幅度并且彼此间隔距离的高度。 该空间距离至少部分地是在与之接触的同时相对于皮肤移动物品的移动速度的函数。 在制造这种基板的一种方法中，选择移动速度和时间频率并用于确定基板的皮肤接触表面上的表面特征之间的间隔。
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