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公开(公告)号：US09648874B2
公开(公告)日：2017-05-16
申请号：US13330375
申请日：2011-12-19
CPC分类号： A01N31/08 , A01N25/10 , A01N65/00 , A01N65/22 , A61K8/0208 , A61K8/345 , A61K8/347 , A61K8/645 , A61K47/44 , A61Q19/00 , A61Q19/10 , A01N25/34 , A01N25/14
摘要： The present invention relates to a wipe suitable for multiple re-use comprising a biopolymer matrix composition, said biopolymer matrix comprising from about 0.1% to about 40% of an essential oil, about 30% to about 95% of a biopolymer, and about 1% to about 50% of a carrier fluid wherein a limited amount of said essential oil can be released from said matrix composition when exposed to a liquid solution; and wherein an additional limited amount of said essential oil can be re-released repetitiously thereafter upon re-use with an additional exposure of a liquid solution to said wipe.
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公开(公告)号：US09149045B2
公开(公告)日：2015-10-06
申请号：US12961619
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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3.发明申请公开(公告)号：US20120141569A1
公开(公告)日：2012-06-07
申请号：US12961611
申请日：2010-12-07
申请人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
CPC分类号： A61K31/05 , A01N31/08 , A01N65/00 , A61F13/36 , D06N3/0059 , D06N3/126 , D06N3/128 , D06N2209/1671 , D06N2211/08 , Y02A50/473 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： A wipe that contains a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil is volatile and tends to evaporate and lose efficacy during storage and prior to use, a protein is also employed in the composition to enhance long term stability of the oil and, in turn, its antimicrobial efficacy. The protein is “film-forming” in the sense that it tends to form a substantially continuous film when coated onto a surface of the fibrous web. Because such proteins are typically stiff and brittle in nature, a continuous film would restrict the ability of the fibers to move and bend, thereby reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the fibrous web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve such a discontinuous coating without adversely impacting the ability of the protein to stabilize the botanical oil. The organopolysiloxane may also enhance the softness and overall handfeel of the wipe.
摘要翻译： 提供了一种包含其上涂有抗微生物组合物的纤维网的擦拭物。 组合物包括衍生自植物（例如百里酚，香芹酚等）的植物油。 由于植物油是挥发性的，并且在储存期间和使用前易于蒸发并失去功效，所以组合物中还使用蛋白质以增强油的长期稳定性，进而提高其抗菌功效。 该蛋白质是“成膜”的意思，即当涂布在纤维网的表面上时，其趋向于形成基本连续的膜。 因为这种蛋白质本质上通常是硬而脆的，所以连续的膜会限制纤维移动和弯曲的能力，从而降低纤维网的柔韧性和悬垂性。 因此，通常希望抗微生物组合物在纤维网上形成不连续的涂层。 在这方面，本发明人惊奇地发现，加入有机聚硅氧烷可有助于实现这种不连续涂层，而不会不利地影响蛋白质稳定植物油的能力。 有机聚硅氧烷还可以增强擦拭物的柔软度和整体手感。
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公开(公告)号：US10821085B2
公开(公告)日：2020-11-03
申请号：US12961611
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim , David W. Koenig , James H. Wang
IPC分类号： A01N25/34 , A01P1/00 , B05D3/02 , A61K31/05 , A01N65/00 , A01N31/08 , D06N3/12 , D06N3/00 , A61F13/36
摘要： A wipe containing a fibrous web on which is coated an antimicrobial composition is provided. The composition includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the oil is volatile and tends to evaporate and lose efficacy prior to use, a protein is also employed to enhance the composition's long term stability and antimicrobial efficacy. The protein tends to form a substantially continuous film when coated onto the fibrous web. Because such proteins are typically stiff and brittle, a continuous film would restrict the ability of the fibers to move and bend, reducing web flexibility and drape. Thus, it is typically desired that the antimicrobial composition form a discontinuous coating on the web. In this regard, the present inventors have surprisingly discovered that the addition of an organopolysiloxane can help achieve a discontinuous coating without adversely impacting the ability of the protein to stabilize the oil.
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公开(公告)号：US20120141571A1
公开(公告)日：2012-06-07
申请号：US12961619
申请日：2010-12-07
申请人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
发明人： Jaehong Lee , Vasily A. Topolkaraev , David W. Koenig , Neil T. Scholl , YoungSook Kim , James H. Wang
CPC分类号： A01N65/00 , A01N31/08 , A01N2300/00 , A01N25/04 , A01N25/10 , A01N25/22 , A01N25/34 , A01N65/22
摘要： An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
摘要翻译： 提供了一种环保且具有抗菌活性的水包油乳液。 更具体地，乳液的油相包括衍生自植物（例如百里酚，香芹酚等）的植物油。 因为植物油在储存期间倾向于从乳液中浸出，并且在用于所需应用之前，在乳液的水相中也使用水分散性聚合物，以提高油的长期稳定性，反过来 ，抗菌功效。 不期望受理论的限制，认为水分散性聚合物可以有效地将植物油包封在乳液内并抑制其过早释放。 一旦形成乳液，然后可以除去水，使其成为基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳程度的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。
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6.发明授权公开(公告)号：US08524264B2
公开(公告)日：2013-09-03
申请号：US12961634
申请日：2010-12-07
CPC分类号： A01N25/02 , A01N31/08 , A01N43/90 , A01N65/00 , B29B7/42 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0026 , B29C47/025 , B29C47/6056 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92828 , B29C2947/92876 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/20 , A01N65/22 , A01N65/44
摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
摘要翻译： 提供了一种形成抗微生物组合物的方法，其包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白质相关的问题，本发明人已经发现可以选择性地控制加工条件和组分以允许形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混期间使用的挤出温度和剪切速率相对较低，以帮助限制多肽解离，从而最小化聚集和脆化的影响。 虽然使用这种低温/剪切条件往往会降低混合效率，但是本发明人已经发现，可以使用载体流体来提高植物油流入蛋白质的内部结构的能力，其中可以是 保持稳定。 组合物通常也是无水的，通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并过早释放植物油。
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公开(公告)号：US09832993B2
公开(公告)日：2017-12-05
申请号：US12961638
申请日：2010-12-07
申请人： James H. Wang , Bo Shi , JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim
发明人： James H. Wang , Bo Shi , JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim
IPC分类号： A01N31/08 , A01N65/00 , B29C47/00 , B29C47/60 , B29B7/10 , B29B7/38 , B29B9/06 , B29B9/12 , B29B9/16
CPC分类号： A01N31/08 , A01N65/00 , B29B7/10 , B29B7/38 , B29B9/06 , B29B9/12 , B29B9/16 , B29C47/00 , B29C47/6087 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/08 , A01N65/20 , A01N65/24 , A01N65/28 , A01N65/38
摘要： A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.
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公开(公告)号：US20120141567A1
公开(公告)日：2012-06-07
申请号：US12961638
申请日：2010-12-07
申请人： James H. Wang , Bo Shi , JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim
发明人： James H. Wang , Bo Shi , JaeHong Lee , Vasily A. Topolkaraev , Neil T. Scholl , YoungSook Kim
CPC分类号： A01N31/08 , A01N65/00 , B29B7/10 , B29B7/38 , B29B9/06 , B29B9/12 , B29B9/16 , B29C47/00 , B29C47/6087 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/08 , A01N65/20 , A01N65/24 , A01N65/28 , A01N65/38
摘要： A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.
摘要翻译： 提供了一种形成组合物的方法，其包括在熔融共混装置（例如挤出机）中混合抗微生物活性植物油（例如百里酚，香芹酚等）和改性淀粉聚合物。 与蛋白质相关的问题不同，淀粉聚合物的使用允许在加工条件下具有更大程度的柔韧性，并且仍然能够在所得组合物中获得良好的性能。 本发明人还发现，可以使用增塑剂来促进淀粉的熔融加工，以及提高植物油流入淀粉内部结构的能力，其中它可以以稳定的方式保持。 组合物通常通常也不含溶剂。 以这种方式，淀粉在使用前通常不会分散，并且过早地释放植物油。 然而，由于改性淀粉的水敏感性，当需要释放植物油时，随后可以通过水分分散。
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9.发明申请公开(公告)号：US20120141566A1
公开(公告)日：2012-06-07
申请号：US12961634
申请日：2010-12-07
CPC分类号： A01N25/02 , A01N31/08 , A01N43/90 , A01N65/00 , B29B7/42 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0026 , B29C47/025 , B29C47/6056 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92828 , B29C2947/92876 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/20 , A01N65/22 , A01N65/44
摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
摘要翻译： 提供了一种形成抗微生物组合物的方法，其包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白质相关的问题，本发明人已经发现可以选择性地控制加工条件和组分以允许形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混期间使用的挤出温度和剪切速率相对较低，以帮助限制多肽解离，从而最小化聚集和脆化的影响。 虽然使用这种低温/剪切条件往往会降低混合效率，但是本发明人已经发现，可以使用载体流体来提高植物油流入蛋白质的内部结构的能力，其中可以是 保持稳定。 组合物通常也是无水的，通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并过早释放植物油。
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公开(公告)号：US20140065210A1
公开(公告)日：2014-03-06
申请号：US13598383
申请日：2012-08-29
CPC分类号： A61K35/744 , A61K9/0034 , A61K35/742 , A61K35/745 , A61K35/747 , A61K36/064 , A61K36/48 , A61K36/899 , A61K38/48 , A61K2300/00
摘要： The present invention relates to a personal care product comprising a protein matrix wherein said protein matrix comprises at least one protein, at least one probiotic and a carrier fluid.The present invention also relates to the personal care product being a feminine care product particularly aimed at female urogenital health to treat or prevent vaginal infections. Oral and sinus infections, however, may also be benefited by the composition.
摘要翻译： 本发明涉及包含蛋白质基质的个人护理产品，其中所述蛋白质基质包含至少一种蛋白质，至少一种益生菌和载体流体。 本发明还涉及作为女性护理产品的个人护理产品，特别是针对女性泌尿生殖健康来治疗或预防阴道感染。 然而，口服和鼻窦感染也可能受益于组合物。
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