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    Methods of identifying and detecting pancreatic cancer
    1.
    发明授权
    Methods of identifying and detecting pancreatic cancer 失效
    识别和检测胰腺癌的方法

    公开(公告)号：US06187536B1

    公开(公告)日：2001-02-13

    申请号：US09025534

    申请日：1998-02-18

    申请人： David Weinberg ,  Scott A. Waldman ,  Michael T. Barber ,  Sanjoy Biswas

    发明人： David Weinberg ,  Scott A. Waldman ,  Michael T. Barber ,  Sanjoy Biswas

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6886 ,  A61K47/62 ,  C12Q2600/112 ,  C12Q2600/136

    摘要： Conjugated compounds which comprises an CCK A receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an CCK A receptor binding moiety and a radiostable active moiety or an CCK A receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from pancreatic cancer are disclosed. Methods of radioimaging pancreatic cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has pancreatic cancer cells, for determining whether tumor cells are pancreatic in origin and for analyzing tissue samples to evaluate the extent of metastasis of pancreatic tumor cells.

    摘要翻译： 公开了包含CCK A受体结合部分和无定型活性部分的共轭化合物。 公开了包含CCK A受体结合部分和无稳定活性部分或CCK A受体结合部分和放射性活性部分的共轭化合物的药物组合物。 公开了治疗怀疑患有胰腺癌的个体的方法。 公开了放射成像胰腺癌细胞的方法。 公开了用于确定个体是否具有胰腺癌细胞的体外方法，试剂盒和试剂，用于确定肿瘤细胞是否在胰腺中起源，并用于分析组织样品以评估胰腺肿瘤细胞的转移程度。

    Compositions that specifically bind to colorectal cancer cells and methods of using the same
    2.
    发明授权
    Compositions that specifically bind to colorectal cancer cells and methods of using the same 有权
    特异性结合结肠直肠癌细胞的组合物及其使用方法

    公开(公告)号：US07135333B1

    公开(公告)日：2006-11-14

    申请号：US09649697

    申请日：2000-08-28

    申请人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    发明人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    IPC分类号： C12N5/10

    CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  G01N33/57419

    摘要： A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.

    摘要翻译： 公开了一种独特的转录产物CRCA-1和由其产生的替代的翻译产物。 转录物及其翻译产物是结肠直肠细胞的标志物。 公开了用于转移性结直肠癌的筛选和诊断试剂，试剂盒和方法，作为用于鉴定起源于结肠直肠的腺癌的试剂，试剂盒和方法。 公开了治疗转移性结肠直肠癌患者和体内成像转移性结肠直肠肿瘤的化合物，组合物和方法。 公开了将结合活性化合物如基因治疗剂和反义化合物递送至结肠直肠细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌的疫苗组合物和方法。

    Compositions that specifically bind to colorectal cancer cells and methods of using the same
    4.
    发明授权
    Compositions that specifically bind to colorectal cancer cells and methods of using the same 失效
    特异性结合结肠直肠癌细胞的组合物及其使用方法

    公开(公告)号：US07316902B2

    公开(公告)日：2008-01-08

    申请号：US10656895

    申请日：2003-09-05

    申请人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    发明人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  G01N33/57419

    摘要： A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed ars are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.

    摘要翻译： 公开了一种独特的转录产物CRCA-1和由其产生的替代的翻译产物。 转录物及其翻译产物是结肠直肠细胞的标志物。 公开了用于转移性结肠直肠癌的筛选和诊断试剂，试剂盒和方法，ar是用于鉴定起源于结肠直肠的腺癌的试剂，试剂盒和方法。 公开了治疗转移性结肠直肠癌患者和体内成像转移性结肠直肠肿瘤的化合物，组合物和方法。 公开了将结合活性化合物如基因治疗剂和反义化合物递送至结肠直肠细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌的疫苗组合物和方法。

    COMPOSITIONS FOR AND METHODS OF ACTIVATING GUANYLYL CYCLASE C
    6.
    发明申请
    COMPOSITIONS FOR AND METHODS OF ACTIVATING GUANYLYL CYCLASE C 审中-公开
    组合物和活化方法C

    公开(公告)号：US20120225099A1

    公开(公告)日：2012-09-06

    申请号：US13378658

    申请日：2010-02-24

    申请人： Scott A. Waldman ,  Giovanni Pitari ,  Tong Li

    发明人： Scott A. Waldman ,  Giovanni Pitari ,  Tong Li

    IPC分类号： A61K38/02 ,  A61K9/00 ,  A61P1/00 ,  A61K38/16 ,  A61P35/00 ,  C12N1/21 ,  A61K38/10

    CPC分类号： A61K35/74 ,  A61K35/741 ,  Y02A50/471 ,  Y02A50/473

    摘要： Isolated non-pathogenic bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to regulatory sequences operable in bacterium and isolated bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to inducible regulatory sequences operable in bacterium are disclosed. Isolated culture of such bacteria and uses thereof in the prevention and treatment of colonic polyps and/or colorectal cancer as well as methods of activating guanylyl cyclase C in humans are disclosed.

    摘要翻译： 分离的非致病细菌，其包含编码可以在细菌和分离的细菌中可操作的调节序列可操作地连接的调控序列的鸟苷酸环化酶C激动剂的核酸分子，其包含编码与可在细菌中可操作的可诱导调节序列可操作地连接的鸟苷酸环化酶C激动剂的核酸分子 披露 公开了这种细菌的分离培养物及其在预防和治疗结肠息肉和/或结肠直肠癌中的用途以及在人中激活鸟苷酸环化酶C的方法。

    Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same
    7.
    发明申请
    Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same 审中-公开
    癌症疫苗对粘膜抗原的制备和使用方法

    公开(公告)号：US20110206736A1

    公开(公告)日：2011-08-25

    申请号：US13120144

    申请日：2009-09-22

    申请人： Scott A. Waldman ,  Adam E. Snook

    发明人： Scott A. Waldman ,  Adam E. Snook

    IPC分类号： A61K39/00 ,  C07H21/04 ,  C12N7/00 ,  C07K14/00 ,  C12N9/96 ,  A61P35/00

    CPC分类号： A61K39/0011 ,  A61K2039/57

    摘要： Nucleic acid molecules comprising a nucleotide sequence that encodes a chimeric protein are disclosed. The chimeric proteins comprise at least one epitope of a mucosally restricted antigen, at least one CD4+ helper epitope, and, optionally, a secretion sequence. Chimeric proteins that comprise at least one epitope of a mucosally restricted antigen, at least one CD4+helper epitope and, optionally a secretion sequence are also disclosed. Compositions including pharmaceutical compositions and injectables comprising nucleic acid molecule and proteins are disclosed. Methods of treating individuals diagnosed with cancer of a mucosal tissue and methods of preventing cancer of a mucosal tissue are disclosed.

    摘要翻译： 公开了包含编码嵌合蛋白质的核苷酸序列的核酸分子。 嵌合蛋白质包含粘膜受限抗原，至少一种CD4 +辅助表位和任选的分泌序列的至少一个表位。 还公开了包含粘膜受限抗原的至少一个表位，至少一种CD4 +辅助表位和任选的分泌序列的嵌合蛋白。 公开了包含药物组合物和包含核酸分子和蛋白质的注射剂的组合物。 公开了治疗患有粘膜组织癌症的个体的方法和预防粘膜组织癌症的方法。

    METASTATIC COLORECTAL CANCER VACCINE
    8.
    发明申请
    METASTATIC COLORECTAL CANCER VACCINE 有权
    分子性阴道癌疫苗

    公开(公告)号：US20100196408A1

    公开(公告)日：2010-08-05

    申请号：US12564887

    申请日：2009-09-22

    申请人： Scott A. Waldman

    发明人： Scott A. Waldman

    IPC分类号： A61K39/00 ,  A61K39/12 ,  C07K14/00 ,  A61K39/23

    CPC分类号： C07K14/705 ,  A61K39/00

    摘要： The invention relates to prophylactic and therapeutic vaccines for protecting individuals against metastatic colorectal cancer and for treating individuals who are suffering from metastatic colorectal cancer.

    摘要翻译： 本发明涉及用于保护个体免受转移性结肠直肠癌和用于治疗患有转移性结肠直肠癌的个体的预防和治疗性疫苗。

    ST receptor binding compounds and methods of using the same
    9.
    发明授权
    ST receptor binding compounds and methods of using the same 有权
    ST受体结合化合物及其使用方法

    公开(公告)号：US07744870B1

    公开(公告)日：2010-06-29

    申请号：US09724983

    申请日：2000-11-28

    申请人： Scott A. Waldman

    发明人： Scott A. Waldman

    IPC分类号： A61K39/395 ,  A61K35/12

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/6425 ,  A61K51/08 ,  A61K2121/00 ,  C07K14/24 ,  Y02A50/473

    摘要： Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent, and a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive, active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer comprising the steps of administering to said individual a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent, and a therapeutically effective amount of a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radiostable active moiety are disclosed. Methods of radioimaging metastasized colorectal cancer cells comprising the steps of first administering to an individual suspected of having metastasized colorectal cancer cells, a pharmaceutical composition that comprises a pharmaceutically acceptable carrier or diluent, and conjugated compound that comprises an ST receptor binding moiety and a radioactive active moiety wherein the conjugated compound is present in an amount effective for diagnostic use in humans suffering from colorectal cancer and then detecting the localization and accumulation of radioactivity in the individual's body are disclosed.

    摘要翻译： 公开了包含ST受体结合部分和无定型活性部分的共轭化合物。 公开了包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和不稳定活性部分或ST受体结合部分和放射性活性部分的共轭化合物。 治疗疑似患有转移性结肠直肠癌的个体的方法包括以下步骤：向所述个体施用包含药学上可接受的载体或稀释剂的药物组合物和治疗有效量的包含ST受体结合部分和不稳定的结合化合物 公开了活性部分或ST受体结合部分和无定型活性部分。 包括以下步骤的放射性成像转移性结肠直肠癌细胞的方法：首先给予疑似患有转移性结肠直肠癌细胞的个体，包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和放射性活性物质的缀合化合物 公开了其中偶联化合物以有效用于患有结肠直肠癌的人的诊断用量的量存在，然后检测个体身体中放射性的定位和积累的部分。