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23 条记录 (耗时 0.018 秒)

    Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
    8.
    发明授权
    Amides of hyaluronic acid and the derivatives thereof and a process for their preparation 有权
    透明质酸及其衍生物的酰胺及其制备方法

    公开(公告)号：US08575129B2

    公开(公告)日：2013-11-05

    申请号：US12623253

    申请日：2009-11-20

    申请人： Davide Bellini ,  Alessandra Topai

    发明人： Davide Bellini ,  Alessandra Topai

    IPC分类号： A61K31/728 ,  A61K31/715 ,  A61K31/738

    CPC分类号： C08B37/0072 ,  A61K31/4164 ,  A61K31/728 ,  A61K47/61 ,  A61K49/0002 ,  A61L24/043 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  C08L5/08

    摘要： An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O—, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4=H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, —CO—(CH2)2—COOY; Y=negative charge, or H; R5=—CO—CH3, H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.

    摘要翻译： 透明质酸或其衍生物的酰胺，其包含至少一个通式（I）的重复单元：其中R = NR 6 R 7，或脂族，芳族，芳基脂族，脂环族，杂环系列，OH，O-，醇的醇基 透明质酸组，脱酰透明质酸氨基; R 1，R 2，R 3，R 4 = H，SO 3 - ，衍生自脂族，芳族，芳基脂族，脂环族，杂环系列的羧酸的酰基-CO-（CH 2）2 -COOH; Y =负电荷，或H; R5 = -CO-CH3，H，SO3-，衍生自脂族，芳香族，芳基脂族，脂环族，杂环系列的羧酸的酰基，透明质酸的酰基; R6 =是H或脂族，芳族，芳基脂族，脂环族或杂环基团，取代或未取代的; R7 =是H或脂族，芳族，芳基脂族，脂环族或杂环基团，取代或未取代的; 其中R或R 5中的至少一个形成酰胺基。

    Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
    10.
    发明授权
    Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery 有权
    含有透明质酸酯，线和生物材料，以及它们在手术中的应用

    公开(公告)号：US06632802B2

    公开(公告)日：2003-10-14

    申请号：US09941055

    申请日：2001-08-28

    申请人： Davide Bellini ,  Lanfranco Callegaro

    发明人： Davide Bellini ,  Lanfranco Callegaro

    IPC分类号： A61K31715

    CPC分类号： A61L17/105 ,  C08B37/0072

    摘要： The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.

    摘要翻译： 本申请公开了透明质酸的酯，其中羧酸官能团的第一部分用芳脂族醇酯化，第二部分与至少一种具有10至22个碳原子的长链直链脂肪醇酯化。 剩余的未酯化的羧酸官能团（如果存在的话）是成盐的。 本申请进一步公开了具有复丝构象的生物相容性线，其包含由上述酯形成的长丝，以及它们在医学和外科领域中的用途。