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    Process for the biotransformation of colchicone compounds into the correspondence 3-glycosyl derivatives
    5.
    发明授权
    Process for the biotransformation of colchicone compounds into the correspondence 3-glycosyl derivatives 有权
    将秋水仙碱化合物生物转化成对应的3-糖基衍生物的方法

    公开(公告)号：US06372458B1

    公开(公告)日：2002-04-16

    申请号：US09539867

    申请日：2000-03-31

    申请人： Ezio Bombardelli ,  Cesare Ponzone

    发明人： Ezio Bombardelli ,  Cesare Ponzone

    IPC分类号： C12P1944

    CPC分类号： C12P19/56

    摘要： The present invention relates to the microbial biotransformation of colchiconic compounds into derivative compounds, which are glycosylated exclusively at the C-3 position of the six-member ring. The process of the present invention provides the 3-O-glycosyl derivatives in high yields and purity.

    摘要翻译： 本发明涉及可可丝素化合物微生物转化为衍生化合物，其仅在六元环的C-3位糖基化。 本发明的方法以高产率和纯度提供了3-O-糖基衍生物。

    Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity
    9.
    发明授权
    Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity 有权
    用于治疗糖尿病和肥胖症的α-葡糖苷酶抑制剂的α-淀粉酶抑制剂的制剂

    公开(公告)号：US07553502B2

    公开(公告)日：2009-06-30

    申请号：US12042355

    申请日：2008-03-05

    申请人： Ezio Bombardelli ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    发明人： Ezio Bombardelli ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    IPC分类号： A01N65/00

    CPC分类号： A61K36/37 ,  A61K36/48 ,  A61K2300/00

    摘要： This invention relates to the combination of α-amylase inhibitors prepared from Phaseolus vulgaris with α-glucosidase inhibitors obtained from Salacia oblonga and other species. The α-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with α-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.

    摘要翻译： 本发明涉及从菜豆提取物制备的α-淀粉酶抑制剂与从长颈鹿藻和其他物种获得的α-葡糖苷酶抑制剂的组合。 α-淀粉酶抑制剂伴随着一定量的凝集素，其降低源自饮食中存在的淀粉的葡萄糖的量，并且在重复给药后显着降低食欲。 与α-葡萄糖苷酶抑制剂（如Salacia提取物或其中存在的硫代糖）的组合进一步降低血糖，协同作用，从而减少碳水化合物的脂肪合成。