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    Metastatic colon cancer specific promoter and uses thereof
    4.
    发明申请
    Metastatic colon cancer specific promoter and uses thereof 审中-公开
    转移性结肠癌特异性启动子及其用途

    公开(公告)号：US20090156796A1

    公开(公告)日：2009-06-18

    申请号：US12011966

    申请日：2008-01-29

    申请人： Yuanhao Li ,  De-Chao Yu

    发明人： Yuanhao Li ,  De-Chao Yu

    IPC分类号： C07H21/04

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/008 ,  C12N2830/85

    摘要： Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.

    摘要翻译： 提供结肠癌特异性启动子序列和腺病毒载体。 通过提供依赖于仅在特定的有限细胞类型中有活性的转录因子的转录起始调节，病毒复制将限于靶细胞。 修饰的腺病毒可以用作引入新遗传能力的载体，特别是与用于治疗瘤形成的细胞毒性有关。

    Metastatic colon cancer specific promoter and uses thereof
    5.
    发明授权
    Metastatic colon cancer specific promoter and uses thereof 失效
    转移性结肠癌特异性启动子及其用途

    公开(公告)号：US07364727B2

    公开(公告)日：2008-04-29

    申请号：US10624670

    申请日：2003-07-21

    申请人： Yuanhao Li ,  De-Chao Yu

    发明人： Yuanhao Li ,  De-Chao Yu

    IPC分类号： A01N63/00 ,  C12N15/00 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/008 ,  C12N2830/85

    摘要： Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.

    摘要翻译： 提供结肠癌特异性启动子序列和腺病毒载体。 通过提供依赖于仅在特定的有限细胞类型中有活性的转录因子的转录起始调节，病毒复制将限于靶细胞。 修饰的腺病毒可以用作引入新遗传能力的载体，特别是与用于治疗瘤形成的细胞毒性有关。

    Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
    7.
    发明授权
    Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof 失效
    特异于表达雄激素受体的细胞的腺病毒载体及其使用方法

    公开(公告)号：US07319033B2

    公开(公告)日：2008-01-15

    申请号：US10222479

    申请日：2002-08-16

    申请人： Daniel R. Henderson ,  Eric R. Schuur ,  De-Chao Yu

    发明人： Daniel R. Henderson ,  Eric R. Schuur ,  De-Chao Yu

    IPC分类号： C12N15/861 ,  C12N15/63 ,  C12N15/64 ,  A61K48/00

    CPC分类号： A61K35/761 ,  A61K47/6901 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/008

    摘要： Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise an adenoviral gene under control of a transcriptional regulatory portion of a PB-TRE, which is in turn dependent upon AR expression. The gene can be, for example, a gene required for viral replication or the adenovirus death protein gene (ADP). The viruses can also comprise at least one additional adenoviral gene under control of at least one additional prostate-specific transcriptional response element, such as that controlling prostate-specific antigen expression (PSA-TRE). Thus, virus replication can be restricted to target cells exhibiting prostate-specific gene expression, particularly prostate carcinoma cells.

    摘要翻译： 提供了允许probasin转录应答元件（PB-TRE）起作用的细胞特异性的复制能力的腺病毒载体，例如表达雄激素受体（AR）的细胞，以及使用此类病毒的方法。 这些病毒包含由PB-TRE的转录调节部分控制的腺病毒基因，其又依赖于AR表达。 该基因可以是例如病毒复制所需的基因或腺病毒死亡蛋白基因（ADP）。 病毒还可以包含至少一种额外的腺病毒基因，其由至少一种另外的前列腺特异性转录应答元件（例如控制前列腺特异性抗原表达（PSA-TRE））控制。 因此，病毒复制可以限于表现出前列腺特异性基因表达的靶细胞，特别是前列腺癌细胞。

    Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
    8.
    发明授权
    Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof 失效
    特异于表达雄激素受体的细胞的腺病毒载体及其使用方法

    公开(公告)号：US06436394B1

    公开(公告)日：2002-08-20

    申请号：US09614495

    申请日：2000-07-11

    申请人： Daniel R. Henderson ,  Eric R. Schuur ,  De-Chao Yu

    发明人： Daniel R. Henderson ,  Eric R. Schuur ,  De-Chao Yu

    IPC分类号： A61K4800

    CPC分类号： A61K35/761 ,  A61K47/6901 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/008

    摘要： Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise and adenoviral gene under control of a transcription regulatory portion of a PB-TRE, which is in turn dependent upon AR expression. The gene can be, for example, a gene required for viral replication or the adenovirus death protein gene (ADP). The viruses can also comprise at least one additional adenoviral gene under control of at least one additional prostate-specific transcriptional response element, such as that controlling prostate-specific antigen expression (PSA-TRE). Thus, virus replication can be restricted to target cells exhibiting prostate-specific gene expression, particularly prostate carcinoma cells. An adenovirus of the present invention can further comprise a heterologus gene such as a reporter under transcriptional control of a PB-TRE. The adenovirus vectors can be used to detect and monitor samples for the presence of prostate cells as well as to selectively kill malignant cells producing prostate-specific gene products.

    摘要翻译： 提供了允许probasin转录应答元件（PB-TRE）起作用的细胞特异性的复制性腺病毒载体，例如表达雄激素受体（AR）的细胞，以及使用这些病毒的方法。 这些病毒包含由PB-TRE的转录调节部分控制的腺病毒基因，其又依赖于AR表达。 该基因可以是例如病毒复制所需的基因或腺病毒死亡蛋白基因（ADP）。 病毒还可以包含至少一种额外的腺病毒基因，其由至少一种额外的前列腺特异性转录应答元件（例如控制前列腺特异性抗原表达（PSA-TRE））控制。 因此，病毒复制可以限于表现出前列腺特异性基因表达的靶细胞，特别是前列腺癌细胞。 本发明的腺病毒还可以包含异源基因，例如在PB-TRE的转录控制下的报告物。 腺病毒载体可用于检测和监测样品中前列腺细胞的存在以及选择性杀死产生前列腺特异性基因产物的恶性细胞。