摘要:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要:
The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要:
The nested automatically separable flying disk assembly includes an outer or cover disk assembly enclosing a nested or inner disk assembly. The outer or cover disk assembly is of a generally cylinderical disk shape having an air space between itself and the nested or inner disk assembly provided by a central nub projection cooperating with flange nub projections. The nested or inner disk assembly is provided with an outer peripheral flange section extended downwardly and below a similar peripheral rim section on the outer or cover disk assembly for allowing air to flow therebetween to cause the desired separation between the nested disk assemblies. An adjustable central nub projection is provided to adjustably change separation between the outer or cover disk assembly and the nested or inner disk assembly. The nested or inner disk assembly is provided with a plurality of inclined concentric aerodynamic ridges to alter air flow and resultant turbulence of air flow between the nested disk assemblies to vary the aerodynamic flight characteristics thereof. Second and third embodiments provide different angular relationships, either inwardly or outwardly, of the outer adjacent peripheral rim section of the outer or cover disk assembly and the peripheral flange section of the nested or inner disk assembly to achieve an increase or decrease in the time of separation of the outer or cover disk assembly from the nested or inner disk assembly.
摘要:
Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., anxiety and depression, treatable by antagonizing CRF receptors.