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公开(公告)号：US20100160316A1
公开(公告)日：2010-06-24
申请号：US12714871
申请日：2010-03-01
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/5377 , C07D239/86 , A61K31/517 , C07D239/88 , C07D413/10 , A61K31/496 , A61P19/10 , A61P19/02 , A61P17/02 , A61P21/00 , A61P13/02 , A61P11/00 , C07D403/04
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US07713983B2
公开(公告)日：2010-05-11
申请号：US10935008
申请日：2004-09-02
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D239/94 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120040935A1
公开(公告)日：2012-02-16
申请号：US13110173
申请日：2011-05-18
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/675 , A61K31/517 , C12N5/071 , A61P29/00 , A61P25/04 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P25/28 , A61P1/00 , A61P21/00 , A61K31/5377
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07968545B2
公开(公告)日：2011-06-28
申请号：US10912912
申请日：2004-08-05
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D413/04 , C07D403/04 , C07D401/04 , A61K31/5355 , A61K31/517 , A61K31/497 , A61K31/519 , A61P21/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P9/10
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07678802B2
公开(公告)日：2010-03-16
申请号：US10792688
申请日：2004-03-03
申请人： Jesus E. Gonzalez, III , Dean Mitchell Wilson , Andreas Peter Termin , Peter Diederik Jan Grootenhuis , Yulian Zhang , Benjamin John Petzoldt , Lev Tyler Dewey Fanning , Timothy Donald Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean Mitchell Wilson , Andreas Peter Termin , Peter Diederik Jan Grootenhuis , Yulian Zhang , Benjamin John Petzoldt , Lev Tyler Dewey Fanning , Timothy Donald Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , A61K31/517 , C07D417/04 , C07D417/12 , C07D417/14 , C07D409/04 , C07D405/12 , C07D413/12 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20120238578A1
公开(公告)日：2012-09-20
申请号：US13478538
申请日：2012-05-23
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4245 , A61K31/517 , A61K31/53 , A61K31/498 , A61K31/4725 , A61P25/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P1/00 , C12N5/071 , A61K31/4709
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100087479A1
公开(公告)日：2010-04-08
申请号：US12556845
申请日：2009-09-10
IPC分类号： A61K31/4725 , C12N5/02 , A61K31/427 , A61K31/433 , A61K31/4709
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07615563B2
公开(公告)日：2009-11-10
申请号：US11060719
申请日：2005-02-17
IPC分类号： C07D277/46 , C07D417/12 , A61K31/426 , A61K31/4709 , A61K31/4725
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07705031B2
公开(公告)日：2010-04-27
申请号：US11933724
申请日：2007-11-01
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
IPC分类号： A61K31/4184 , A61K31/165
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中式I的R 1，Z，Y，RA和W基团如本文所定义。 本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20080306129A1
公开(公告)日：2008-12-11
申请号：US11933724
申请日：2007-11-01
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T.D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T.D. Fanning
IPC分类号： A61K31/4184 , A61P29/00
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中式I的R 1，Z，Y，RA和W基团如本文所定义。 本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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