公开(公告)号：US20060140933A1

公开(公告)日：2006-06-29

申请号：US10643589

申请日：2003-08-18

申请人： Debra Pittman ,  Brian Clancy ,  Glenn Larsen ,  William Trepicchio ,  Fionula Brennan ,  Marc Feldmann ,  Brian John Foxwell ,  Jeffrey Feldman

发明人： Debra Pittman ,  Brian Clancy ,  Glenn Larsen ,  William Trepicchio ,  Fionula Brennan ,  Marc Feldmann ,  Brian John Foxwell ,  Jeffrey Feldman

IPC分类号： A61K39/395 ,  C07K16/46

CPC分类号： C07K14/70503 ,  C07K2319/30 ,  C07K2319/70

摘要： Fusion proteins comprising a Receptor for Advanced Glycation End Products Ligand Binding Element (RAGE-LBE) and an immunoglobulin element are disclosed. Also disclosed are fusion proteins comprising a RAGE-LBE and a dimerization domain. Also disclosed are nucleic acids encoding such fusion proteins and methods for using disclosed nucleic acids and proteins to, for example, treat RAGE-related disorders. Additional compositions and methods are also disclosed.

摘要翻译： 公开了包含高级糖基末端产物配体结合元件（RAGE-LBE）的受体和免疫球蛋白元件的融合蛋白。 还公开了包含RAGE-LBE和二聚化结构域的融合蛋白。 还公开了编码这种融合蛋白的核酸和使用公开的核酸和蛋白质例如治疗RAGE相关病症的方法。 还公开了另外的组合物和方法。

公开(公告)号：US20070286858A1

公开(公告)日：2007-12-13

申请号：US11689480

申请日：2007-03-21

申请人： Brian Clancy ,  Debra Pittman ,  Xiang-Yang Tan ,  Lioudmila Tchistiakova ,  Kodangattil Sreekumar ,  Janet Paulsen ,  Angela Widom ,  Nicole Piche-Nicholas ,  Ying Sun

发明人： Brian Clancy ,  Debra Pittman ,  Xiang-Yang Tan ,  Lioudmila Tchistiakova ,  Kodangattil Sreekumar ,  Janet Paulsen ,  Angela Widom ,  Nicole Piche-Nicholas ,  Ying Sun

IPC分类号： A61K39/395 ,  A61P19/02 ,  A61P7/12 ,  C07H21/04 ,  C07K16/28

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/70503 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： Antibodies that bind specifically to receptor for advanced glycation end products (RAGE) and RAGE-binding fragments thereof are disclosed. Also disclosed are pharmaceutical compositions comprising such anti-RAGE antibodies and RAGE-binding antibody fragments thereof, and their use for treatment of RAGE related diseases.

摘要翻译： 公开了特异性结合用于晚期糖基化终产物（RAGE）和RAGE结合片段的受体的抗体。 还公开了包含这种抗RAGE抗体和其RAGE结合抗体片段的药物组合物及其用于治疗RAGE相关疾病的用途。

公开(公告)号：US20060099186A1

公开(公告)日：2006-05-11

申请号：US11315277

申请日：2005-12-23

申请人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

发明人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

IPC分类号： A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/51 ,  C12N2710/10343 ,  C12N2800/108

摘要： Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses compositions and methods for systemic administration of bone morphogenetic proteins for promotion of osteogenesis. These compositions and methods may be used in bone fracture healing and repair. These composition of the invention may be further utilized in increasing bone mineral density.

公开(公告)号：US07226587B2

公开(公告)日：2007-06-05

申请号：US10157839

申请日：2002-05-31

申请人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

发明人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

IPC分类号： A61K48/00 ,  A01N63/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/51 ,  C12N2710/10343 ,  C12N2800/108

摘要： Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses compositions and methods for systemic administration of bone morphogenetic proteins for promotion of osteogenesis. These compositions and methods may be used in bone fracture healing and repair. These composition of the invention may be further utilized in increasing bone mineral density.

摘要翻译： 公开了用于全身施用编码用于促进成骨的骨形态发生蛋白的DNA的组合物和方法。 本发明的组合物和方法可用于骨折修复。 本发明还公开了用于全身施用骨形态发生蛋白以促进成骨的组合物和方法。 这些组合物和方法可用于骨折愈合和修复。 本发明的这些组合物可以进一步用于增加骨矿物质密度。