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    Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
    4.
    发明授权
    Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins 失效
    用于全身施用编码骨形态发生蛋白的序列的组合物和方法

    公开(公告)号：US07226587B2

    公开(公告)日：2007-06-05

    申请号：US10157839

    申请日：2002-05-31

    申请人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

    发明人： Brian Clancy ,  Debra Pittman ,  Howard Seeherman

    IPC分类号： A61K48/00 ,  A01N63/00

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/51 ,  C12N2710/10343 ,  C12N2800/108

    摘要： Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be utilized for fracture repair. The invention further discloses compositions and methods for systemic administration of bone morphogenetic proteins for promotion of osteogenesis. These compositions and methods may be used in bone fracture healing and repair. These composition of the invention may be further utilized in increasing bone mineral density.

    摘要翻译： 公开了用于全身施用编码用于促进成骨的骨形态发生蛋白的DNA的组合物和方法。 本发明的组合物和方法可用于骨折修复。 本发明还公开了用于全身施用骨形态发生蛋白以促进成骨的组合物和方法。 这些组合物和方法可用于骨折愈合和修复。 本发明的这些组合物可以进一步用于增加骨矿物质密度。

    Expression of the cysteine protease legumain in vascular and inflammatory diseases
    6.
    发明申请
    Expression of the cysteine protease legumain in vascular and inflammatory diseases 审中-公开
    半胱氨酸蛋白酶在血管和炎症疾病中的表达

    公开(公告)号：US20070274987A1

    公开(公告)日：2007-11-29

    申请号：US11806000

    申请日：2007-05-25

    申请人： Valerie Clerin ,  Heather Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave Hebert ,  Debra Pittman ,  Nanhua Deng

    发明人： Valerie Clerin ,  Heather Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave Hebert ,  Debra Pittman ,  Nanhua Deng

    IPC分类号： A61K39/395 ,  A61K38/17 ,  C07H21/04 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C12N9/6472 ,  A61K38/00 ,  C12Y304/22034 ,  G01N33/5091 ,  G01N2333/95 ,  G01N2800/32

    摘要： The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.

    摘要翻译： 本发明提供了与哺乳动物（例如，小鼠和人）legumain和新型legumain拼接变体ZB-1相关的分离和纯化的多核苷酸，多肽和抗体。 本发明还涉及这些分离和纯化的多核苷酸，多肽和抗体以及其他legumain和ZB-1激动剂和拮抗剂在调节legumain和/或ZB-1活性，表达和/或分泌中的用途 细胞或细胞群，例如单核细胞，巨噬细胞，泡沫细胞，血管内皮细胞，肾近端小管细胞，动脉内皮细胞，炎性细胞侵入血管内膜的部位和动脉的新内膜损伤区域。 本发明还提供legumain和ZB-1拮抗剂，例如对于legumain和ZB-1，legumain和ZB-1抑制性多肽的拮抗性小分子，抗体和抗体片段，以及legumain和ZB-1抑制性多核苷酸。 本发明还涉及用于诊断，预后，监测，治疗，改善和/或预防血管疾病/疾病和炎症性疾病/疾病的新颖方法。