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公开(公告)号：US20060140933A1
公开(公告)日：2006-06-29
申请号：US10643589
申请日：2003-08-18
申请人： Debra Pittman , Brian Clancy , Glenn Larsen , William Trepicchio , Fionula Brennan , Marc Feldmann , Brian John Foxwell , Jeffrey Feldman
发明人： Debra Pittman , Brian Clancy , Glenn Larsen , William Trepicchio , Fionula Brennan , Marc Feldmann , Brian John Foxwell , Jeffrey Feldman
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K14/70503 , C07K2319/30 , C07K2319/70
摘要： Fusion proteins comprising a Receptor for Advanced Glycation End Products Ligand Binding Element (RAGE-LBE) and an immunoglobulin element are disclosed. Also disclosed are fusion proteins comprising a RAGE-LBE and a dimerization domain. Also disclosed are nucleic acids encoding such fusion proteins and methods for using disclosed nucleic acids and proteins to, for example, treat RAGE-related disorders. Additional compositions and methods are also disclosed.
摘要翻译： 公开了包含高级糖基末端产物配体结合元件（RAGE-LBE）的受体和免疫球蛋白元件的融合蛋白。 还公开了包含RAGE-LBE和二聚化结构域的融合蛋白。 还公开了编码这种融合蛋白的核酸和使用公开的核酸和蛋白质例如治疗RAGE相关病症的方法。 还公开了另外的组合物和方法。
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公开(公告)号：US20050244849A1
公开(公告)日：2005-11-03
申请号：US11014625
申请日：2004-12-16
CPC分类号： C07K14/4713 , A61K38/00
摘要： The invention provides methods for identifying, designing, and optimizing therapeutics for R.A using as targets one or more genes (and/or their encoded gene products) that have been shown to be up- or down-regulated in cells of R.A. relative to normal counterpart cells. Methods and compositions for diagnostic assays for detecting R.A. are also provided.
摘要翻译： 本发明提供了用于鉴定，设计和优化用于作为靶标的治疗的治疗方法，所述基因一个或多个基因（和/或其编码的基因产物）已被证明在R.A.的细胞中被上调或下调。 相对于正常的对应细胞。 用于检测R.A.的诊断测定法的方法和组合物 也提供。
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公开(公告)号：US20050202451A1
公开(公告)日：2005-09-15
申请号：US10834114
申请日：2004-04-29
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , G01N33/6896
摘要： Methods, systems and equipment for diagnosing or monitoring the progression or treatment of AML or MDS. This invention identifies a plurality of AML or MDS disease genes which are differentially expressed in bone marrow cells of AML or MDS patients as compared to disease-free humans. These AML or MDS disease genes can be used as molecular markers for detecting the presence or absence of AML or MDS. These genes can also be used for the early identification of MDS patients who eventually progress to AML.
摘要翻译： 用于诊断或监测AML或MDS进展或治疗的方法，系统和设备。 本发明鉴定了与无疾病人相比，在AML或MDS患者的骨髓细胞中差异表达的多种AML或MDS疾病基因。 这些AML或MDS疾病基因可用作检测AML或MDS存在或不存在的分子标志物。 这些基因也可用于早期鉴定最终进展为AML的MDS患者。
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公开(公告)号：US20070198198A1
公开(公告)日：2007-08-23
申请号：US11789104
申请日：2007-04-23
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , G01N33/6896
摘要： Methods, systems and equipment for diagnosing or monitoring the progression or treatment of AML or MDS. This invention identifies a plurality of AML or MDS disease genes which are differentially expressed in bone marrow cells of AML or MDS patients as compared to disease-free humans. These AML or MDS disease genes can be used as molecular markers for detecting the presence or absence of AML or MDS. These genes can also be used for the early identification of MDS patients who eventually progress to AML.
摘要翻译： 用于诊断或监测AML或MDS进展或治疗的方法，系统和设备。 本发明鉴定了与无疾病人相比，在AML或MDS患者的骨髓细胞中差异表达的多种AML或MDS疾病基因。 这些AML或MDS疾病基因可用作检测AML或MDS存在或不存在的分子标记。 这些基因也可用于早期鉴定最终进展为AML的MDS患者。
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公开(公告)号：US20050287532A9
公开(公告)日：2005-12-29
申请号：US10775169
申请日：2004-02-11
IPC分类号： A61K38/17 , C07K16/18 , C12N20060101 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Methods, systems and equipment useful for monitoring in vivo activities of CCI-779 or other drugs. Numerous drug activity genes can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells can be modulated by CCI-779 or other drugs. Therefore, these genes can be used as surrogate markers for monitoring drug activities in vivo.
摘要翻译： 可用于监测CCI-779或其他药物体内活动的方法，系统和设备。 可以通过本发明鉴定许多药物活性基因。 这些基因在外周血单个核细胞中的表达谱可以通过CCI-779或其他药物调节。 因此，这些基因可以用作体内监测药物活性的替代标记物。
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公开(公告)号：US20080032299A1
公开(公告)日：2008-02-07
申请号：US11715606
申请日：2007-03-08
申请人： Michael Burczynski , Natalie Twine , William Trepicchio , Andrew Strahs , Fred Immermann , Donna Slonim , Andrew Dorner
发明人： Michael Burczynski , Natalie Twine , William Trepicchio , Andrew Strahs , Fred Immermann , Donna Slonim , Andrew Dorner
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57438 , G01N33/57496 , G16B25/00
摘要： Solid tumor prognosis genes, and methods, systems and equipment of using these genes for the prognosis and treatment of solid tumors. Prognosis genes for a solid tumor can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells (PBMCs) are correlated with clinical outcome of the solid tumor. The prognosis genes of the present invention can be used as surrogate markers for predicting clinical outcome of a solid tumor in a patient of interest. These genes can also be used to select a treatment which has a favorable prognosis for the solid tumor of the patient of interest.
摘要翻译： 实体肿瘤预后基因，以及使用这些基因进行实体瘤预后和治疗的方法，系统和设备。 通过本发明可以鉴定实体瘤的预后基因。 这些基因在外周血单个核细胞（PBMCs）中的表达谱与实体瘤的临床结果相关。 本发明的预后基因可用作用于预测感兴趣患者中实体瘤的临床结果的替代标记。 这些基因也可用于选择对感兴趣的患者的实体瘤具有良好预后的治疗。
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公开(公告)号：US20060134671A1
公开(公告)日：2006-06-22
申请号：US11285502
申请日：2005-11-22
申请人： Michael Burczynski , Andrew Dorner , Natalie Twine , William Trepicchio , Donna Slonim , Andrew Strahs , Frederick Immermann
发明人： Michael Burczynski , Andrew Dorner , Natalie Twine , William Trepicchio , Donna Slonim , Andrew Strahs , Frederick Immermann
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides methods, systems and equipment for the prognosis and treatment of renal cell carcinoma (RCC) or other solid tumors. Genes prognostic of clinical outcomes of a solid tumor can be identified according to the present invention. The expression profiles of these genes in peripheral blood mononuclear cells (PBMCs) of patients who have the solid tumor are correlated with clinical outcome of these patients. Examples of RCC prognosis genes are illustrated in Tables 2 and 3. These genes can be used as surrogate markers for predicting clinical outcome of an RCC patient of interest. These genes can also be used for the selection of a favorable treatment for an RCC patient of interest.
摘要翻译： 本发明提供了用于预后和治疗肾细胞癌（RCC）或其他实体瘤的方法，系统和设备。 可以根据本发明鉴定实体瘤的临床结果的基因预后。 这些基因在具有实体瘤的患者的外周血单核细胞（PBMC）中的表达谱与这些患者的临床结果相关。 RCC预后基因的实例如表2和3所示。这些基因可用作预测感兴趣的RCC患者的临床结果的替代标志物。 这些基因也可用于选择感兴趣的RCC患者的有利治疗。
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公开(公告)号：US20060194211A1
公开(公告)日：2006-08-31
申请号：US10834268
申请日：2004-04-29
申请人： Michael Burczynski , Natalie Twine , William Trepicchio , Andrew Strahs , Fred Immermann , Donna Slonim , Andrew Dorner
发明人： Michael Burczynski , Natalie Twine , William Trepicchio , Andrew Strahs , Fred Immermann , Donna Slonim , Andrew Dorner
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57438 , G01N33/57496 , G16B25/00
摘要： Solid tumor prognosis genes, and methods, systems and equipment of using these genes for the prognosis and treatment of solid tumors. Prognosis genes for a solid tumor can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells (PBMCs) are correlated with clinical outcome of the solid tumor. The prognosis genes of the present invention can be used as surrogate markers for predicting clinical outcome of a solid tumor in a patient of interest. These genes can also be used to select a treatment which has a favorable prognosis for the solid tumor of the patient of interest.
摘要翻译： 实体肿瘤预后基因，以及使用这些基因进行实体瘤预后和治疗的方法，系统和设备。 通过本发明可以鉴定实体瘤的预后基因。 这些基因在外周血单个核细胞（PBMCs）中的表达谱与实体瘤的临床结果相关。 本发明的预后基因可用作用于预测感兴趣患者中实体瘤的临床结果的替代标记。 这些基因也可用于选择对感兴趣的患者的实体瘤具有良好预后的治疗。
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