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    Patterning and alteration of molecules
    2.
    发明申请
    Patterning and alteration of molecules 有权
    分子的形成和改变

    公开(公告)号：US20070000866A1

    公开(公告)日：2007-01-04

    申请号：US11401485

    申请日：2006-04-10

    申请人： Declan Ryan ,  Babak Amir-Parviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel Sia ,  George Whitesides

    发明人： Declan Ryan ,  Babak Amir-Parviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel Sia ,  George Whitesides

    IPC分类号： C23F1/00 ,  H01L21/302 ,  B44C1/22

    CPC分类号： G03F7/165 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B82Y5/00 ,  B82Y30/00 ,  C03C17/28 ,  C03C23/0005 ,  C03C2218/32 ,  C40B80/00 ,  G03F7/203

    摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.

    摘要翻译： 本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。 在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。 通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。 在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。 在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。 在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。 在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。 在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。 在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。 在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

    Patterning and alteration of molecules
    3.
    发明申请
    Patterning and alteration of molecules 审中-公开
    分子的形成和改变

    公开(公告)号：US20060138083A1

    公开(公告)日：2006-06-29

    申请号：US11222500

    申请日：2005-09-08

    申请人： Declan Ryan ,  Babak Amirparviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel Sia ,  Jing Su ,  Milan Mrksich ,  George Whitesides

    发明人： Declan Ryan ,  Babak Amirparviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel Sia ,  Jing Su ,  Milan Mrksich ,  George Whitesides

    IPC分类号： C23F1/00 ,  B44C1/22 ,  C03C25/68 ,  G03F1/00

    CPC分类号： G03F7/165 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B82Y5/00 ,  B82Y30/00 ,  C03C17/28 ,  C03C23/0005 ,  C03C2218/32 ,  C40B80/00 ,  G03F7/203

    摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.

    摘要翻译： 本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。 在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。 通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。 在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。 在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。 在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。 在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。 在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。 在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。 在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

    UREA OLIGOMERS, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    6.
    发明申请
    UREA OLIGOMERS, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
    尿素低聚物，其制备方法和含有它们的药物组合物

    公开(公告)号：US20100184849A1

    公开(公告)日：2010-07-22

    申请号：US12716602

    申请日：2010-03-03

    申请人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

    发明人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

    IPC分类号： A61K31/352 ,  A61K31/17 ,  A61P35/00

    CPC分类号： C07C279/12 ,  C07C275/24 ,  C07C323/60 ,  C07D311/82

    摘要： A method for treating a cytotoxic disease by administrating compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra.

    摘要翻译： 通过施用具有通式X-（A）n-Y的化合物来治疗细胞毒性疾病的方法，其中：n在6和20之间变化; X表示氢原子，RaCO，RaOCO，RaNHCO或RaSO2基团，Ra是烷基，烯基，炔基，芳基，芳烷基，杂芳基，该基团被取代或未被取代，条件是当n为 等于6; A表示具有式（I）或（II）的基团，其中R 1是氢原子，氨基酸侧链，烷基，烯基，炔基，芳基，芳烷基或杂芳基，所述基团被取代， 是1和n之间的整数; Y是具有与先前对Ra相同的含义的NRbRc，Rb和Rc基团。

    METHOD FOR TREATING SURFACES CONTAINING SI-H GROUPS
    7.
    发明申请
    METHOD FOR TREATING SURFACES CONTAINING SI-H GROUPS 审中-公开
    用于处理包含SI-H组的表面的方法

    公开(公告)号：US20090280337A1

    公开(公告)日：2009-11-12

    申请号：US12441936

    申请日：2007-10-03

    申请人： Vincent Semetey ,  Nasreddine Kebir

    发明人： Vincent Semetey ,  Nasreddine Kebir

    IPC分类号： B05D3/00 ,  B32B27/28

    CPC分类号： C08J7/047 ,  C08J7/12 ,  Y10T428/31663

    摘要： The present invention relates to method for treating a substrate or a surface thereof bearing Si—H groups to confer to it a physical and/or biochemical surface-modified property, wherein it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a polymer, said polymer containing: at least three reactive sites able to attach to said substrate or said surface by reacting with Si—H groups and further creating covalent bonds, and at least a molecule or a part thereof able to confer said modified property to said substrate or said surface thereof, said step being carried out in efficient conditions to promote the covalent grafting of said polymer to said substrate or surface thereof and the molecular weight of said polymer being greater than 1000 g/mol.

    摘要翻译： 本发明涉及用于处理含有Si-H基团的基底或其表面以赋予其物理和/或生物化学表面改性性质的方法，其中它包括至少一个步骤，该步骤包括在液体介质， 所述基质或其表面与至少一种聚合物形成，所述聚合物含有：至少三个能够通过与Si-H基团反应并进一步产生共价键而与所述基底或所述表面附着的反应位点，以及至少一个分子或 其部分能够将所述改性的性质赋予所述基材或其表面，所述步骤在有效条件下进行，以促进所述聚合物共价接枝到所述基材或其表面，并且所述聚合物的分子量大于1000g / mol。

    Pseudopeptide, synthesis method, reagent and applications
    8.
    发明授权
    Pseudopeptide, synthesis method, reagent and applications 失效
    伪肽，合成方法，试剂和应用

    公开(公告)号：US07199215B1

    公开(公告)日：2007-04-03

    申请号：US09889178

    申请日：2000-01-12

    申请人： Jean-Paul Briand ,  Vincent Semetey ,  David Limal

    发明人： Jean-Paul Briand ,  Vincent Semetey ,  David Limal

    IPC分类号： A61K38/00

    CPC分类号： C07K7/02 ,  A61K38/00

    摘要： The invention concerns a pseudopeptide of at least 6 amino acids comprising at least a unit selected among the general formulae (I) and/or (II) wherein: R1, R2 and R3 each independently of one another represent a side-chain of amino acids and can be identical or different; X represents an oxygen or sulphur atom. The invention also concerns its synthesis process, a reagent containing it, a detection kit comprising such a reagent, a method for detecting an antigen or an antibody using said pseudopeptide, and antibody or and anti-idiotype and finally a therapeutic composition.

    摘要翻译： 本发明涉及包含至少一个选自通式（I）和/或（II）中的单元的至少6个氨基酸的假肽，其中：R 1，R 2， 和R 3各自彼此独立地表示氨基酸的侧链，并且可以相同或不同; X表示氧或硫原子。 本发明还涉及其合成方法，含有它的试剂，包含这种试剂的检测试剂，使用所述假肽检测抗原或抗体的方法，以及抗体或抗独特型，最后是治疗组合物。

    Urea oligomers, their preparation process and pharmaceutical compositions containing them
    9.
    发明授权
    Urea oligomers, their preparation process and pharmaceutical compositions containing them 有权
    尿素低聚物，其制备方法和含有它们的药物组合物

    公开(公告)号：US08071640B2

    公开(公告)日：2011-12-06

    申请号：US12716602

    申请日：2010-03-03

    申请人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

    发明人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

    IPC分类号： A01N43/16 ,  A01N47/10 ,  A01N37/18

    CPC分类号： C07C279/12 ,  C07C275/24 ,  C07C323/60 ,  C07D311/82

    摘要： A method for treating a cytotoxic disease by administrating compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra.

    摘要翻译： 通过施用具有通式X-（A）n-Y的化合物来治疗细胞毒性疾病的方法，其中：n在6和20之间变化; X表示氢原子，RaCO，RaOCO，RaNHCO或RaSO2基团，Ra是烷基，烯基，炔基，芳基，芳烷基，杂芳基，该基团被取代或未被取代，条件是当n为 等于6; A表示具有式（I）或（II）的基团，其中R 1是氢原子，氨基酸侧链，烷基，烯基，炔基，芳基，芳烷基或杂芳基，所述基团被取代， 是1和n之间的整数; Y是具有与先前对Ra相同的含义的NRbRc，Rb和Rc基团。

    Method for Treating Surfaces with Copolymers
    10.
    发明申请
    Method for Treating Surfaces with Copolymers 失效
    用共聚物处理表面的方法

    公开(公告)号：US20080226585A1

    公开(公告)日：2008-09-18

    申请号：US11885283

    申请日：2006-03-29

    申请人： Othman Bouloussa ,  Vincent Semetey ,  Francis Rondelez

    发明人： Othman Bouloussa ,  Vincent Semetey ,  Francis Rondelez

    IPC分类号： A61K31/79 ,  A61P31/00

    CPC分类号： A61L2/16 ,  A61L2/232

    摘要： The present invention relates to a method for treating at least a surface of a substrate containing labile hydrogen atoms to confer to it cytotoxic properties or cell-adhesion properties, characterized in that it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a copolymer, said copolymer containing at least a monomer unit of type A including at least a reactive site able to attach to said substrate or said surface by covalent bonds and at least a monomer unit of type B including at least one molecule able to confer antimicrobial, antiviricidal and/or antifungicidal or cell-adhesion properties to said substrate or said surface, said step being carried out in efficient conditions to promote the covalent grafting of said copolymer to said substrate or a surface thereof.

    摘要翻译： 本发明涉及一种用于处理至少含有不稳定氢原子的底物的表面以赋予其细胞毒性或细胞粘附性质的方法，其特征在于其至少包括在液体介质内暴露的步骤， 所述基材或其表面至少含有共聚物，所述共聚物至少包含A型单体单元，其至少包含能够通过共价键附着到所述基材或所述表面的反应性位点和至少一种B型单体单元 包括至少一种能够赋予所述基底或所述表面的抗微生物，抗杀病毒和/或抗真菌或细胞粘附性能的分子，所述步骤在有效条件下进行以促进所述共聚物共价接枝到所述基底或其表面 。