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公开(公告)号：US08158437B2
公开(公告)日：2012-04-17
申请号：US12308298
申请日：2007-08-02
CPC分类号： G01N33/0057 , G01N2021/6432 , Y10T436/17 , Y10T436/173076 , Y10T436/173845 , Y10T436/174614 , Y10T436/175383
摘要： The present invention generally relates to methods for modulating the optical properties of a luminescent polymer via interaction with a species (e.g., an analyte). In some cases, the present invention provides methods for determination of an analyte by monitoring a change in an optical signal of a luminescent polymer upon exposure to an analyte. Methods of the present invention may be useful for the vapor phase detection of analytes such as explosives and toxins. The present invention also provides methods for increasing the luminescence intensity of a polymer, such as a polymer that has been photobleached, by exposing the luminescent polymer to a species such as a reducing agent.
摘要翻译： 本发明一般涉及通过与物质（例如分析物）的相互作用来调节发光聚合物的光学性质的方法。 在一些情况下，本发明提供了通过在暴露于分析物时监测发光聚合物的光学信号的变化来测定分析物的方法。 本发明的方法可用于分析物如爆炸物和毒素的气相检测。 本发明还提供了通过将发光聚合物暴露于诸如还原剂的物质来提高聚合物（例如已经漂白的聚合物）的发光强度的方法。
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2.发明授权公开(公告)号：US08124743B2
公开(公告)日：2012-02-28
申请号：US12303089
申请日：2007-06-01
申请人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
发明人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
CPC分类号： C07K16/065 , C07K16/468 , C07K2317/31 , C07K2317/54 , Y10S436/822
摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.
摘要翻译： 本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到 可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。
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公开(公告)号：US20100022011A1
公开(公告)日：2010-01-28
申请号：US11581777
申请日：2006-10-16
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其它化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US07862775B2
公开(公告)日：2011-01-04
申请号：US12693868
申请日：2010-01-26
IPC分类号： G01N21/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US20100303672A1
公开(公告)日：2010-12-02
申请号：US12693868
申请日：2010-01-26
IPC分类号： G01N21/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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公开(公告)号：US07666684B2
公开(公告)日：2010-02-23
申请号：US11581777
申请日：2006-10-16
IPC分类号： G01N33/00
CPC分类号： G01N21/643 , G01N33/22 , G01N2021/6432 , G01N2021/6441 , G01N2021/7786 , Y10T436/145555 , Y10T436/17 , Y10T436/200833
摘要： The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.
摘要翻译： 本发明提供用于测定分析物的传感器和方法。 分析物可以通过监测例如在暴露于分析物时发射材料的光学信号的变化来确定。 在一些实施方案中，分析物和发射材料可通过化学反应或其他化学，生物化学或生物相互作用（例如识别）相互作用以形成新的发射物质。 在某些情况下，本发明可用于检测分析物如爆炸物（例如RDX，PETN）。 本发明的方法的优点在于，发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。
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7.发明申请Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same 有权基于图案化多孔介质的横向流动和流通生物测定装置，制备方法及其使用方法公开(公告)号：US20090298191A1
公开(公告)日：2009-12-03
申请号：US12425121
申请日：2009-04-16
申请人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
发明人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译： 本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。 在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。
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公开(公告)号：US20090215189A1
公开(公告)日：2009-08-27
申请号：US11588881
申请日：2006-10-27
CPC分类号： G01N21/76 , C07F15/0086 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1092 , C09K2211/185 , G01N21/64 , G01N33/0057 , G01N33/20 , G01N2201/06113 , Y10T436/172307 , Y10T436/196666
摘要： The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices.
摘要翻译： 本发明一般涉及发射材料，器件和相关方法。 在一些情况下，本发明提供用于测定分析物的传感器和方法，其中分析物可以通过例如在暴露于分析物时监测发光材料的光学信号的变化来确定。 分析物和发射材料可通过诸如氧化加成反应或其他化学，生物化学或生物相互作用（例如识别）的化学反应相互作用以形成新的发射物质。 在一些情况下，本发明可用于检测各种分析物，例如毒素，化学战剂和爆炸物。 本发明还提供发射化合物和相关方法，包括能够与分析物相互作用以产生化合物的发射变化的金属络合物。 本发明的一些优点包括具有高特异性和灵敏度的分析物的测定以及制造简化和高度便携式装置的能力。
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公开(公告)号：US20130287961A1
公开(公告)日：2013-10-31
申请号：US13702376
申请日：2011-06-07
IPC分类号： B05D7/00
摘要： A method for modifying surface charges created by contact electrification includes providing a polymer formed of a plurality of monomers each containing a functional group capable of reversibly switching between a first structure and a second structure different from the first structure, the functional group having the first structure; contact-charging the polymer with a surface such that the polymer carries a first net surface charge; and converting the first structure of the functional group to the second structure. The sequence of the contact-charging and converting steps can be switched.
摘要翻译： 一种用于改变由接触带电产生的表面电荷的方法包括提供由多个单体形成的聚合物，每个单体各自含有能够在第一结构和不同于第一结构的第二结构之间可逆地切换的官能团，所述官能团具有第一结构 ; 使聚合物与表面接触，使得聚合物承载第一净表面电荷; 并将所述官能团的第一结构转化为第二结构。 可以切换接触充电和转换步骤的顺序。
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公开(公告)号：US08377710B2
公开(公告)日：2013-02-19
申请号：US12425121
申请日：2009-04-16
申请人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
发明人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
IPC分类号： G01N21/77
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
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